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Ethionine-Induced Alterations of tRNA Metabolism

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Modified Nucleosides and Cancer

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Abstract

Ethionine, the ethyl analog of methionine, is a hepatoearcinogen when administered chronically in the diet to rats (Farber 1963). Studies with radioactive ethionine revealed that tRNA was the most extensively labeled nucleic acid species after ethionine administration (Farber et al. 1967). Further studies in recent years have led to extremely interesting findings concerning the effect of ethionine on tRNA metabolism.

Supported in part by NIH grant CA 12742

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Abbreviations

SAM:

S-adenosylmethionine

SAH:

S-adenosylhomocysteine

SAE:

S-adenosyletMonine

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Authors and Affiliations

  1. Department of Biochemistry, Biophysics, and Genetics, University of Colorado, Health Sciences Center, 4200 E. Ninth Avenue, Denver, CO, 80262, USA

    S. J. Kerr

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  1. S. J. Kerr
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  1. Zentrallaboratorium für Mutagenitätsprüfung, Deutschen Forschungsgemeinschaft, Breisacher Strasse 33, D-7800, Freiburg, Germany

    Gisela Nass

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© 1983 Springer-Verlag Berlin • Heidelberg

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Kerr, S.J. (1983). Ethionine-Induced Alterations of tRNA Metabolism. In: Nass, G. (eds) Modified Nucleosides and Cancer. Recent Results in Cancer Research/Fortschritte der Krebsforschung/Progrès dans les recherches sur Ie cancer, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81947-6_17

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  • DOI: https://doi.org/10.1007/978-3-642-81947-6_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81949-0

  • Online ISBN: 978-3-642-81947-6

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