Abstract
Microcin B 17 is an antibiotic peptide produced by wild-type Escherichia coli strains carrying pMccB 17 or other related plasmids (Baquero et al., 1978; San Millán et al, 1987). The genes involved in the biosynthesis and secretion of this antibiotic as well as in the regulation of its production are described in an accompanying paper (Moreno et al, 1991). MccB 17 is a glycine-rich peptide of about 3,200 daltons (Davagnino et al., 1986). It inhibits semiconservative DNA replication, induces the SOS repair system, and finally causes DNA degradation (Herrero & Moreno, 1986; Mayo et al, 1988).
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© 1992 Springer-Verlag Berlin Heidelberg
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Hernández-Chico, C., Mayo, O., Vizán, J.L., Laviña, M., Moreno, F. (1992). Uptake and Mode of Action of the Peptide Antibiotic Microcin B17. In: James, R., Lazdunski, C., Pattus, F. (eds) Bacteriocins, Microcins and Lantibiotics. NATO ASI Series, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76974-0_3
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DOI: https://doi.org/10.1007/978-3-642-76974-0_3
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