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Vaccine Strategies for the Prevention of Cytomegalovirus Disease

  • Chapter
Molecular Aspects of Human Cytomegalovirus Diseases

Part of the book series: Frontiers of Virology ((FRVIROLOGY,volume 2))

Summary

The theorectical basis for vaccine immunoprophylaxis against cytomegalovirus rests on observations that naturally immune hosts are protected from disease, even though they may not be protected from infection per se. Indirect support for the vaccine paradigm derives from experimental models in the mouse and guinea pig, although these models are imperfect since they necessarily involve infection with species-specific cytomegaloviruses. Direct evidence is now available with the completion of a randomized, double-blind, placebo-controlled trial of Towne strain live attenuated vaccine in renal transplant patients. In seronegative patients who received kidneys from seropositive donors, the vaccine was able to prevent severe disease, albeit not infection; this is analogous to the protection afforded by natural immunity. Because theoretical safety concerns about a live herpesvirus vaccine exist, there is interest in developing noninfectious subunits that would mimic or exceed the immunogenicity of live whole virus. The abundant envelope glycoprotein gB is currently the most promising candidate, but other subunits, including immediate early proteins and other surface glycoproteins, are being investigated. Future work will concentrate on further study of the protective immune response to natural infection, testing live vaccines in other susceptible populations, and developing optimal vectors for the delivery of immunogenic subunits.

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Authors and Affiliations

  1. Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky, KY, 40292, USA

    Gary S. Marshall

  2. Pasteur-Merieux Serums et Vaccins, Marnes-la-Coquette, France

    Stanley A. Plotkin

  3. Connaught Laboratories, Swiftwater, PA, USA

    Stanley A. Plotkin

  4. Willowdale, Ontario, Canada

    Stanley A. Plotkin

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  1. Gary S. Marshall
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Editors and Affiliations

  1. Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, POB 1172, 910010, Jerusalem, Israel

    Yechiel Becker

  2. Institut für Medizinische Virologie, Universität Heidelberg, Im Neuenheimer Feld 324, W-6900, Heidelberg, Germany

    Gholamreza Darai

  3. Lineberger Comprehensive Cancer Research Center, The University of North Carolina, CB # 7259, Rm. 117, Lineberger Building, 27599-7295, Chapel Hill, NC, USA

    Eng-Shang Huang Ph. D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Marshall, G.S., Plotkin, S.A. (1993). Vaccine Strategies for the Prevention of Cytomegalovirus Disease. In: Becker, Y., Darai, G., Huang, ES. (eds) Molecular Aspects of Human Cytomegalovirus Diseases. Frontiers of Virology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84850-6_15

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  • Online ISBN: 978-3-642-84850-6

  • eBook Packages: Springer Book Archive

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