Skip to main content
SpringerLink
Log in

Biosynthetic Growth Hormone: Impact on Nitrogen Metabolism and Muscle Function in Stressed Patients

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1993

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 1993 ((YEARBOOK,volume 1993))

Abstract

Severe and prolonged stress, such as that witnessed in critical care patients, results in a negative nitrogen balance associated with a drastic reduction of body muscle mass, strength and endurance. This can lead to prolonged mechanical Ventilation, hospitalization, and increased morbidity. Nutritional supplementation has been shown to improve outcome in such patients [1]. However, in many patients, negative nitrogen balance and muscle wasting persist in spite of nutritional support [2], This has lead to explore the potential benefits, in such situations, of anabolic hormones. Among these, pituitary growth hormone (GH) is the most powerful. Recently, the biosynthetic growth hormone (rGH) has become available for clinical applications and many reports have shown that it reduces, or even prevents, nitrogen catabolism during prolonged stress [3-13] (Fig. 1). This review discusses the current knowledge and the potential development of rGH utilization in critical care medicine.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Larca L, Greenbaum D (1982) Effectiveness of intensive nutritional regimes in patients who fail to wean from mechanical Ventilation. Crit Care Med 10: 297–300

    Article  PubMed  CAS  Google Scholar 

  2. Cerra F, Siegel J, Coleman B, et al. (1980) A failure of exogenous nutritional support. Ann Surg 192: 570–579

    Article  PubMed  CAS  Google Scholar 

  3. Douglas RG, Humberstone DA, Haystead A, Shaw JHF (1990) Metabolic effects of recombinant human growth hormone: Isotopic studies in the postabsorptive State and during total parenteral nutrition. Brit J Surg 77: 785–790

    Article  PubMed  CAS  Google Scholar 

  4. Herndon DN, Barrow RE, Kunkel KR (1990) Effects of recombinant human growth hormone on donor-site healing in severely burned children. Ann Surg 212: 424–429

    Article  PubMed  CAS  Google Scholar 

  5. Jauch KW, Hermann A, Hartl W, Schildberg FW (1992) Dose-dependent effects of human growth hormone (rHGH) on post-operative substrate metabolism. Clin Nutr 11 (Suppl): 9 (Abst)

    Google Scholar 

  6. Jeevanandam M, Ramias L (1990) Plasma growth hormone levels in severely traumatized man. Clin Nutr (Suppl): 5 (Abst)

    Google Scholar 

  7. Jiang Z, He G, Zhang S, et al. (1989) Low dose growth hormone and hypocaloric nutrition attenuate the protein-catabolic response after major Operation. Ann Surg 210: 513–524

    Article  PubMed  CAS  Google Scholar 

  8. Lehner JH, Jauch KW, Berger G, Tacke J, Savic B (1992) A multicentre study of the dose response effect of human recombinant growth hormone on cumulative nitrogen balance in patients after major abdominal surgery. Ann Surg 208: 6–16

    Google Scholar 

  9. Lehmann SL, Teasley KM, Konstantinides NN, Konstantinides F, Cerra FB (1990) Growth hormone enables effective nutrition by peripheral vein in postoperative patients: A pilot study. J Am Coli Nutr 9: 610–615

    CAS  Google Scholar 

  10. Jeevanandam M, Petersen SR, Holaday NJ, Shamos RF (1992) Growth hormone infusion stimulates lipid mobilization and utilization in parenterally fed trauma. Clin Nutr 11 (Suppl): 9 (Abst)

    Google Scholar 

  11. Saito H, Taniwaka K, Muto T, et al. (1992) Effects of growth hormone dose after major surgical Operation: A randomized, prospective, multicentric trial. Clin Nutr 11 (Suppl): 9 (Abst)

    Google Scholar 

  12. Schmeling DJ, Coran AG (1991) Hormonal and metabolic response to operative stress in the neonate. J Parent Enteral Nutr 15: 215–238

    Article  CAS  Google Scholar 

  13. Ziegler TR, Young LS, Ferrari-Baliviera E, Demling RH, Wilmore DW (1990) Use of human growth hormone combined with nutritional support in a critical care unit. J Parent Enteral Nutr 14: 574–581

    Article  CAS  Google Scholar 

  14. Brook CGD (1989) Growth hormone deficiency: Features, assessment, and management. In: DeGroot LJ (ed) Endocrinology, Saunders WB, Philadelphia pp 318–329

    Google Scholar 

  15. Jeevanandam M, Holaday NJ, Petersen SR (1992) Acute insulin-like growth factor deficiency in multiple trauma victims. Clin Nutr 11 (Suppl): 9 (Abst)

    Google Scholar 

  16. Manson JM (1988) Growth hormone stimulates protein synthesis during hypocaloric parenteral nutrition. Surgery 208: 136–142

    CAS  Google Scholar 

  17. Crist DM, Peake GT, Egan PA, Waters DL (1988) Body composition response to exogenous GH during training in highly conditioned adults. Am J Physiol 65: 579–584

    CAS  Google Scholar 

  18. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sönksen PH (1991) Growth hormone treatment in growth hormone-deficient adults. II. Effects on muscle mass and strenght. J Appl Physiol 70: 695–700

    PubMed  CAS  Google Scholar 

  19. Pape G, Friedman M, Underwood LE, ClemmonsDR (1991) The effects of growth hormone on weight gain and pulmonary function in patients with chronic obstructive pulmonary disease. Chest 99: 1495–1500

    Article  PubMed  CAS  Google Scholar 

  20. Horber FF, Haymond MW (1990) Human growth hormone prevents the protein catabolic side effects of prednisolone in humans. J Clin Invest 86: 265–272

    Article  PubMed  CAS  Google Scholar 

  21. Lundeberg S, Beifrage M, Wernerman J, et al. (1991) Growth hormone improves muscle protein metabolism and whole body nitrogen economy in man during a hyponitrogenous diet. Me- tabolism 40: 315–322

    CAS  Google Scholar 

  22. Suchner U, Rothkopf MM, Stanislaus G, et al. (1990) Growth hormone and pulmonary disease. Arch Intern Med 150: 1125–1230

    Article  Google Scholar 

  23. Cuthbertson DP (1979) The metabolic response to injury and its nutritional implications: Retrospect and prospect. I Parent Enterai Nutr 3: 108–129

    Article  CAS  Google Scholar 

  24. Pichard C, Jeejeebhoy KN (1988) Muscle dysfunction in malnourished patients. Quart J Int Med 260: 1021–1045

    Google Scholar 

  25. Laroche CM (1989) Respiratory muscle weakness and fatigue. Quarter J Int Med 265: 373–397

    Google Scholar 

  26. d’A Semple P, Watson WS, Beastall GH, Hume R (1983) Endocrine and metabolic studies in unstable core pulmonale. Thorax 38: 45–49

    Article  PubMed  CAS  Google Scholar 

  27. Dahn MS, Mitchell RA, Smith S (1984) Altered immunologic function and nitrogemnetabolism associated with depression of plasma growth hormone. J Parent Enterai Nutr 8: 690–696

    Article  CAS  Google Scholar 

  28. Ponting GA, Ward HC, Halliday D, Teale JD, Sim AJW (1990) Protein and energy metabolism with biosynthetic growth hormone in patients on füll intravenous nutritional support. I Parent Enterai Nutr 14: 437–441

    Article  CAS  Google Scholar 

  29. Aubier M, Murciano D, Lecocguic Y, et al. (1985) Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. N Engl J Med 313: 420–424

    Article  PubMed  CAS  Google Scholar 

  30. Dahn MS, Lange MP, Jacobs LA (1988) Insulin like growth factor 1 production is inhibited in human sepsis. Arch Surg 123: 1409–1414

    Article  PubMed  CAS  Google Scholar 

  31. Belcher HJ, Ellis H (1990) Somatropin and wound healing after injury. J Clin Endoer Metab 70: 739–743

    Google Scholar 

  32. Bennett C, Reed GW, Peters JC, et al. (1992) Short-term effects of dietary-fat ingestion on energy expenditure and nutrient balance. Am J Clin Nutr 55: 1071–1077

    PubMed  CAS  Google Scholar 

  33. Pichard C, Kyle U, Loizeau E (1992) Place de l’hormone de croissance synthetique dans la prise en Charge nutritionnelle de l’adulte. Rev Med Suisse Rom 112: 517–522

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. C. Pichard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Jolliet
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Pichard, C., Jolliet, P. (1993). Biosynthetic Growth Hormone: Impact on Nitrogen Metabolism and Muscle Function in Stressed Patients. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1993. Yearbook of Intensive Care and Emergency Medicine 1993, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84904-6_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84904-6_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56463-8

  • Online ISBN: 978-3-642-84904-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation