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Regulatory Interactions Among E2Fs and Cell Cycle Control Proteins

  • Chapter
Transcriptional Control of Cell Growth

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 208))

Abstract

The last few years have seen an explosive growth in research on E2F transcription factors. Originally characterized as cellular proteins that are critical for adenovirus gene expression and replication, E2Fs have come to be seen as central players in the control of the animal cell cycle. This view comes about largely as the result of the remarkable finding that E2Fs are stably bound and regulated by the pRB tumor suppressor protein. The direct connections between E2Fs and the cell cycle control machinery go far beyond the pRB:E2F association, however, and are now realized to comprise a network of interactions among members of the pRB, E2F, cyclin, and cyclin-dependent kinase (cdk) protein families.

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  1. D. Cobrinik

    Present address: Division of Medical Oncology, Department of Medicine, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY, 10032, USA

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  1. Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA, 02142, USA

    D. Cobrinik

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  1. McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 1400 University Avenue, 53706, Madison, WI, USA

    Peggy J. Farnham (Associate Professor of Oncology) (Associate Professor of Oncology)

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Cobrinik, D. (1996). Regulatory Interactions Among E2Fs and Cell Cycle Control Proteins. In: Farnham, P.J. (eds) Transcriptional Control of Cell Growth. Current Topics in Microbiology and Immunology, vol 208. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79910-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-79910-5_2

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