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Thymus-Injektion von Donormilzzellen verhindert die akzelerierte Transplantatabstoßung in sensibilisierten Ratten

Intrathymic Pretreatment with Donor Splenocytes Abrogates Accelerated Allograft Rejection in Sensitized Rats

  • Conference paper
Chirurgisches Forum ’94

Part of the book series: Langenbecks Archiv für Chirurgie ((FORUMBAND,volume 94))

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Zusammenfassung

Eine Thymus-Injektion von Donoralloantigen unter kurzzeitiger Immunsuppression führt in verschiedenen MHC-inkompatiblen Transplantationsmodellen zur spezifischen Immuntoleranz [1,2]. Der Einfluß einer Alloantigeninjektion auf die Transplantatabstoßung in sensibilisierten Empfängern ist jedoch bisher unbekannt Diese Untersuchung analysiert die Wirkung der Alloantigengabe in den Thymus in einem wohldefinierten Modell der akzelerierten Herztransplantatabstoßung in sensibilisierten Ratten [3].

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Literatur

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Authors and Affiliations

  1. Surgical Research Laboratory, Dept. of Surgery, Brigham and Women’s Hospital, Boston, USA

    Dr. med. J. Binder, G. Schmidbauer, S. G. Tullius & J. W. Kupiec-Weglinski

  2. Dept. of Medicine, Harvard Medical School, Brigham and Woman’s Hospital, Boston, USA

    M. H. Sayegh

  3. Klinik für Allgemein- und Throaxchirurgie, Justus-Liebig-Universität Gießen, Deutschland

    Dr. med. J. Binder & G. Schmidbauer

  4. Dept. of Pathology and Immunology, Monash Medical School, Prahran, Australia

    W. W. Hancock

  5. Abteilung für Allgemeinchirurgie, Freie Universität Berlin, Deutschland

    S. G. Tullius

  6. Harvard Medical School, Surgical Research Laboratory, E-1, Dept. of Surgery, Brigham and Women’s Hospital, 25 Shattuck St, Boston, MA, 02115, USA

    Dr. med. J. Binder

Authors
  1. Dr. med. J. Binder
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  2. G. Schmidbauer
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  3. W. W. Hancock
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  4. S. G. Tullius
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  5. M. H. Sayegh
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  6. J. W. Kupiec-Weglinski
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Editor information

Editors and Affiliations

  1. Chirurgische Klinik I, Klinikum der Universität Ulm, Steinhövelstraße 9, D-89075, Ulm, Deutschland

    Hans G. Beger

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© 1994 Springer-Verlag Berlin Heidelberg

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Binder, J., Schmidbauer, G., Hancock, W.W., Tullius, S.G., Sayegh, M.H., Kupiec-Weglinski, J.W. (1994). Thymus-Injektion von Donormilzzellen verhindert die akzelerierte Transplantatabstoßung in sensibilisierten Ratten. In: Beger, H.G. (eds) Chirurgisches Forum ’94. Langenbecks Archiv für Chirurgie, vol 94. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78905-2_64

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  • DOI: https://doi.org/10.1007/978-3-642-78905-2_64

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57846-8

  • Online ISBN: 978-3-642-78905-2

  • eBook Packages: Springer Book Archive

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