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Recent advances in the molecular biology of Cryptococcus neoformans

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Molecular Biology and its Application to Medical Mycology

Part of the book series: NATO ASI Series ((ASIH,volume 69))

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Abstract

Cryptococcus neoformans is the causative agent of cryptococcosis. Once a rare disease seen only in the terminally ill, it became much more common with the advent of immunosuppressive regimens for the treatment of neoplastic disease and for transplant maintenance. The disease has taken on added importance as one of the most common opportunistic infections seen in patients with AIDS. Anti-cryptococcal therapy is difficult in AIDS patients due to decreased cure rates and increased relapse rates. This increased incidence of cryptococcosis has lead to increased interest in the mechanism of pathogenesis and virulence.

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References

  • Bhattacharjee AK, Kwon-Chung KJ and Glaudemans CPJ (1979) The structure of the capsular polysaccharide of Cryptococcus neoformans serotype D. Carbohydr Res 73: 183–192.

    Article  PubMed  CAS  Google Scholar 

  • Blackburn EH (1990) Telomeres: structure and synthesis. J Biol Chem 265: 5919–5921.

    PubMed  CAS  Google Scholar 

  • Cherniak R (1988) Soluble polysaccharides of Cryptococcus neojormans. Curr Top Med Mycol 2: 40–54.

    Article  PubMed  CAS  Google Scholar 

  • Collins J (1981) Instability of palindromic DNA in E coli. Cold Spring Harbor Symp Quant Biol 45: 409.

    PubMed  CAS  Google Scholar 

  • Edman JC (1992) Isolation of telomere-like sequences from Cryptococcus neoformans and their use in high-efficiency transformation. Mol Cell Biol 12:2777–2783.

    PubMed  CAS  Google Scholar 

  • Edman JC and Kwon-Chung KJ (1990) Isolation of the URA5gene from Cryptococcus neoformans var neoformans and its use as a selective marker for transformation. Mol Cell Biol 10: 4538–4544.

    PubMed  CAS  Google Scholar 

  • Fincham JRS (1989) Transformation in Fungi. Microbiol Rev 53: 148–170.

    PubMed  CAS  Google Scholar 

  • Fromtling RA, Shadomy HJ and Jacobson ES (1982) Decreased virulence in stable, acapsular mutants of Cryptococcus neoformans. Mycopathologica 79: 23–29.

    Article  CAS  Google Scholar 

  • Jacobson, ES, Ayers DJ, Harrell AC and Nicholas CC (1982) Genetic and phenotypic characterization of capsule mutants of Cryptococcus neoformans. J Bacteriol 150: 1292–1296.

    PubMed  CAS  Google Scholar 

  • Kwon-Chung KJ (1975) A new genus, Filobasidiella, the perfect state of Cryptococcus neoformans. Mycologia 67: 1197–1200.

    Article  PubMed  CAS  Google Scholar 

  • Kwon-Chung KJ (1977) Heterothallism vs self-fertile isolates of Filobasidiella neoformans (Cryptococcus neoformans) in The black and white yeasts Pan American Health Org Sci Pub 356 Proceedings of the IV Int Conf on Mycoses Washington, DC pp 204-213.

    Google Scholar 

  • Kwon-Chung KJ (1980) Nuclear genotypes of spore chains in Filobasidiella neoformans (Cryptococcus neoformans), Mycologia 72: 418–422.

    Article  PubMed  CAS  Google Scholar 

  • Kwon-Chung KJ and Edman JC (1992) Recent advances in the molecular genetics of Cryptococcus neoformans in New Strategies in Fungal Disease. Churchill Livingstone London pp 195-207.

    Google Scholar 

  • Kwon-Chung KJ, Edman JC and Wickes BL (1992) Genetic association of mating types and virulence in Cryptococcus neoformans. Infect Immun 60: 602–605.

    PubMed  CAS  Google Scholar 

  • Kwon-Chung KJ, Polachek I and Popkin TJ (1982) Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice. J Bacteriol 150: 1414–1421.

    PubMed  CAS  Google Scholar 

  • Kwon-Chung KJ and Rhodes JC (1986) Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans. Infect Immun 51: 218–233.

    PubMed  CAS  Google Scholar 

  • Littman ML and Tsubura E (1959) Effect of degree of encapsulation upon virulence of Cryptococcus neoformans. Proc Soc Exp Biol Med 101: 773–777.

    PubMed  CAS  Google Scholar 

  • Polacheck I, Hearing VJ and Kwon-Chung KJ (1982) Biochemical studies of phenoloxidase and utilization of catecholamines in Cryptococcus neoformans. J Bacteriol 150: 1212–1220.

    PubMed  CAS  Google Scholar 

  • Still CN and Jacobson ES (1983) Recombinational mapping of capsule mutations in Cryptococcus neoformans. J Bacteriol 156: 460–462.

    PubMed  CAS  Google Scholar 

  • Varma A, Edman JC and Kwon-Chung KJ (1992) Molecular and genetic analysis of URA5 transformants of Cryptococcus neoformans. Infect Immun 60:1101–1108.

    PubMed  CAS  Google Scholar 

  • Whelan WL (1987) The genetics of medically important fungi. Crit Rev Microbiol 14: 99–170.

    Article  PubMed  CAS  Google Scholar 

  • Whelan WL and Kwon-Chung KJ (1986) Genetic complementation in Cryptococcus neoformans. J Bacteriol 166: 924–929.

    PubMed  CAS  Google Scholar 

  • White CW and Jacobson ES (1985) Occurrence of diploid strains of Cryptococcus neoformans. J Bacteriol 161: 1231–1232.

    PubMed  CAS  Google Scholar 

  • Zakian VA (1989) Structure and function of telomeres. Ann Rev Genet 23: 579–604.

    Article  PubMed  CAS  Google Scholar 

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© 1993 Springer-Verlag Berlin Heidelberg

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Edman, J.C. (1993). Recent advances in the molecular biology of Cryptococcus neoformans . In: Maresca, B., Kobayashi, G.S., Yamaguchi, H. (eds) Molecular Biology and its Application to Medical Mycology. NATO ASI Series, vol 69. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84625-0_8

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  • DOI: https://doi.org/10.1007/978-3-642-84625-0_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84627-4

  • Online ISBN: 978-3-642-84625-0

  • eBook Packages: Springer Book Archive

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