Abstract
This chapter is by no means an exhaustive, comprehensive review of cervical cytology. Instead, it is limited to the discussion of the recent advances in respect of some selected topics, such as the introduction of the “Bethesda System” for reporting the cytologic findings in cervicovaginal smears, and the recognition of adenocarcinoma in situ of the cervix and its diagnostic pitfalls. The subject of human papillomavirus infection is discussed in detail in the chapter by T. Okagaki; therefore in the relevant section in this chapter the emphasis is upon the cytologic features that are associated with the infection, and the application of molecular biology techniques to detect and identify the type of human papillomavirus in cytologic samples.
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References
Abrams J, Silverberg SG (1989) The role of intraoperative cytology in the evaluation of gynecologic disease. Pathol Annu 24: 167–187
Abu-Ghazaleh S, Johnston WJ, Creasman ST (1984) The significance of peritoneal cytology in patients with carcinoma of the cervix. Gynecol Oncol 17: 139–148
Allingham JD, King A (1985) Patient characteristics and endocervical cell recovery on Papanicolaou smears. J Fam Pract 20: 185–190
Ayer B, Pacey F, Greenberg M, Bousfield L (1987) The cytologic diagnosis of adenocarcinoma in situ of cervix uteri and related lesions: I. Adenocarcinoma in situ. Acta Cytol 31: 397–411
Ayer B, Pacey F, Greenberg M (1988) The cytologic diagnosis of adenocarcinoma in situ of the cervix and related lesions: II. Microinvasive adenocarcinoma. Acta Cytol 32: 318–324
Barter RA, Waters ED (1970) Cyto and histomorphology of cervical adenocarcinoma in situ. Pathology 2: 33–40
Boon ME, Baak JPA, Kurver PJH, Overdiep SH, Verdonk GW (1981) Adenocarcinoma in situ of the cervix: an underdiagnosed lesion. Cancer 48: 768–773
Boon ME, deGraaff Guilloud JC, Rietveld WJ (1989) Analysis of five sampling methods for the preparation of cervical smears. Acta Cytol 33: 843–848
Bosch BD, Davidson DD, Lanfeld CD, Fife KH (1989) Human papillomavirus features in cervical Papanicolaou smears. Acta Cytol 33: 696–697
Burmeister RE, Fechner RE, Franklin RR (1969) Endosalpingiosis of the peritoneum. Obstet Gynecol 34: 310–318
Covell JL, Corry TB, Feldman PS (1985) Peritoneal washings in ovarian tumors. Potential sources of error in cytologic diagnosis. Acta Cytol 29: 310–316
Creasman WT, Rutledge F (1971) The prognostic value of peritoneal cytology in gynecologic malignant disease. Am J Obstet Gynecol 110: 773–781
Crosby JH, Allsbrook WC Jr, Pantazis CG et al. (1988) Cytology and flow cytometric DNA evaluation of peritoneal washings in gynecologic patients. Acta Cytol 33: 746
Crum C, Fu Y-S, Kurman RJ, Okagaki T, Twiggs LB, Silberberg SG (1989) Editorial board symposium. Practical approach to cervical human papillomavirus-related intraepithelial lesions. Int J Gynecol Pathol 8: 388–399
Detweilder RE, Castilleja RM, Sneige N (1989) Endocervical columnar cells and adequacy of cervical samples: analysis of 43 discordant smears and cervical biopsies.Acta Cytol 33: 730–731
Dorman AS, Danos LM, Caron BL et al. (1985) Detection of Chalmydia trachomatis in Papanicolaou stained smears by an indirect immunoperoxidase method. Acta Cytol 29: 665–670
Duggan MA, Chang-Poon V, Gabos RS et al. (1988) Human papillomavirus DNA determination in cervical smears using dot-blot hybridization and biotinylated with cDNA probes. Acta Cytol 32: 757
Fentanes de Torres E, Guevara EC (1981) Pleuritis by radiation. Acta Cytol 25: 427–429
Friedell GH, McKay DG (1953) Adenocarcinoma in situ of the endocervix. Cancer 6: 887–897
Gaudefroy M, Coliche D (1971) Deux cas de vaginite due a unparasite encore inconnu en pathologie gynecologique. J Sci Med Lille 89: 301–302
Gershenson DM, Silver EG (1990) Serous ovarian tumors of low malignant potential with peritoneal implants. Cancer 65: 578–585
Gondos B, Marshall D, Ostergad DR (1972) Endocervical cells in cervial smears. Am J Obstet Gynecol 114: 833–834
Gupta PK, Lee EF, Erozan YS et al. (1979) Cytologic investigations in Chlamydia infection. Acta Cytol 23: 315–329
Hart WR (1977) Ovarian epithelial tumors of borderline malignancy (carcinoma of low malignant potential). Hum Pathol 8: 541–549
Henry MR, deMesy Jensen KL, Skoglund CD (1989) Chlamydia trachomatis in routine cervical smears: a microscopic and ultrastructural analysis. Acta Cytol 33: 695
Hilding AC (1930) The common cold. Arch Otolaryngol 12: 133–150
Hoffken H, Soost HJ (1981) Cervical cytology as a screening method. In: Dallenbach-Hellweg G (ed) Cervical cancer. Springer, Berlin Heidelberg New York (Current topics in pathology, vol. 70, pp 21–65 )
Hollander DH, Gupta PK (1979) DCT, CCP and pseudoprotozoa. Acta Cytol 23: 258–259
Imachi M, Tsukamoto N, Matsuyama T, Nakano H (1987) Peritoneal cytology in patients with carcinoma of the uterine cervix. Gynecol Oncol 26: 202–207
Jabamoni R, Dodson MC, Blecka LJ, Jaskoski B, O’Leary J (1977) Unusual protozoal infestation of the cervical mucus. Obstet Gynecol 50: 224–227
Jenson AB (1989) Historical perspectives and current perception of human papillomavirus infections. Focus on Human Papillomavirus 1: 1–3
Katz RL, Ferre F, Sneige N et al. (1989) Comparison of the sensitivity of cytomorphology, slot-blot hybridization and polymerase chain reaction for the detection of human papillomavirus in cervical brushings. Acta Cytol 33: 696
Kelsten ML, Chianese D (1988) Multiparamater flow cytometric analysis in the detection of malignant effusions. Acta Cytol 32: 773
Kern WH (1969) Benign papillary structures with psammoma bodies in culdocentesis fluid. Acta Cytol 13: 178–180
Killough BW, Clark AH, Garvin JB (1988) Correlation between cytodiagnosis and the presence of endocervical or squamous metaplastic cells in gynecologic smears. Acta Cytol 32: 758
Kirk RS, Boon ME (1981) A comparison of the efficiency of diagnosis of early cervical carcinoma by general practitioners and cytology screening programs in the Netherlands. Acta Cytol 25: 259–262
Kivlahan C, Ingram E (1986) Papanicolaou smears without endocervical cells: Are they adequate? Acta Cytol 30: 258–260
Koss LG (1979a) Diagnostic cytology and its histopathologic bases, 3rd edn. Lippincott, Philadelphia.
Koss LG (1979b) Effusions in the absence of cancer. In: Koss LG (ed) Diagnostic cytology and its histopathologic bases, 3rd edn. Lippincott, Philadelphia, pp 229–230
Kristensen GB, Holund B, Grinsted P (1989) Efficacy of the Cytobrush versus the cotton swab in the collection of endocervical cells. Acta Cytol 33: 849–851
Krumins I, Young Q, Pacey F, Boustfield L, Mulhearn L (1977) The cytologic diagnosis of adenocarcinoma in situ of the cervix. Acta Cytol 21: 320–329
Lai-Goldman M, Nieberg RK, Wiesmeier E (1988) The Cytobrush ( Zelsmyr) technique in the preparation of routine cervical-vaginal-endocervical smears. Acta Cytol 32: 746
Lee KR (1988) False-positive diagnosis of adenocarcinoma in situ of the cervix. Acta Cytol 32: 276–277
Lee KR, Manna E, Jones MA (1989) Comparative cytologic features of adenocarcinoma in situ of the cervix. Acta Cytol 33: 697
Lindner LE, Geerling S, Nettum JA, Miller SL, Altman KH (1985) The cytologic features of chlamydial cervicitis. Acta Cytol 29: 676–682
Masood S (1989) Use of monoclonal antibody B72.3 as an adjunct in the diagnosis of adenocarcinoma in malignant effusions. Acta Cytol 33: 724–725
McGowan L (1989) Peritoneal fluid washings. Acta Cytol 33: 414–415
McGrew EA, Nanos S (1983) The cytology of serous effusions. In: Keebler CM, Reagan JW (eds) A manual of cytotechnology, 6th edn. American Society of Clinical Pathologists, Chicago, pp 229–230
McGrew EA, Nanos S (1983) The cytology of serous effusions. In: Keebler CM, Reagan JW (eds) A manual of cytotechnology, 6th edn. American Society of Clinical Pathologists, Chicago, pp 229–230
Naib ZM (1970) Cytology of TRIC agent infection of the eye of newborn infants and their mother’s genital tracts. Acta Cytol 14: 390–395
Pacey F, Ayer B, Greenberg M (1988) The cytologic diagnosis of adenocarcinoma in situ of the cervix uteri and related lesions. III. Pitfalls in diagnosis. Acta Cytol 32: 325–330
Papanicolaou GN (1956) Degenerative changes in ciliated cells exfoliating from the bronchial epithelium as a cytologic criterion in the diagnosis of diseases of the lung. NY State J Med 56: 2647–2650
Papanicolaou GN, Traut HF (1943) Diagnosis of uterine cancer by the vaginal smear. Common Wealth Fund, New York
Pinto MM, Bernstein LH, Brogan DA (1988) Measurement of CA-125, carcinoembryonic antigen and alphafetoprotein in ovarian cyst fluids: diagnostic adjunct to cytology. Acts Cytol 32: 747
Ravinsky E (1986) Cytology of peritoneal washings in gynecologic patients. Diagnostic criteria and pitfalls. Acta Cytol 30: 8–16
Ries E (1897) Eine neue Operationsmethode des.Uteruscarcinomas. Z Geburtshilfe Gynaekol 37: 518–532
Rizzo T, Linker G, Schumann GB (1989) Cytologic pitfalls associated with microglandular endocervical hyperplasia. Acta Cytol 33: 738
Roxby CM, Wood M, Martin AM, McHugh M (1986) Ciliated organisms seen in fluid following dialysis. Lancet I: 916
Sampson JA (1930) Postsalpingectomy endometriosis (endosalpingiosis). Am J Obstet Gynecol 20: 443–480
Selvaggi S (1988) Cytology of nonneoplastic cysts of the ovary. Acta Cytol 32: 756
Selvaggi SM, Malviya V, Deppe G, Malone J Jr, Christensen C (1989) Efficacy of the modified Ayre spatula/Zelsmyr Cytobrush versus the modified Ayre spatula/bulb aspirator in the collection of cells from the uterine cervix. Acta Cytol 33: 697–698
Shiina Y (1985) Cytomorphologic and immunocytochemical studies of chlamydial infections in cervical smears. Acta Cytol 29: 683–691
Sidawy MK, Silverberg SG (1987) Endosalpingiosis in female peritoneal washings: a diagnostic pitfall. Int J Gynecol Pathol 6: 340–346
Sidawy MK, Chandra P, Oertel YC (1987) Detached ciliary tufts in female peritoneal washings. A common finding. Acta Cytol 31: 841–844
Sneige N, Fernandez T, Copeland LJ, Katz RL (1986) Müllerian inclusions in peritoneal washings: potential source of error in cytologic diagnosis. Acta Cytol 30: 271–276
Spieler P, Gloor F (1985) Identification of types and primary sites of malignant tumors by examination of exfoliated tumor cells in serous fluid. Comparison with the diagnostic accuracy on small histologic biopsies. Acta Cytol 29: 753–767
Szpak CA, Creasman WT, Vollmer RT, Johnston WW (1981) Prognostic value of cytologic examination of peritoneal washings in patients with endometrial carcinoma. Acta Cytol 25: 640–646
Taylor PT Jr, Anderson WA, Barber SR et al. (1987) The screening Papanicolaou smear: contribution of the endocervical brush. Obstet Gynecol 70: 734–738
The 1988 Bethesda system for reporting cervical/vaginal cytologic diagnoses. Developed and approved at the National Cancer Institute Workshop, Bethesda, Maryland, USA, 12–13 December 1988 (1989) Acta Cytol 33: 567–574
Tutschka BG, Lauchlan SC (1980) Endosalpingiosis. Obstet Gynecol [Suppl] 55: 575–60S
Viciana AL, Mann WJ, Zuna RE (1989) Peritoneal washing cytology in ovarian malignancy: analysis of 211 cases. Acta Cytol 33: 698
von Haam E (1990) Radiation cell changes. In: Weid GL, Keebler CM, Koss LG, Reagan JW (eds) Compendium on diagnostic cytology. Tutorials of cytology, Chicago, Ill, pp 239–253
Ward BE, Burkett B, Peterson C, Franquemont DW, Crum CP (1989) Cytological correlates of cervical papillomavirus infection. Mod Pathol 2: 103A
Yazigi R, Piver MS, Blumenson L (1983) Malignant peritoneal cytology as prognostic indicator in stage I endometrial cancer. Obstet Gynecol 62: 359–362
Zinsser KR, Wheeler JE (1982) Endosalpingiosis in the omentum: a study of autopsy and surgical material. Am J Surg Pathol 6: 109–117
Ziselman EM, Harkavy SE, Hogan M, West W, Atkinson B (1984) Peritoneal washing cytology; uses and diagnostic criteria in gynecologic neoplasms. Acta Cytol 28: 105–110
Zuna RE, Hansen K, Mann W (1988) Peritoneal washing cytology in cervical carcinoma: analysis of 108 patients. Acta Cytol 32: 758–759
Zuna RE, Heimann A, Glantz L, Healy S (1989a) Utility of monoclonal antibody B72.3 in peritoneal washing cytology. Acta Cytol 33: 727–728
Zuna RE, Mitchell ML, Mullick KA, Weijchert WM (1989b) Cytohistologic correlation of peritoneal washing cytology in gynecologic disease. Acta Cytol 33: 327–336
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Sidawy, M.K. (1992). Cytology in Gynecological Disorders. In: Sasano, N. (eds) Gynecological Tumors. Current Topics in Pathology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75941-3_8
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DOI: https://doi.org/10.1007/978-3-642-75941-3_8
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