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Cytokines and Cytokine Antagonists in Sepsis and Critical Illness

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Yearbook of Intensive Care and Emergency Medicine 1992

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1992))

Abstract

Mediators of the cytokine class are widely assumed to exert significant pathophysiological influences in septic and critically ill patients [1]. Among the cytokines exhibiting significant proinflammatory characteristics, tumor necrosis factor (TNF) and interleukin-1 (IL-1) appear to be the most promising candidate mediators for promoting both the acute septic responses and the organ failure sequelae of sepsis. However, several prospective studies seeking to determine the incidence of circulating TNF and IL-1 in critically ill patients have failed to consistently detect these cytokines during clinical conditions consistent with their known biological functions [2, 3].

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Authors
  1. S. F. Lowry
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  2. L. L. Moldawer
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Editor information

Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1992 Springer-Verlag Berlin Heidelberg

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Lowry, S.F., Moldawer, L.L. (1992). Cytokines and Cytokine Antagonists in Sepsis and Critical Illness. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1992. Yearbook of Intensive Care and Emergency Medicine, vol 1992. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84734-9_4

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  • DOI: https://doi.org/10.1007/978-3-642-84734-9_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55241-3

  • Online ISBN: 978-3-642-84734-9

  • eBook Packages: Springer Book Archive

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