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The heat shock response of Neurospora crassa

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Molecular Biology and its Application to Medical Mycology

Part of the book series: NATO ASI Series ((ASIH,volume 69))

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Abstract

Nearly every type of cell in all organisms responds to the stress of sublethal heat shock with a major redirection of gene expression that helps to protect the cell against still higher, lethal temperatures (Lindquist, 1986; Lindquist & Craig, 1988). The molecular basis of this heat shock response, as well as responses to certain other physical stresses, centers about rapid synthesis of a unique set of mRNAs and their translation into the characteristic heat shock proteins. At the same time, normal gene transcription becomes repressed, and translation of normal mRNAs is reduced or discontinued. For most plants and microorganisms, this response to high temperature is transient, and they resume normal transcription and translation after a certain period of time at the heat shock temperature, presumably after accumulating sufficient amounts of the heat shock proteins (Lindquist, 1986). Numerous experiments have shown that cells that are exposed to a sublethal heat shock become more resistant to lethally high temperatures, as well as certain other stresses, and the proteins that cells synthesize during heat shock appear, in most cases, to be required for their increased thermotolerance (Plesofsky-Vig & Brambl, 1985).

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Authors and Affiliations

  1. Department of Plant Biology, The University of Minnesota Saint Paul, Minnesota, 55108, USA

    Nora Plesofsky-Vig & Robert Brambl

Authors
  1. Nora Plesofsky-Vig
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  2. Robert Brambl
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Editor information

Editors and Affiliations

  1. International Institute of Genetics and Biophysics, Via Marconi 12, 80125, Naples, Italy

    Bruno Maresca

  2. Division of Infectious Diseases St. Louis, Washington University School of Medicine, Missouri, 63110, USA

    George S. Kobayashi

  3. Research Center for Medical Mycology, Teikyo University School of Medicine, 359 Otsuka, Hachioji-shi, Tokyo, 192-03, Japan

    Hideyo Yamaguchi

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© 1993 Springer-Verlag Berlin Heidelberg

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Plesofsky-Vig, N., Brambl, R. (1993). The heat shock response of Neurospora crassa . In: Maresca, B., Kobayashi, G.S., Yamaguchi, H. (eds) Molecular Biology and its Application to Medical Mycology. NATO ASI Series, vol 69. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84625-0_13

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  • DOI: https://doi.org/10.1007/978-3-642-84625-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84627-4

  • Online ISBN: 978-3-642-84625-0

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