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Sepsis-Related Problems in Pediatric Patients

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Sepsis

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 18))

Abstract

The physiologic changes that constitute the process of sepsis are induced by microbial agents during bloodstream infection or by the toxic products of pathogens that are released from sites of focal infection. This process involves changes generated by the immune system and controlled by hormones, cytokines and enzymes. There are many host and microbial factors that may unfavorably influence this complex immune response. Underlying diseases with immunosuppressive effects, surgery, state of nutrition, immunomodulatory therapy and site of infection increase the risk for development of invasive disease and determine the extent of the immune response [1–3]. However, sepsis in the pediatric population occurs very frequently in previously healthy children. Also, in comparison with adults, the sepsis is more overwhelming. Mortality is mainly confined to the first 48 h of the disease. In children vs adults, different pathogens are involved and the quality and quantity of the immune response depend on the age of the child. These differences are probably caused by developmental aspects of several organ systems and may have special consequences for management and therapy.

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Authors
  1. J. A. Hazelzet
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  2. R. de Groot
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Editors and Affiliations

  1. Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller-Universität Jena, Bachstraße 18, 07740, Jena, Germany

    Konrad Reinhart

  2. Klinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Steglitz der FU Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Klaus Eyrich

  3. Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University, Medical Center, P. O. Box 12000, 91120, Jerusalem, Israel

    Charles Sprung (Direktor) (Direktor)

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© 1994 Springer-Verlag Berlin Heidelberg

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Hazelzet, J.A., de Groot, R. (1994). Sepsis-Related Problems in Pediatric Patients. In: Reinhart, K., Eyrich, K., Sprung, C. (eds) Sepsis. Update in Intensive Care and Emergency Medicine, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85036-3_16

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  • DOI: https://doi.org/10.1007/978-3-642-85036-3_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85038-7

  • Online ISBN: 978-3-642-85036-3

  • eBook Packages: Springer Book Archive

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