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Trophoblastic Disease

  • Chapter
Gynecological Tumors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 85))

Abstract

Trophoblastic disease originates from the placental villi and possesses the following features:

  1. 1.

    The paternal genes are inherited, and from the standpoint of graft immunity the disease has the characteristics of a homograft tumor.

  2. 2.

    These tumors produce human chorionic gonadotropin (hCG), and the level of hCG is a valuable marker for diagnosis as well as for assessment of therapeutic effect and remission.

  3. 3.

    Chemotherapy is very effective, and even metastatic cases may be cured by chemotherapy alone.

  4. 4.

    The tumors apparently progress from hydatidiform mole to invasive mole to choriocarcinoma, and therfore by controlling the hydatidiform mole stage it is possible to detect early choriocarcinoma or even prevent its occurrence.

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References

  • Acosta-Sison H (1967) Trophoblastic or chorionic tumors as observed in the Philippines. In: Holland JF, Hreshchyshyn MM (eds) Choriocarcinoma. Springer, Heidelberg Berlin New York, ( UICC Monograph Series, vol 3, pp 33–36 )

    Google Scholar 

  • Athanassiou A, Begent RHG, Newlands Es, Parker D, Rustin GJS, Bagshawe KD (1983) Central nervous system metastases of choriocarcinoma-23 years’ experience at Charing Cross Hospital. Cancer 52: 1728–1735

    Article  PubMed  CAS  Google Scholar 

  • Bagshawe KD (1969) Metastatic Choriocarcinoma. In: Choriocarcinoma. Edward Arnold, London, pp 93–103

    Google Scholar 

  • Bagshawe KD (1977) Treatment of trophoblastic tumors. Recent Results Cancer Res 62: 192–199

    PubMed  Google Scholar 

  • Bagshawe KD (1987) Chemotherapy and general treatment—current and future developments. In: Takagi S, Freidberg V, Haller U, Knapstein PG, Sevin BV (eds) Gynecologic oncology, surgery and urology. Central Foreign Books, Tokyo, pp 243–249

    Google Scholar 

  • Bagshawe KD, Dent J, Webb J (1986) Hydatidiform mole in England and Wales 1973–1983. Lancet 1I: 673–677

    Article  Google Scholar 

  • Bahn RS, Worsham A, Speeg KV, Ascoli M, Rabin D (1981) Characterization of steroid production in cultured human choriocarcinoma cells. J Clin Endocrinol Metab 52: 447–450

    Article  PubMed  CAS  Google Scholar 

  • Brindley CJ, Antoniw P, Newlands ES, Bagshawe KD (1985) Pharmacokinetics and toxicity of the epipodophyllotoxin derivative etoposide in patients with gestational choriocarcinoma and malignant teratoma. Cancer Chemother Pharmacol 15: 66–71

    Article  PubMed  CAS  Google Scholar 

  • Franke HR, Risse EKJ, Kenemans P, Vooijs GR, Stolk JG (1983) Epidemiologic features of hydatidiform mole in the Netherlands. Obsestet Gynecol 62: 613–616

    CAS  Google Scholar 

  • Goldstein DP (1972) The chemotherapy of gestational trophoblastic disease. JAMA 220: 209–213

    Article  PubMed  CAS  Google Scholar 

  • Hammond CB, Borchert LG, Tyrey L, Creasman WT, Parker RT (1973) Treatment of metastatic trophoblastic disease: good and poor progonosis. Am J Obstet Gynecol 115: 451–457

    PubMed  CAS  Google Scholar 

  • Hammond CB, Weed JC, Currie JL (1980) The role of operation in the current therapy of gestational trophoblastic disease. Am J Obstet Gynecol 136: 844–858

    PubMed  CAS  Google Scholar 

  • Hara T, Kaseki S, Tomoda Y, Nishikawa Y, Ishizuka T, Ishizuka N (1986) Determinants of risk for developing invasive mole and choriocarcinoma following hydatidiform mole. Asia Oceania J Obstet Gynecol 12: 241–250

    Article  CAS  Google Scholar 

  • Hertz R (1967) Eight years experience with the chemotherapy of choriocarcinoma and related trophoblastic tumors in women. In: Holland JF, Hreshchyshyn MM (eds) Choriocarcinoma. Springer, Heidelberg Berlin New York (UICC Monograph Series, vol 3, pp 66–71 )

    Google Scholar 

  • Hertz R, Bergenstal DM, Lipsett MB, Price EB, Hilbish TF (1958) Chemotherapy of choriocarcinoma and related trophoblastic tumors in women. JAMA 168: 845–854

    Article  CAS  Google Scholar 

  • Hertz R, Ross GT, Lipsett MB (1963) Primary chemotherapy of nonmetastatic trophoblastic disease in women. Am J Obstet Gynecol 86: 808–814

    PubMed  CAS  Google Scholar 

  • Hirokawa K, Tomoda Y, Kaseki S, Ishizuka T, Nishikawa Y, Goto S (1986) Recurrence of invasive moles and choriocarcinomas. Asia Oceania J Obstet Gynecol 12: 11–20

    Article  CAS  Google Scholar 

  • Ishizuka N (1976) Studies on trophoblastic neoplasia. In: Hirayama T (ed) Cancer in Asia. University of Tokyo Press, Tokyo (Gann Monograph on Cancer Research No 18, pp 203–216 )

    Google Scholar 

  • Izhizuka T, Tomoda Y, Kaseki S, Goto S, Hara T, Kobayashi T (1983) Intracranial metastasis of choriocarcinoma—a clinicopathologic study. Cancer 52: 1896–1903

    Article  Google Scholar 

  • Jacobs PA, Hassold TJ, Matsuyama AM, Newland IM (1978) Chromosome constitutions of gestational trophoblastic disease. Lancet II: 49

    Google Scholar 

  • Kajii T, Ohama K (1977) Androgenetic origin of hydatidiform moles. Nature 286: 633–634

    Article  Google Scholar 

  • Kaseki S (1974) Primary chemotherapy of trophoblastic disease—experience with 123 cases. Acta Obstet Gynecol Jpn 26: 1069–1076

    Google Scholar 

  • Kolstad P, Hognestad J (1965) Trophoblastic tumors in Norway. Acta Obstet Gynecol Scand 44: 80–88

    Article  PubMed  CAS  Google Scholar 

  • Kurman RJ, Young RH, Norris HJ, Main CS, Lawrence WD, Scully R (1984) Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tumor. Int J Gynecol Pathol 3: 101–121

    Article  PubMed  CAS  Google Scholar 

  • Lawler SD, Pickthall VJ, Fisher RA, Povey S, Evans MW, Szulman AE (1979) Genetic studies of complete and partial hydatidiform moles. Lancet 11: 580

    Article  Google Scholar 

  • Li MC, Hertz R, Spencer DB (1956) Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma. Proc Soc Exp Biol Med 93: 361–366

    PubMed  Google Scholar 

  • Llewellyn-Jones D (1965) Trophoblastic tumors—geographical variations in incidence and possible aetiological factors. J Obstet Gynecol Br Commonw 72: 242–248

    Article  CAS  Google Scholar 

  • Lurain JR, Brewer JI, Trok EE, Halpern B (1983) Natural history of hydatidiform mole after primary evacuation. Am J Obstet Gynecol 145: 591–595

    PubMed  CAS  Google Scholar 

  • McCorriston CC (1968) Racial incidence of hydatidiform mole. Am J Obstet Gynecol 101:377–382 Newlands ES (1982) New chemotherapeutic agents in the management of gestational choriocarcinoma. Semin Oncol 9: 239–243

    Google Scholar 

  • Newlands ES, Bagshawe KD (1979) Activity of high-dose cisplatinum in combination with vincristine and methotrexate in drug-resistant gestational choriocarcinoma. A report of 17 cases. Br J Cancer 40: 943–945

    Article  PubMed  CAS  Google Scholar 

  • Newlands ES, Bagshawe KD (1980) Anti-tumor activity of the epipodophyllin derivative VP16–213 in gestational choriocarcinoma. Eur J Cancer 16: 401–405

    PubMed  CAS  Google Scholar 

  • Nishikawa Y, Kaseki S, Tomoda Y, Ishizuka T, Asai Y, Suzuki T, Ushijima H (1985) Histopathologic classification of uterine choriocarcinoma. Cancer 55: 1044–1051

    Article  PubMed  CAS  Google Scholar 

  • Ohama K, Kajii T, Okamoto E et al. (1981) Dispermic origin of XY moles. Nature 292: 551–552

    Article  PubMed  CAS  Google Scholar 

  • Park WW, Lees JC: Choriocarcinoma. A general review, with an analysis of 516 cases. Arch Path 49:73–104, 205–241 (1950)

    Google Scholar 

  • Registration Committee for Trophoblastic Disease of the Japan Society of Obstetrics and Gynecology (1982) Report of the Registration Committee for Trophoblastic Disease. Acta Obstet Gynecol Jpn 34: 1805–1812

    Google Scholar 

  • Registration Committee for Trophoblastic Disease of the Japan Society of Obstetrics and Gynecology (1987) Report of the Registration Committee for Trophoblastic Disease. Acta Obstet Gynecol Jpn 39: 871–880

    Google Scholar 

  • Report of a WHO scientific group (1983) Gestational trophoblastic disease. WHO technical report series 692, Geneva, pp 11–12

    Google Scholar 

  • Report on the study financially assisted by the Cancer Research Fund of the Ministry of Health and Welfare for the fiscal year 1980

    Google Scholar 

  • Ringertz N (1970) Hydatidiform mole, invasive mole and choriocarcinoma in Sweden. Acta Obstet Gynecol Scand 49: 195–203

    Article  PubMed  CAS  Google Scholar 

  • Ross GT, Stolbach LL, Hertz R (1962) Actinomycin D in the treatment of methotrexate-resistant trophoblastic disease in women. Cancer Res 22: 1015–1017

    PubMed  CAS  Google Scholar 

  • Shirley RL, Goldstein DP, Collins JJ (1972) The role of thoracotomy in the management of patients with chest metastases from gestational metastatic disease. J Thorac Cardiovasc Surg 63: 545–550

    PubMed  CAS  Google Scholar 

  • Sugiura M, Goto S, Saito M, Kato S, Hattori S, Tomoda Y (1988) Establishment and characterization of three new human gestational choriocarcinoma cell lines. Acta Obstet Gynecol Jpn 40: 1447–1454

    CAS  Google Scholar 

  • Sung HC, Wu PC, Hu MH, Su HT (1982) Roentgenologic manifestations of pulmonary metastases in choriocarcinoma and invasive mole. Am J Obstet Gynecol 142: 89–92

    PubMed  CAS  Google Scholar 

  • Teoh ES, Dawood MY, Ratnam SS (1971) Epidemiology of hydatidiform mole in Singapore. Am J Obstet Gynecol: 415–420

    Google Scholar 

  • Thomford NR, Woolner LB, Clagett OT (1965) The surgical treatment of metastatic tumors in the lungs. J Thorac Cardiovasc Surg 49: 357–363

    PubMed  CAS  Google Scholar 

  • Tomoda Y, Kaseki S, Goto S, Ishizuka T, Furuhashi Y, Kato S (1986) Approach for attaining complete cure of trophoblastic disease. In: Ichinoe K (ed) Trophoblastic disease. Igaku-Shoin, Tokyo, pp 111–120

    Google Scholar 

  • Wake N, Takagi N, Sasaki M (1978) Androgenesis as a cause of hydatidiform mole. JNCI 60: 51–57

    PubMed  CAS  Google Scholar 

  • Weed JC, Hammond CB (1980) Cerebral metastatic choriocarcinoma: intensive therapy and prognosis. Obstet Gynecol 55: 89–94

    PubMed  Google Scholar 

  • Xu LT, Sun CF, Wang YE, Song HZ (1985) Resection of pulmonary metastatic choriocarcinoma in 43 drug-resistant patients. Ann Thorac Surg 39: 257–259

    Article  PubMed  CAS  Google Scholar 

  • Yamashita K, Wake N, Araki T, Ichinoe K, Kuroda M (1979) Human lymphocyte antigen expression in hydatidiform mole: androgenesis following fertilization by a haploid sperm. Am J Obstet Gynecol 135: 597–600

    PubMed  CAS  Google Scholar 

  • Yen S, MacMahon B (1968) Epidemiologic features of trophoblastic disease. Am J Obstet Gynecol 101: 126–132

    PubMed  CAS  Google Scholar 

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Authors
  1. Y. Tomoda
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  2. T. Ishizuka
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  3. S. Goto
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  4. Y. Furuhashi
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Editor information

Editors and Affiliations

  1. Tohoku University School of Medicine, 3-6-12 Kuromatsu, Izumi-Ku, Sendai 981, Japan

    Nobuaki Sasano MD (Professor Emeritus) (Professor Emeritus)

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© 1992 Springer-Verlag Berlin Heidelberg

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Tomoda, Y., Ishizuka, T., Goto, S., Furuhashi, Y. (1992). Trophoblastic Disease. In: Sasano, N. (eds) Gynecological Tumors. Current Topics in Pathology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75941-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-75941-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75943-7

  • Online ISBN: 978-3-642-75941-3

  • eBook Packages: Springer Book Archive

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