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Mouse Monoclonal Antibodies Against Candida Albicans and Cryptococcus Neoformans

  • Conference paper
Fungal Cell Wall and Immune Response

Part of the book series: NATO ASI Series ((ASIH,volume 53))

  • 110 Accesses

Abstract

Specific antibodies are necessary for the rapid identification of pathogenic yeasts, the elucidation of the structure of serotypic specific epitopes, and the detection of circulating antigens in patients with disseminated mycoses. Monoclonal antibodies (MAbs) are presently the most efficient probe for these purposes. This review presents the main results on the production and characterization of monoclonal antibodies directed against Candida albicans and Cryptococcus neoformans which are responsible for the major yeast infections in immunocompromised patients.

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References

  • Axelsen NH (1973) Quantitative immunoelectrophoretic methods as tools for a polyvalent approach to standardization in the immunochemistry of Candida albicans. Infect Immun 7: 949–960

    CAS  PubMed Central  PubMed  Google Scholar 

  • Brawner DL, Cutler JE (1984) Variability in expression of a cell surface determinant on Candida albicans as evidenced by an agglutinating monoclonal antibody. Infect Immun 43: 966–972

    CAS  PubMed Central  PubMed  Google Scholar 

  • Brawner DL, Cutler JE (1986) Variability in expression of a cell surface antigen of Candida albicans during morphogenesis. Infect Immun 51: 337–343

    CAS  PubMed Central  PubMed  Google Scholar 

  • Casanova M, Gil ML, Cardenoso L, Martinez JP, Sentandreu R (1989) Identification of wall-specific antigens synthesized during germ tube formation by Candida albicans. Infect Immun 57: 262–271

    CAS  PubMed Central  PubMed  Google Scholar 

  • Casanova M, Martinez JP, La Jean Chaffin W (1990) Fab fragments from a monoclonal antibody against a germ tube mannoprotein block the yeast to mycelium transition in Candida albicans. Infect Immun 58: 3810–3812

    CAS  PubMed Central  PubMed  Google Scholar 

  • Eckert TF, Kozel TR (1987) Production and characterization of monoclonal antibodies specific for Cryptococcus neoformans capsular polysaccharide. Infect Immun 55: 1895–1899

    CAS  PubMed Central  PubMed  Google Scholar 

  • Cherniak R, Reiss E, Turner SH (1982) A galactoxylomannan antigen of Cryptococcus neoformans serotype A. Carbohydr Res 103: 239–250

    Article  CAS  Google Scholar 

  • Dromer F, Charreire J, Contrepois A, Carbon C, Yeni P (1987) Protection of mice against cryptococcosis by anti-Cryptococcus neoformans monoclonal antibody. Infect Immun 55: 749–752

    CAS  PubMed Central  PubMed  Google Scholar 

  • Eckert TF, Kozel TR (1987) Production and characterization of monoclonal antibodies specific for Cryptococcus neoformans capsular polysaccharide. Infect Immun 55: 1895–1899

    CAS  PubMed Central  PubMed  Google Scholar 

  • Fortier B, Hopwood V, Poulain D (1988) Electric and chemical fusions for the production of monoclonal antibodies reacting with the in vivo growth phase of Candida albicans. J Med Microbiol 27: 239–245

    Article  CAS  PubMed  Google Scholar 

  • Fukazawa Y, Shinoda T, Nishikawa A, Kagaya K, Yonezawa Y (1976) Serological and immunological studies of the serotypes of Candida albicans. In: Iwata K (Ed), Yeasts and yeast-like microorganisms in medical science. Tokyo University Press, Tokyo, p 213

    Google Scholar 

  • Hall NK, Blackstock R (1981) Production of specific antibody to Cryptococcus neofonnans by hybridomas in vitro. Sabouraudia 19: 157–160

    Article  CAS  PubMed  Google Scholar 

  • Ikeda R, Nishikawa A, Shinoda T, Fukazawa Y (1985) Chemical characterization of capsular polysaccharide from Cryptococcus neofonnans serotype A-D. Microbiol Immunol 29: 981–985

    Article  CAS  PubMed  Google Scholar 

  • Ikeda R, Shinoda R, Fukazawa Y, Kaufman L (1982) Antigenic characterization of Cryptococcus neoformans serotypes and its application to serotyping of clinical isolates. J Clin Microbiol 16: 22–29

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lebecq JC, Salhi SL, Bastide JM (1984) A novel antibody overlay technique for two-dimensional immunoelectrophoresis. J Immunol Methods 66: 219–226

    Article  CAS  PubMed  Google Scholar 

  • Miyakawa Y, Kagaya K, Fukazawa Y, Soe G (1986) Production and characterization of agglutinating monoclonal antibodies against predominant antigenic factors for Candida albicans. J Clin Microbiol 23: 881–886.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Munoz C, Mazie JC, Delga JM, Dupont B, Latgé JP, Drouhet E (1988) Monoclonal antibodies anti-Candida albicans mannan and anti Aspergillus fumigatus galactomannan. In: Drouhet E, Cole GT, de Repentigny L, Latgé JP, Dupont B (Eds) Fungal antigens. Plenum Press, New York London, p 213

    Chapter  Google Scholar 

  • Polonelli L, Morace G (1986) Specific and common antigenic determinants of Candida albicans isolates detected by monoclonal antibody. J Clin Microbiol 23: 366–368

    CAS  PubMed Central  PubMed  Google Scholar 

  • Reiss E, Cherniak R, Eby R, Kaufman L (1984) Enzyme immunoassay detection of IgM to galactoxylomannan of Cryptococcus neofonnans. Diag Immunol 2: 109–115

    CAS  Google Scholar 

  • Reiss E, de Repentigny L, Kuykendall RJ, Carter AW, Galindo R, Auger P, Bragg SL, Kaufman L (1986) Monoclonal antibodies against Candida tropicalis mannan• antigen detection by enzyme immunoassay and immunofluorescence. J Clin Microbiol 24: 796–802

    CAS  PubMed Central  PubMed  Google Scholar 

  • Salhi SL, Bastide JM (1988) Immunochemistry of Candida albicans antigens. In: Drouhet E, Cole GT, De Repentigny L, Latgé JP, Dupont B (Eds) Fungal antigens. Plenum Press, New York London, p 141

    Chapter  Google Scholar 

  • Sanford JE, Lupan DM, Schlageter AM, Kozel TR (1990) Passive immunization against Cryptococcus neoformans with an isotype-switch family of monoclonal antibodies reactive with cryptococcal polysaccharide. Infect Immun 58: 1919–1923

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schlageter AM, Kozel TR (1990) Opsonization of Cryptococcus neoformans by a family of isotype-switch variant antibodies specific for the capsular polysaccharide. Infect Immun 58: 1914–1918

    CAS  PubMed Central  PubMed  Google Scholar 

  • Shinoda T, Suzuki Y, Ikeda R, Nishikawa A (1988) Production and serological characterization of monoclonal antibodies against Cryptococcus neofonnans serotype A capsular polysaccharide. Xth Congress of the ISHAM, Barcelona, July 1988, Abstract P-214

    Google Scholar 

  • Spiropulu C, Eppard RA, Otteson E, Kozel TR (1989) Antigenic variation within serotypes of Cryptococcus neoformans detected by monoclonal antibodies specific for the capsular polysaccharide. Infect Immun 57: 3240–3242

    CAS  PubMed Central  PubMed  Google Scholar 

  • Strockbine NA, Largen MT, Zweibel SM, Buckley HR (1984a) Identification and molecular weight characterization of antigens from Candida albicans that are recognized by human sera. Infect Immun 43: 715–721

    CAS  PubMed Central  PubMed  Google Scholar 

  • Strockbine NA, Largen MT, Buckley HR (1984b) Production and characterization of three monoclonal antibodies to Candida albicans proteins. Infect Immun 43: 1012–1018

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sundstrom PM, Tam MR, Nichols ET, Kenny GE (1988) Antigenic differences in the surface mannoproteins of Candida albicans as revealed by monoclonal antibodies. Inf Immun 56: 601–606

    CAS  Google Scholar 

  • Todaro-Luck F, Reiss E, Cherniak R, Kaufman L (1989) Characterization of Cryptococcus neoformans capsular glucuronoxylomannan polysaccharide with monoclonal antibodies. Infect Immun 57: 3882–3887

    CAS  PubMed Central  PubMed  Google Scholar 

  • Tojo M, Shibata N, Kobayashi M, Mikami T, Suzuki M, Suzuki S (1988) Preparation of monoclonal antibodies reactive with ß-1,2-linked oligomannosyl residues in the phosphomannan-protein complex of Candida albicans NIH.B-792 strain. Clin Chem 34: 539–543

    CAS  PubMed  Google Scholar 

  • Tsuchiya T, Kawakita S, Udagawa M (1963) Rapid identification of Cryptococcus neoformans by serology. Sabouraudia 2: 209–214

    Article  Google Scholar 

  • Tsuchyia T, Fukazawa Y, Taguchi M, Nakase T, Shinoda T (1974) Serologic aspects of yeast classification. Mycopathol Mycol Appl 53: 77–91

    Article  Google Scholar 

  • Turner SH, Cherniak R, Reiss E (1984) Fractionation and characterization of galactoxylomannan from Cryptococcus neofonnans. Carbohydr Res 125: 343–349

    Article  CAS  PubMed  Google Scholar 

  • Van de Moer A, Salhi SL, Cherniak R, Pau B, Garrigues ML, Bastide JM (1990) An anti-Cryptococcus neoformans monoclonal antibody directed against galactoxylomannan. Res Immunol 141: 33–42

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. University of Montpellier I, Montpellier, France

    J.-M. Bastide

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  1. J.-M. Bastide
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Editor information

Editors and Affiliations

  1. Institut Pasteur, Unité de Mycologie, 25, rue du Dr. Roux, 75724, Paris Cedex 15, France

    J. P. Latgé

  2. Dept. of Entomology and Nematology, University of Florida, 32611-0711, Gainesville, FL, USA

    D. Boucias

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© 1991 Springer-Verlag Berlin Heidelberg

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Bastide, JM. (1991). Mouse Monoclonal Antibodies Against Candida Albicans and Cryptococcus Neoformans . In: Latgé, J.P., Boucias, D. (eds) Fungal Cell Wall and Immune Response. NATO ASI Series, vol 53. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76074-7_15

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  • DOI: https://doi.org/10.1007/978-3-642-76074-7_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76076-1

  • Online ISBN: 978-3-642-76074-7

  • eBook Packages: Springer Book Archive

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