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Analysis of Hepadnavirus Gene Expression, Biology, and Pathogenesis in the Transgenic Mouse

  • Chapter
Hepadnaviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 168))

Abstract

Hepatitis B virus (HBV) causes acute and chronic hepatocellular injury and hepatocellular carcinoma (reviewed in Chisari et al. 1989b). During acute infection the virus replicates episomally within infected cells. In chronic infection the virus may also integrate into the host cell genome. In HBV-induced hepatocellular carcinoma, integrated viral DNA sequences are virtually always present, and the viral and flanking cellular sequences may be rearranged (see chapter by C. E. Rogler, this volume). Many aspects of the biology of HBV infection and the mechanisms whereby it causes liver cell injury and malignant transformation are not well understood, in large part because of the absence of appropriate tissue culture and animal models to study stages of this process. With the recent advent of transgenic mouse technology and the ability to introduce parts or the entirety of the HBV genome into the mouse germline, many of these questions are now approachable.

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Authors and Affiliations

  1. Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    F. V. Chisari

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  1. F. V. Chisari
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Editors and Affiliations

  1. Fox Chase Cancer Center, 7701 Burholme Ave., Philadelphia, PA, 19111, USA

    William S. Mason  & Christoph Seeger  & 

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© 1991 Springer-Verlag Berlin·Heidelberg

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Chisari, F.V. (1991). Analysis of Hepadnavirus Gene Expression, Biology, and Pathogenesis in the Transgenic Mouse. In: Mason, W.S., Seeger, C. (eds) Hepadnaviruses. Current Topics in Microbiology and Immunology, vol 168. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76015-0_5

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  • DOI: https://doi.org/10.1007/978-3-642-76015-0_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76017-4

  • Online ISBN: 978-3-642-76015-0

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