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Use of Nitric Oxide Synthase Inhibitors to reverse Hyperdynamic Circulation and MOF

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Role of Nitric Oxide in Sepsis and ADRS

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 24))

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Abstract

Sepsis is the leading cause of morbidity and mortality in critically ill patients [1], The number of cases of this lethal syndrome is increasing as more patients are immunosuppressed, treated with invasive techniques, and bacteria have become refractory to antibiotics [2, 3]. In the US, more than 400000 cases of sepsis are reported each year, and 50% of these patients die during their course of illness [1]. Death occurs mostly within 24 h after diagnosis and is the result of persistent hypotension.

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Authors
  1. M. Booke
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  2. L. D. Traber
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  3. D. L. Traber
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Editors and Affiliations

  1. Department of Surgery, Beth Israel Hospital, 330 Brookline Avenue, 02215, Boston, MA, USA

    M. P. Fink

  2. Department of Anesthesiology and Intensive Care, Lariboisière University Hospital, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France

    Didier Payen

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© 1995 Springer-Verlag Berlin Heidelberg

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Booke, M., Traber, L.D., Traber, D.L. (1995). Use of Nitric Oxide Synthase Inhibitors to reverse Hyperdynamic Circulation and MOF. In: Fink, M.P., Payen, D. (eds) Role of Nitric Oxide in Sepsis and ADRS. Update in Intensive Care and Emergency Medicine, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79920-4_14

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  • DOI: https://doi.org/10.1007/978-3-642-79920-4_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79922-8

  • Online ISBN: 978-3-642-79920-4

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