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Renal Artery Stenosis and Renal Polyglobulia

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Erythropoietin

Abstract

Renal polyglobulia is characterized by an excess secretion of erythropoietin by the kidney in the absence of systemic hypoxaemia. A decrease in blood oxygen tension is the principle signal for the production of erythropoietin. The sensor is undoubtedly located in the kidney, however, neither its excact site nor the site of the production and the secretion of erythropoietin are yet fully elucidated. There is growing evidence that renal erythropoietin is produced by peritubular interstitial cells of the outer medulla and the cortex [41], although cultured mesangial cells have been found able to produce the hormone as well [40]. In detail the regulation of the production of erythropoietin is handled elsewhere in this book (Pagel et al., this volume).

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Authors
  1. P. Grützmacher
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  2. W. Schoeppe
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Editors and Affiliations

  1. Physiologisches Institut, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, 2400, Lübeck 1, Federal Republic of Germany

    Wolfgang Jelkmann  & Andreas J. Gross  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Grützmacher, P., Schoeppe, W. (1989). Renal Artery Stenosis and Renal Polyglobulia. In: Jelkmann, W., Gross, A.J. (eds) Erythropoietin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83745-6_10

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  • DOI: https://doi.org/10.1007/978-3-642-83745-6_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83747-0

  • Online ISBN: 978-3-642-83745-6

  • eBook Packages: Springer Book Archive

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