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Brustkrebs und Östrogentherapie nach der Menopause in zwei Seniorengemeinden bei Los Angeles

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Langzeitstudien über Nebenwirkungen der Kontrazeption — Stand und Planung

Part of the book series: Medizinische Informatik und Statistik ((MEDINFO,volume 7))

Zusammenfassung

Aufgrund der Information über bekannte Risikofaktoren des Brustkrebs, über Tierexperimente und über Studien der Hormonspiegel in Gruppen mit hohem und niedrigem Risiko ist die Meinung weit verbreitet, daß die hypophysären und gonadalen Hormone, insbesondere Östrogen, bei der Pathogenese des Brustkrebs eine Rolle spielen. Frauen, die Östrogen nach der Menopause bekommen, tragen also möglicherweise ein Risiko für die Entwicklung von Brustkrebs. Wir berichten hier über die Methodologie für eine laufende Fall-Kontroll-Studie in zwei Seniorengemeinden im Bereich Los Angeles, die angelegt wurde, um die prozeduralen Fehler früherer Studien zu überwinden. Eine allererste grobe Analyse der Daten, basierend auf 41 Fällen und 86 Kontrollen, läßt vermuten, daß Frauen, die in der Menopause Östrogen benutzen, insgesamt kein erhöhtes Risiko einer Brustkrebsentwicklung aufweisen. Aber es zeigt sich ein sehr komplexes Bild des Risikos je nach Dosierung und Benutzungsdauer, das einen schützenden Effekt für Frauen mit niedriger kumulativer Dosis möglich erscheinen läßt, aber ebenso ein mäßig erhöhtes Risiko für Frauen mit hoher kumulativer Dosis.

Diese Studie wurde unterstützt durch. Contract No. NO-CP-5 3500, Grant No. PO-ICA 17054-01 u.Grant No.CA 14089-03 des Nat. Cancer Inst.

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Authors
  1. Ronald K. Ross
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  2. Thomas M. Mack
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  3. Annlia Hill
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  4. Veeba R. Gerkins
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  5. Herman Menck
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Editors and Affiliations

  1. Institut für Medizinische Informationsverarbeitung, Statistik und Biomathematik Ludwig-Maximilians-Universität, Marchioninistr. 15, 8000, München 70, Deutschland

    Ursula Kellhammer

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© 1978 Springer-Verlag Berlin · Heidelberg

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Ross, R.K., Mack, T.M., Hill, A., Gerkins, V.R., Menck, H. (1978). Brustkrebs und Östrogentherapie nach der Menopause in zwei Seniorengemeinden bei Los Angeles. In: Kellhammer, U. (eds) Langzeitstudien über Nebenwirkungen der Kontrazeption — Stand und Planung. Medizinische Informatik und Statistik, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81255-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-81255-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08855-4

  • Online ISBN: 978-3-642-81255-2

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