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The Antiperinuclear Factor (APF) and Antikeratin Antibodies (AKA) in Rheumatoid Arthritis

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Rheumatoid Arthritis

Abstract

The diagnosis of rheumatoid arthritis (RA) is first of all based on clinical manifestations. Serological support for such a diagnosis is not very well established and it is based mainly on the presence of rheumatoid factors (RF). A positive RF test has a predictive value [1] and is related to disease with a more severe outcome [2]. However, RF is also present in other (autoimmune) diseases and in control sera from healthy persons [3]. Therefore, testing for a second RA-specific antibody would be very useful, and might even be necessary for the management of seronegative RA patients.

Part of the work described in this review was supported financially by “Het Nationaal Reumafonds” of The Netherlands.

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Authors and Affiliations

  1. Department of Biochemistry, University of Nijmegen, P.O. Box 9101, NL 6500 HB, Nijmegen, The Netherlands

    R. M. Hoet & W. J. van Venrooij

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  1. R. M. Hoet
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  2. W. J. van Venrooij
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Editor information

Editors and Affiliations

  1. 2. Medizinische Abteilung Zentrum fü Diagnostik und Therapie rheumatischer Erkrankungen, Krankenhaus der Stadt Wien-Lainz und Ludwig Boltzmann Institut für Rheumatologie und Balneologie, Wolkersbergenstraße 1, A-1130, Wien, Austria

    Josef S. Smolen

  2. Medizinische Klinik III mit Poliklinik und Institut für Klinische Immunologie und Rheumatologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstraße 12, W-8520, Erlangen, Germany

    Joachim R. Kalden

  3. Mathilda and Terence Kennedy Institute of Rheumatology, 6 Bute Gardens, W6 7DW, Hammersmith, London, UK

    Ravinder N. Maini

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© 1992 Springer-Verlag Berlin Heidelberg

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Hoet, R.M., van Venrooij, W.J. (1992). The Antiperinuclear Factor (APF) and Antikeratin Antibodies (AKA) in Rheumatoid Arthritis. In: Smolen, J.S., Kalden, J.R., Maini, R.N. (eds) Rheumatoid Arthritis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76189-8_20

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  • DOI: https://doi.org/10.1007/978-3-642-76189-8_20

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  • Print ISBN: 978-3-642-76191-1

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