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In Vitro and In Vivo Regulation of Erythropoiesis

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Erythropoietin

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Abstract

Erythropoiesis involves a cascade of differentiation steps that are driven by a variety of glycoproteins, including interleukin-1 alpha (IL-1α) and interleukin-3 (IL-3), the colony-stimulating factors (CSF) and erythropoietin (Epo) [8, 13, 62]. While the CSF induce the proliferation and differentiation of the pluripotent and committed progenitor cells [8], maturation of the late erythroid progenitors and erythroid precursors is mainly controlled by Epo [25].

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  1. A. Ganser
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  2. D. Hoelzer
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  1. Physiologisches Institut, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, 2400, Lübeck 1, Federal Republic of Germany

    Wolfgang Jelkmann  & Andreas J. Gross  & 

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Ganser, A., Hoelzer, D. (1989). In Vitro and In Vivo Regulation of Erythropoiesis. In: Jelkmann, W., Gross, A.J. (eds) Erythropoietin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83745-6_16

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  • DOI: https://doi.org/10.1007/978-3-642-83745-6_16

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