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The Mechanism of Emesis Induced by Chemotherapy and Radiotherapy

  • Conference paper
Antiemetics in the Supportive Care of Cancer Patients

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

Abstract

Nausea and vomiting are two of the side-effects of major concern to patients undergoing palliative or curative chemo- or radiotherapy for cancer and both have a variety of deleterious effects on the patient’s quality of life during treatment. Vomiting itself places a considerable physical stress on the body in patients who may already be weakened by their disease and any concomitant surgery. Tearing of the oesophagus (Mallory-Weiss Syndrome) and herniation of the stomach may occur, as can abdominal muscle strain, purpura, fatigue and even fracture of ribs if the vomiting is particularly violent [1]. The main danger is from aspiration of vomitus, although this is considered to be a greater risk in patients vomiting during emergence from anaesthesia.

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  1. Department of Physiology, St George’s Hospital Medical School, Cranmer Terrace, London, SW17 0RE, UK

    Paul L. R. Andrews

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  1. Medical Oncology Division, Policlinico Monteluce, Via Brunamonti, 06122, Perugia, Italy

    Maurizio Tonato M.D.

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Andrews, P.L.R. (1996). The Mechanism of Emesis Induced by Chemotherapy and Radiotherapy. In: Tonato, M. (eds) Antiemetics in the Supportive Care of Cancer Patients. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80240-9_2

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