Abstract
The remarkable progress in the control of cancer therapy-related emesis that we have witnessed over the past few years is well reflected in this monograph. At present, in adults submitted to highly emetogenic chemotherapy, nausea and vomiting should be a rare event in the first 24 hours of observation, with only 5% or less of the patients failing antiemetic therapy completely (more than 5 episodes of emesis), and over 60% fully protected from both nausea and vomiting. However, these figures conceal the reality: if one looks at the whole experience of the patient and includes the later days after chemotherapy in the observation period, the results are clearly not as favourable.
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References
Aapro MS, Kirchner V, Terrey JP: Anticipatory eme-sis: the role of granisetron. Br J Cancer 1994 (69): 957–960
Andrews PLR and Davis CJ: The mechanism of erne-sis induced by anti-cancer therapies. In: Andrews PLR and Sanger GJ: Emesis in Anti-Cancer Therapy: Mechanism and Treatment. Chapman & Hall, London 1993 pp 113–161
Martin M, Diaz-Rubio E, Sanchez A et al: The natural course of emesis after carboplatin treatment. Acta Oncologica 1990 (29):593–595
Aapro MS: 5-HT3 receptor antagonists: an overview of their present status and future potential in cancer therapy-induced emesrs. Drugs 1991 (42):551–586
Roila F, Boschetti E, Tonato M et al: Predictive factors of delayed emesis in cisplatin-treated patients and antiemetic activity of metoclopramide or dexa-methasone. Am J Clin Oncol 1991 (14):238–242
Kris MG, Gralla RH, Tyson LB et al: Controlling delayed vomiting: double-blind randomised trial comparing placebo, dexamethasone alone and metoclopramide plus dexamethasone in patients receiving cisplatin. J Clin Oncol 1989 (7): 108–114
Shinkai T, Saijo N, Eguchi K et al: Control of cisplatin-induced delayed emesis with metoclopramide and dexamethasone. A randomised trial. Jpn J Clin Oncol 1989(19/1):40–44
Italian Group for Antiemetic Research: Cisplatin-induced delayed emesis: Pattern and prognostic factors during three subsequent cycles. Ann Oncol 1994(5):585–589
Passalacqua R, Bella M, Monici L et al: Double-blind randomised trial for the control of delayed emesis: a comparison of placebo versus ACTH. Proc Am Soc Clin Oncol 1988 (9):1270
Jones AL, Hill AS, Soukop M et al: Comparison of dexamethasone and ondansetron in the prophylaxis of emesis induced by moderately emetogenic chemotherapy. Lancet 1991 (338):483–487
Kris MG, Tyson LB, Clark RA et al: Oral ondansetron for the control of delayed emesis after cisplatin. Cancer 1992 (70): 1012–1016
De Mulder HM, Seynaeve C, Vermorken JB et al: Ondansetron compared with high-dose metoclopramide in prophylaxis of acute and delayed cisplatin-induced nausea and vomiting. Ann Int Med 1990 (113):834–840
Gandara DR: Progress in the control of acute and delayed emesis induced by cisplatin. Eur J Cancer 1991 (SuppM):S9–S11
Levitt M, Warr D, Yelle L et al: Ondansetron compared with dexamethasone and metoclopramide as antiemetics in the chemotherapy of breast cancer with cyclophosphamide, methotrexate and 5-fluoro-uracil. N Engl J Med 1993 (328): 1081–1084
Kaizer L, Warr D, Hoskins P et al: The effect of schedule and maintenance on the antiemetic efficacy of ondansetron combined with dexamethasone in patients receiving moderately emetogenic chemotherapy. Proc Am Ass Clin Oncol 1992 (11):381
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© 1996 Springer-Verlag Berlin Heidelberg
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Aapro, M.S. (1996). Therapeutic Approach to Delayed Emesis. In: Tonato, M. (eds) Antiemetics in the Supportive Care of Cancer Patients. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80240-9_7
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DOI: https://doi.org/10.1007/978-3-642-80240-9_7
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