Skip to main content

Therapie des Postinfarktpatienten mit Antikoagulanzien und Thrombozytenfunktionshemmern

  • Conference paper
Medikamentöse Behandlung des Postinfarktpatienten nach CAST
  • 17 Accesses

Zusammenfassung

Es wird nun allgemein akzeptiert, daß die pathophysiologische Basis des akuten Myokardinfarktes die Ruptur eines atheromatösen Koronararterienplaques mit lokaler Thrombusbildung und konsekutivem Koronararterienversehluß ist (Abb. 1). Ausgehend von dem gegenwärtigen Verständnis, welches von einer in Richtung eines prothrombogenen Zustandes verschobenen, gestörten Interaktion von Gefäßwand, Blutplättchen und plasmatischen Hämostasekomponenten ausgeht, stehen gegenwärtig zur antithrombotischen Therapie des Postinfarktpatienten neben der Fibrinolysetherapie die Möglichkeiten der plasmatischen Antikoagulation sowie die pharmakologische Hemmung der Thrombozytenfunktion zur Verfügung.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Acheson J, Archibald D, Barnett H, Blakely J, Bousser M-G, Boysen G, Breddin K, M Britton, Cairns J, Canner P, Candelise L, Collins R (secretariat), Cortellaro M, Elwin C-E, Elwood P, Eschwege E, Farrel B (secretariat), Fields W, Gent M, Gray R (secretariat), Guiraud-Chaumeil B, Hardy R, Harker L, Helmers C, Hennekens C, Hutchinson EC, Klimt C, Lemak D, Loria Y, Lowenthal A, MacMahon S, Miller J (secretariat), Olsson J-E, Peto R (secretariat), Qizilbash N (secretariat), Rascol A, Reuther R, Richards S (secretariat), Robertson J, Rosen A, Sandercock P (secretariat), Sherry S, Soelberg-Sorensen P, Sweetnam P, Taylor W, Thibult N, van Gijn J, Vogel G, Wallentin L C, Warlow C (secretariat), Yusuf S (1988) Secondary prevention of vascular disease by prolonged antiplatelet treatment: antiplatelet trialists’ collaboration. Br Med J 296: 320–331

    Article  Google Scholar 

  2. An international Anticoagulant Review Group (1970) Collaborative analysis of long-termin anticoagulant administration after acute myocardial infarction. Lancet 2: 203–209

    Google Scholar 

  3. Berglund U, Wallentin L (1991) Persistent inhibition of platelet function during long-term treatment with 75 mg acetylsalicylic acid daily in men with unstable coronary artery disease. Eur Heart J, in press

    Google Scholar 

  4. Chesebro JH, Fuster V (1986) Antithrombotic therapy for acute myocardial infarction: mechanisms and prevention of deep venous, left ventricular and coronary artery thromboembolism. Circulation 74 (Suppl III): 1–10

    Article  Google Scholar 

  5. Cairns J, Gent M, Singer J, Finnie KJ, Forgatt GM, Holder D, Jablonsky G, Kostak JW, Melendez L, Myers M, Sackett D, Sealey B, Tanser PH (1985) A study of aspirin and/or sulfinpyrazone in unstable angina. N Engl J Med 313: 1369–1375

    Article  PubMed  CAS  Google Scholar 

  6. Ebert RV, Borden CV, Hipp HR, Holzmann D, Lyon AF, Schnaper H (1969) Long-term anticoagulant therapy after myocardial infarction: final report of the Veterans Administration Cooperative Study. JAMA 207: 2263–2267

    Article  PubMed  CAS  Google Scholar 

  7. Emerson PA, Marks P (1977) Preventing thromboembolism after myocardial infarction: effect of low-dose heparin or smoking. Br Med J 1: 18–22

    Article  PubMed  CAS  Google Scholar 

  8. E.P.S.I.M. Research Group (1982) A controlled comparison of aspirin and oral anticoagulants in prevention of deaths after myocardial infarction. N Engl J Med 302: 701–708

    Google Scholar 

  9. Fuster V, Stein B, Badimon L, Chesebro JH (1988) Antithrombotic therapy after myocardial reperfusion in acute myocardial infarction. J Am Coll Cardiol 12: 78A–84A

    Article  PubMed  CAS  Google Scholar 

  10. Fuster V, Halperin JL (1989) Left ventricular thrombi and cerebral embolism. N Engl J Med 320: 392–393

    Article  PubMed  CAS  Google Scholar 

  11. Gallus AS, Hirsh J, Tuttle RJ, Trebilcock R, O’Brien SE, Carroll JJ, Minden JH, Hudecki SM (1973) Small subcutaneous doses of heparin in prevention of venous thrombosis. N Engl J Med 288: 545–549

    Article  PubMed  CAS  Google Scholar 

  12. Hass WK, Easton JD, Admas HP, Pryse-Philips W, Molony BA, Anderson S (1989) A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. N Engl J med 321: 501–507

    Article  PubMed  CAS  Google Scholar 

  13. Hennekens CH, Buring JE, Sandercrock P, Collins R, Peto R (1989) Aspirin and other antiplatelet agents in the secondary and primary prevention of cardiovascular disease. Circulation 80: 749–756

    Article  PubMed  CAS  Google Scholar 

  14. ISIS-2 Collaborative Group (1988) Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17, 189 cases of suspected acute myocardial infarction: ISIS-2. Lancet 2: 34–39

    Google Scholar 

  15. Lewis HD, Davis JW, Archibald DG, Steinke WE, Smitherman TC, Doherty JE, Schnaper HW, Lewinter MM, Linares E, Pouget JM, Sabharwal SC, Chesler E, De Mots H (1983) Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. N Engl J Med 309: 396–403

    Article  PubMed  Google Scholar 

  16. Meitzer RS, Visser CA, Fuster V (1986) Intracardiac thrombi and systemic embolization. Ann Intern Med 104: 689–98

    Google Scholar 

  17. Müller P, Dammann HG, Marinis E, Simon B (1990) Gastroduodenale Verträglichkeit von 30 mg versus 300 mg Acetylsalisylsäure täglich. Med Klin 85: 429–431

    Google Scholar 

  18. Prichard PJ, Kitchingman GK, Walt RP, Daneshmend TK, Hawkey CJ (1989) Human gastric mucosal bleeding induced by low dose aspirin, but not warfarin. Br Med J 298: 493–96

    Article  CAS  Google Scholar 

  19. Report of the Sixty Puis Reinfarction Study Research Group (1980) A double-blind trial to assess long-term oral anticoagulant therapy in elderly patients after myocardial infarction. Lancet 2: 989–94

    Google Scholar 

  20. Report of the Working Party on Anticoagulant Therapy in Coronary Thrombosis to the Medical Research Council (1969) Assessment of short-term anticoagulant administration after cardiac infarction. Br Med J 1: 335–341

    Article  Google Scholar 

  21. RISC (1990) Risk of myocardial infarction and death during treatment with low dose aspirin and intravenous heparin in men with unstable coronary artery disease. Lancet 336: 827–830

    Article  Google Scholar 

  22. SCATI (1989) Randomised controlled trial of subcutaneous calcium-heparin in acute myocardial infarction. Lancet 2: 182–186

    Google Scholar 

  23. Serneri GG, Gensini GF, Poggesi L, Trotta F, Modesti PA, Boddi M, Ieri A, Margheri M, Casolo GC, Bini M, Rostagno C, Carnovali M, Abbate R (1990) Effect of heparin, aspirin, or alteplase in reduction of myocardial ischaemia in refractory unstable angina. Lancet 335: 615–618

    Article  Google Scholar 

  24. Smith P, Arnesen H, Holme I (1990) The effect of warfarin on mortality and reinfarction after myocardial infarction. N Engl J Med 323: 147–152

    Article  PubMed  CAS  Google Scholar 

  25. Telford AM, Wilson C (1981) Trial of heparin versus atenolol in prevention of myocardial infarction in intermediate coronary syndrome. Lancet 1: 1225–1228

    Article  PubMed  CAS  Google Scholar 

  26. Théroux P, Ouimet H, McCans J, Latour JG, Joly P, Lévy G, Pelletier E, Juneau M, Stasiak J, deGuise P, Pelletier GB, Rinzler D, Waters DD (1988) Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med 319: 1105–1111

    Article  PubMed  Google Scholar 

  27. Turpie AGG, Robinson JG, Doyle DJ, Mulji AS, Mishkel GJ, Sealey BJ, Crains BJ, Skingley L, Hirsh J, Gent M (1989) Comparison of high-dose with low-dose subcutaneous heparin in the prevention of left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction. N Engl J Med 320: 352–357

    Article  PubMed  CAS  Google Scholar 

  28. Veterans Administration Cooperative Investigators (1973) Anticoagulants in acute myocardial infarction: results of a cooperative clinical trial. JAMA 225: 724–731

    Article  Google Scholar 

  29. Warlow C, Beatie AG, Terry G, Ogston D, Kenmure ACF, Douglas AS (1973) A double-blind trial of low doses of subcutaneous heparin in the prevention of deep-vein thrombosis after myocardial infarction. Lancet 2: 934–939

    Article  PubMed  CAS  Google Scholar 

  30. White HD (1990) GISSI-2 and the heparin controversy. Lancet 336: 297–298

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Dr. Dietrich Steinkopff Verlag, GmbH Co. KG, Darmstadt

About this paper

Cite this paper

Riess, H. (1991). Therapie des Postinfarktpatienten mit Antikoagulanzien und Thrombozytenfunktionshemmern. In: Schmidt, G. (eds) Medikamentöse Behandlung des Postinfarktpatienten nach CAST. Steinkopff. https://doi.org/10.1007/978-3-642-85414-9_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85414-9_15

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-85415-6

  • Online ISBN: 978-3-642-85414-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics