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Cell-Membrane Activation of Macrophage Function

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Lymphocytes, Macrophages, and Cancer

Abstract

During the lifetime of any cell, the cell’s activity varies from one time to the next as the function which it serves are called on by the body. Since cells are complex and have multiple functions, it is unlikely that changes in one function necessarily occur synchronously with changes in other functions. It is therefore apparent that to speak of “activation” of cells is imprecise unless the function which is activated is precisely defined. This has led to some confusion in the macrophage field, where the cells concerned are motile, phagocytic, capable of differentiation and mitosis, and active in both non-specific and specific immune reactions. The term “activated” is most frequently and most acceptably used to refer to a population of macrophages found in vivo under certain experimental conditions, e.g. following injection of Bacillus Calmette-Guérin (BCG) or other stimulants, which, compared to control populations, show enhanced cytotoxic activity, for example against bacteria such as Listeria spp. (25) or against tumour cells (2) or in graft-versus-host reactions (11). These activated macrophages also frequently show other changes, e.g. an increase in phagocytic activity and an increased tendency to spread on substrata (28) or increased metabolic activity (10).

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  1. P. C. Wilkinson
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  1. Institut de Cancérologie et d’Immunogénétique (INSERM), Hôpital Paul-Brousse, 14—16 Av. Paul-Vaillant-Couturier, 94800, Villejuif, France

    Georges Mathé , Irène Florentin  & Marie-Christine Simmler ,  & 

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Wilkinson, P.C. (1976). Cell-Membrane Activation of Macrophage Function. In: Mathé, G., Florentin, I., Simmler, MC. (eds) Lymphocytes, Macrophages, and Cancer. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 56. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81049-7_6

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  • DOI: https://doi.org/10.1007/978-3-642-81049-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81051-0

  • Online ISBN: 978-3-642-81049-7

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