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Neue Möglichkeiten der medikamentösen Antiemesistherapie

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Das Rezidiv in der gynäkologischen Onkologie

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Zusammenfassung

Ein zentrales Problem der heutigen Chemotherapie ist das Auftreten von Übelkeit und Erbrechen als Nebenwirkung vieler Zytostatika. Zu den stärksten emetogen wirkenden Chemotherapeutika gehört Cisplatin, wobei bei höheren Dosierungen nahezu alle Patienten erbrechen bzw. unter Übelkeit leiden [2].

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Literatur

  1. Gralla R.J. et al. (1981): Anti-emetic efficacy of high dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med, 305: 905–909

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  2. Hoff von D.D. et al. (1979): Toxic effects of cis-dichlorodiammineplatinum (II) in man. Cancer Treat. Rep 63: 1527–1531.

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  3. Jacobsen P.B., Redd W.H. (1988): The development and management of chemotherapy-related anticipatory nausea and vomiting. Cancer Invest. 6 (3): 329–336.

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  4. Miner W.D., Sanger G.J. (1986): Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism. Br J Pharmacol 88: 497–499

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  5. The treatment of cytostatic drug-induced emesis (1989): Abstract book, Beecham satellite symposium as part od ECCOS, London

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Authors
  1. W. Eiermann
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  2. M. Untch
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  3. C. Steinborn
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Editor information

Editors and Affiliations

  1. Universitäts-Frauenklinik, Hugstetter Straße 55, D-7800, Freiburg, Deutschland

    Hans-Gerd Meerpohl  & Albercht Pfleiderer  & 

  2. Farmitalia Carlo Erba GmbH, Merzhauser Straße 112, D-7800, Freiburg, Deutschland

    Christian Z. Profous

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© 1990 Springer-Verlag Berlin Heidelberg

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Eiermann, W., Untch, M., Steinborn, C. (1990). Neue Möglichkeiten der medikamentösen Antiemesistherapie. In: Meerpohl, HG., Pfleiderer, A., Profous, C.Z. (eds) Das Rezidiv in der gynäkologischen Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75990-1_7

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  • DOI: https://doi.org/10.1007/978-3-642-75990-1_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53016-9

  • Online ISBN: 978-3-642-75990-1

  • eBook Packages: Springer Book Archive

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