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Curing Metastases? Gene and Peptide Therapy

  • Chapter
Attempts to Understand Metastasis Formation III

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 213/3))

Abstract

Major histocompatibility complex (MHC) molecules are peptide receptors. Their function is to collect peptides inside the cell and transport them to the cell surface, where the complex of peptide and MHC molecule may be recognized by T lymphocytes (Rammensee et al. 1993). In normal cells MHC-associated peptides are derived from normal, self proteins. During their differentiation, T cells become tolerant — by elimination or inactivation (anergy) — to complexes of self MHC and self peptides (Von Boehmer 1992). Thus when new peptides derived from infectious agents or changed self proteins occur later, these can be recognized by T cells (Zinkernagel and Dohenty 1974). However, overexpressed, aberrantly expressed, and even normal self proteins can induce T cell responses under conditions which revert anergy (Nanda and Sercarz 1995). Since the specific immune response is regulated by T cells, the trimolecular complex of T cell receptor (TCR), MHC molecule, and peptides serves as a control switch for the immune system. Control of tumor growth and tumor dissemination by the immune system, particularly by the cellular immune system, is the basis for development of antitumor vaccines (Foley 1953; Prehn and Main 1957; Klein et al. 1960; Old et al. 1962). The role MHC molecules and their associated peptides play in tumor contol is important for development of targeted antigen-specific vaccines for cancer therapy.

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  1. Department of Immunology, Weizmann Institute of Science, 76100, Rehovot, Israel

    Lea Eisenbach

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  1. Lea Eisenbach
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  1. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Ursula Günthert Ph.D., P.D.

  2. Virchow Klinikum, Chirurgische Abteilung, Robert-Rössle-Klinik, Max-Delbrück-Centrum Berlin, Lindenberger Weg 80, D-13122, Berlin, Germany

    Peter M. Schlag M.D.

  3. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Straße 10, D-13122, Berlin, Germany

    Walter Birchmeier Ph.D.

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Eisenbach, L. (1996). Curing Metastases? Gene and Peptide Therapy. In: Günthert, U., Schlag, P.M., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation III. Current Topics in Microbiology and Immunology, vol 213/3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80071-9_6

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