Skip to main content
SpringerLink
Log in

Antiemetic Therapy in Paediatric Patients

  • Conference paper
Antiemetics in the Supportive Care of Cancer Patients

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

  • 67 Accesses

Abstract

The past three decades have been associated with a dramatic increase in the cure rate for children with malignant disease. This improvement has been the result of, in the main, more intensive chemotherapy and radiotherapy regimens which have been associated with increased toxicity, in particular acute side-effects due to myelosuppression, alopecia and nausea and vomiting.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kris MG, Gralia RJ, Clark RA et al: Incidence, course and severity of delayed nausea and vomiting following the administration of high-dose cisplatin. J Clin Oncol 1985 (3):1379–1384

    PubMed  CAS  Google Scholar 

  2. Madias NE and Harrington JT: Platinum nephrotoxicity. Am J Med 1978 (65):307–314

    Article  PubMed  CAS  Google Scholar 

  3. Coates A, Abraham S, Kaye SB et al: On the receiving end — patient perception of the side-effects of cancer chemotherapy. Eur J Cancer Oncol 1983 (19):203–208

    Article  CAS  Google Scholar 

  4. Laszlo J: Nausea and vomiting as major complications of cancer chemotherapy. Drugs 1983 (25 Suppl 1):1–7

    Article  PubMed  Google Scholar 

  5. Morrow GR: Chemotherapy related nausea and vomiting: etiology and management. CAA Cancer Treat J 1989 (39):89–104

    Article  CAS  Google Scholar 

  6. Roila F, Tonato M, Basurto C: Antiemetic activity of high doses of metochlopramide in cisplatin treated cancer patients: a randomised double-blind trial of the Italian Oncology Group for Clinical Research. J Clin Oncol 1988 (5):141–149

    Google Scholar 

  7. Marty M: Ondansetron and chemotherapy-induced emesis. 3rd National Congress on Neo-adjustment Chemotherapy. Paris, 1991

    Google Scholar 

  8. Andrykowsky MA, Redd WH, Hatfield AK: Development of anticipatory nausea: a prospective analysis. J Consult Clin Psychol 1985 (53):447–454

    Article  Google Scholar 

  9. Nesse RM, Carli T, Curtis GC et al: Pre-treatment nausea in cancer chemotherapy: a conditioned response? Psychosom Med 1990 (42):43–46

    Google Scholar 

  10. Morrow GR: The assessment of nausea and vomiting. Cancer 1984 (53 Suppl 1):2267–2280

    PubMed  CAS  Google Scholar 

  11. Morrow GR and Morrell CM: Behavioural treatment for the anticipatory nausea and vomiting induced by cancer chemotherapy. N Engl J Med 1982 (307): 1476–1480

    Article  PubMed  CAS  Google Scholar 

  12. Kris MG, Gralla RJ, Clark RA et al: Incidence, course and severity of delayed nausea and vomiting following the administration of high-dose cisplatin. J Clin Oncol 1985 (3):1379–1384

    PubMed  CAS  Google Scholar 

  13. Martin M, Diaz-Rubio E, Sanches A et al: The natural course of emesis after carboplatin treatment. Acta Oncol 1990 (29S):593–595

    Article  Google Scholar 

  14. Priestman T: Radiation-induced emesis. Clinician 1988(6/3):40–43

    Google Scholar 

  15. Parson JA, Webster JH, Dowd J: Evaluation of the placebo effect in the treatment of radiation sickness. Acta Radiol 1961 (56):129–140

    Article  Google Scholar 

  16. Morrow GR: The effect of a susceptibility to motion sickness on the side effects of cancer chemotherapy. Cancer 1985 (55):2766–2770

    Article  PubMed  CAS  Google Scholar 

  17. Zelter L, Le Baron S, Zelter PM: The effectiveness of behavioural intervention for reduction of nausea and vomiting in children and adolescents receiving chemotherapy. J Clin Oncol 1984 (2):683–690

    Google Scholar 

  18. Silva KL, Muller PJ, Pearce J: Acute drug-induced extrapyramidal syndromes. Practitioner 1973 (211):316–320

    PubMed  Google Scholar 

  19. Gralia RJ, Itri LM, Pisko SE et al: Anti-emetic efficacy of high dose metaclopramide: randomised trials with placebo and prochlorperazine in patients with chemotherapy induced nausea and vomiting. N Engl J Med 1981 (305):905–909

    Article  Google Scholar 

  20. Sallan SE, Cronin CM, Zelen M et al: Antiemetics in patients receiving chemotherapy for cancer. N Engl J Med 1989 (302):134–138

    Google Scholar 

  21. Bruera ED, Roca E, Cedara L et al: Improved control of chemotherapy induced emesis by addition of dexamethasone to metoclopramide in patients resistant to metoclopramide. Cancer Treat Rep 1983 (67):381

    PubMed  CAS  Google Scholar 

  22. Drapkin RL, Sokol GH, Paladine WJ et al: The antiemetic effect and dose response of dexamethasone in patients receiving cisplatinum. Proc Am Soc Clin Oncol 1982 (199):61

    Google Scholar 

  23. Laszlo J, Clark RA, Hanson DC: Lorazepam in cancer patients treated with cisplatin: A drug having antiemetic, amnesic and anxiolytic effects. J Clin Oncol 1985 (3):864–869

    PubMed  CAS  Google Scholar 

  24. Stevens RF: A review of ondansetron as prophylaxis for chemotherapy and radiotherapy induced emesis in children. In: “Ondansetron” — Clinical Experience in Adults and Children. Hannover 1992 pp 26–32

    Google Scholar 

  25. Pinkerton CR, Williams D, Wooton C et al: 5HT3, antagonist ondansetron — an effective outpatient anti-emetic in cancer treatment. Arch Dis Child 1990 (65/8):822–825

    Article  PubMed  CAS  Google Scholar 

  26. Laupert A: The role of nurses in the nutrition and management of emesis in children with cancer. In: “Ondansetron” — Management of Emesis in Children with Cancer. Hannover 1992 pp 40–43

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Royal Manchester Children’s Hospital, Pendlebury, Manchester, M27 4HA, UK

    Richard F. Stevens

Authors
  1. Richard F. Stevens
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medical Oncology Division, Policlinico Monteluce, Via Brunamonti, 06122, Perugia, Italy

    Maurizio Tonato M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Stevens, R.F. (1996). Antiemetic Therapy in Paediatric Patients. In: Tonato, M. (eds) Antiemetics in the Supportive Care of Cancer Patients. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80240-9_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80240-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80242-3

  • Online ISBN: 978-3-642-80240-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation