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Detection of Human T-cell Leukemia Viruses

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Diagnosis of Human Viruses by Polymerase Chain Reaction Technology

Part of the book series: Frontiers of Virology ((FRVIROLOGY,volume 1))

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Summary

Human T-cell leukemia/lymphoma virus type I (HTLV-I) is the cause of adult T-cell leukemia/lymphoma (ATL) and a chronic neurologic syndrome It occurs worldwide but with clusters of high seroprevalence in Japan, Africa, and the Caribbean. A related virus known as HTLV-II occurs in endemic clusters in New World Indian populations and is very common among intravenous drug users in some regions. HTLV-II accounts for about half of all HTLV seropositivity in the USA. HTLV-II is not known to be a pathogen Serologic reagents for the detection of these viruses, made from lysates of HTLV-I-infected cells, are believed to be very sensitive to HTLV-I infection Their sensitivity to HTLV-II is largely unknown. Highly sensitive polymerase chain reaction (PCR) detection systems are available and are particularly useful for the evaluation of sérologie tests, for distinguishing HTLV-I from HTLV-II, for determining whether or not infection is present in patients with incomplete or absent seroreactivity or in the obligately seropositive children of seropositive mothers.

Serologic reagents for the detection of these viruses, made from lysates of HILV-I-infected cells, are believed to be very sensitive to HTLV-I infection Their sensitivity to HTLV-II is largely unknown. Highly sensitive polymerase chain reaction (PCR) detection systems are available and are particularly useful for the evaluation of serologic tests, for distinguishing HTLV-I from HTLV-II, for determining whether or not infection is present in patients with incomplete or absent seroreactivity or in the obligately seropositive children of seropositive mothers.

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Authors and Affiliations

  1. Department of Pathology, University of New Mexico School of Medicine, 915 Camino de Salud NE, Albuquerque, NM, 87131, USA

    Brian Hjelle

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  1. Brian Hjelle
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Editors and Affiliations

  1. Department of Molecular Virology Faculty of Medicine, Hebrew University of Jerusalem, POB 1172, Jerusalem, Israel

    Yechiel Becker

  2. Institut für Medizinische Virologie, der Universität Heidelberg, Im Neuenheimer Feld 324, W-6900, Heidelberg, Germany

    Gholamreza Darai

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© 1992 Springer-Verlag Berlin Heidelberg

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Hjelle, B. (1992). Detection of Human T-cell Leukemia Viruses. In: Becker, Y., Darai, G. (eds) Diagnosis of Human Viruses by Polymerase Chain Reaction Technology. Frontiers of Virology, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84766-0_4

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  • DOI: https://doi.org/10.1007/978-3-642-84766-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84768-4

  • Online ISBN: 978-3-642-84766-0

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