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Liver Structure, Function, and Anatomy: Effects of Hepatitis B Virus

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Hepadnaviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 168))

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Abstract

Hepatitis B virus (HBV) is a common human pathogen that causes extensive morbidity and mortality in human populations throughout the world. Although the virus has been identified in extrahepatic tissues, such as vascular endothelium, bile duct epithelium, bone marrow, and peripheral blood lymphocytes (Blum et al. 1983), the liver is the major and most important site of infection. It is the disruption of the normal anatomy and functions of the liver that leads to a set of clinically and pathologically defined acute and chronic diseases, including acute and chronic hepatitis and cirrhosis. Chronic infection with HBV is also associated with the development of hepatocellular carcinoma, particularly in the setting of a cirrhotic liver. None of these diseases is specific to HBV infection; each can be caused by other infectious and hepatotoxic agents. What is distinctive about HBV is that it can cause all of these diseases as well as no apparent disease. It is this variability in outcome that is both the least understood and the most fascinating to virologists and clinicians.

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Author information

Authors and Affiliations

  1. Gastrointestinal Section, Department of Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA

    J. Israel

  2. Division of Population Sciences, Fox Chase Cancer Center, 7701 Burholme Avenue, 19111, Philadelphia, PA, USA

    W. T. London

Authors
  1. J. Israel
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  2. W. T. London
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Editor information

Editors and Affiliations

  1. Fox Chase Cancer Center, 7701 Burholme Ave., Philadelphia, PA, 19111, USA

    William S. Mason  & Christoph Seeger  & 

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© 1991 Springer-Verlag Berlin·Heidelberg

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Israel, J., London, W.T. (1991). Liver Structure, Function, and Anatomy: Effects of Hepatitis B Virus. In: Mason, W.S., Seeger, C. (eds) Hepadnaviruses. Current Topics in Microbiology and Immunology, vol 168. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76015-0_1

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  • DOI: https://doi.org/10.1007/978-3-642-76015-0_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76017-4

  • Online ISBN: 978-3-642-76015-0

  • eBook Packages: Springer Book Archive

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