Abstract
The glucocorticoid “steroids” have been employed extensively in the clinical treatment of central nervous system ischemia and trauma. The rationale for their use has mainly centered upon the expectation that they will reduce postischemic or traumatic brain edema. This notion is based upon the rather remarkable reduction of peritumoral brain edema. However, the efficacy of steroids either in relation to their ability to reduce or to promote neurological recovery following stroke or brain (or spinal) injury has been disappointing at best. Some neurologists and neurosurgeons have concluded that the conventional use of steroids in the acute management of CNS ischemia and trauma is not beneficial and is, in fact, fraught with potentially serious side effects. From a pharmacological perspective, there are several reasons that such a conclusion is premature.
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References
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© 1986 Springer-Verlag Berlin Heidelberg
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Hall, E.D., Travis, M.A., Braughler, J.M. (1986). Pharmacological Interventions in CNS Ischemia and Trauma: Studies With High-Dose Methylprednisolone. In: Vincent, J.L. (eds) 6th International Symposium on Intensive Care and Emergency Medicine. Update in Intensive Care and Emergency Medicine, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82801-0_57
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DOI: https://doi.org/10.1007/978-3-642-82801-0_57
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