Skip to main content

Endocrine Tumors of the Ovary

  • Chapter
Gynecological Tumors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 85))

Abstract

This chapter will emphasize aspects of the pathology of functioning ovarian tumors that have appeared in the literature of the last 10–15 years, with particular attention to problems in differential diagnosis. Since there is important recent information concerning a variety of ovarian neoplasms with paraendocrine manifestations, tumors in this category will also be discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abeler V, Kjorstad KE, Nesland JM (1988) Small cell carcinoma of the ovary. A report of six cases. Int J Gynecol Pathol 7: 315–329

    Article  PubMed  CAS  Google Scholar 

  • Aguirre P, Scully RE, Delellis RA (1986) Ovarian heterologous Sertoli–Leydig cell tumors with gastrointestinal-type epithelium. An immunohistochemical analysis. Arch Pathol Lab Med 110: 528–533

    PubMed  CAS  Google Scholar 

  • Aguirre P, Thor AD, Scully RE (1989a). Ovarian endometrioid carcinomas resembling sex cordstromal tumors: an immunohistological study. Int J Gynecol Pathol 8: 364–373

    Article  PubMed  CAS  Google Scholar 

  • Aguirre P, Thor AD, Scully RE (1989b) Ovarian small cell carcinoma—histogenetic considerations based on immunohistochemical and other findings. Am J Clin Pathol 92: 140–149

    PubMed  CAS  Google Scholar 

  • Aiba M, Hirayama A, Sakurada M, Naruse K, Ishikawa C, Aiba S (1990) Spironolactone rod-like structure in renin-producing Sertoli cell tumor of the ovary. Surg Pathol 3: 143–149

    Google Scholar 

  • Axiotis CA, Lippes HA, Merino MJ, deLanerolle NC, Stewart AF, Kinder B (1987) Corticotroph cell pituitary adenoma within an ovarian teratoma: a new cause of Cushing’s syndrome. Am J Surg Pathol 11: 218–224

    Article  PubMed  CAS  Google Scholar 

  • Benjamin E, Law S, Bobrow LG (1987) Intermediate filament cytokeratin and vimentin in ovarian sex cord–stromal tumors with correlative studies in adult and fetal ovaries. J Pathol 152: 253–263

    Article  PubMed  CAS  Google Scholar 

  • Bjorkholm E, Pettersson F (1980) Granulosa-cell and theca-cell tumors. The clinical picture and long term outcome for the Radiumhemmet series. Acta Obstet Gynecol Scand 59: 361–365

    Google Scholar 

  • Bjorkholm E, Silfversward C (1980) Theca-cell tumors. Clinical features and prognosis. Acta Radiol Oncol Radiat Phys Biol 19: 241–244

    Google Scholar 

  • Bjorkholm E, Silfversward C (1981) Prognostic factors in granulosa cell tumors. Gynecol Oncol 11: 261–274

    Article  PubMed  CAS  Google Scholar 

  • Bullon A, Arseneau J, Prat J, Young RH, Scully RE (1981) Tubular Krukenberg tumor. A problem in histopathologic diagnosis. Am J Surg Pathol 5: 225–232

    Google Scholar 

  • Chadha S, van der Kwast TH (1989) Immunohistochemistry of ovarian granulosa cell tumors. The value of tissue specific proteins and tumor markers. Virchows Arch [A] 414: 439–445

    Article  CAS  Google Scholar 

  • Ghalvardjian A, Scully RE (1973) Sclerosing stromal tumors of the ovary. Cancer 31: 664–670

    Article  Google Scholar 

  • Civantos F, Rywlin AM (1972) Carcinomas with trophoblastic differentiation and secretion of chorionic gonadotrophins. Cancer 29: 789–798

    Article  PubMed  CAS  Google Scholar 

  • Clement PB, Scully RE (1980) Large solitary luteinized follicle cyst of pregnancy and puerperium. A clinicopathological analysis of eight cases. Am J Surg Pathol 4: 431–438

    Google Scholar 

  • Cocco AE, Conway SJ (1975) Zollinger–Ellison syndrome associated with ovarian mucinous cystadenocarcinoma. N Engl J Med 293: 485–486

    Article  PubMed  CAS  Google Scholar 

  • Dardi LE, Miller AW, Gould VE(1982) Sertoli–Leydig cell tumor with endometrioid differentiation. Case report and discussion of histogenesis. Diagn Gynecol Obstet 4: 227–234

    Google Scholar 

  • Dickersin GR, Kline IW, Scully RE (1982) Small cell carcinoma of the ovary with hypercalcemia. A report of eleven cases. Cancer 49: 188–197

    Google Scholar 

  • Eddie DAS (1967) Hormonal activity with ovarian tumors. J Obstet Gynecol Br Commonw 74: 283–285

    Article  CAS  Google Scholar 

  • Fathalla MF (1967) The occurrence of granulosa and theca tumors in clinically normal ovaries. A study of 25 cases. J Obstet Gynecol Br Commonw 74: 279–282

    Article  Google Scholar 

  • Fox H, Agrawal K, Langley FA (1975) A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. Cancer 35: 231–241

    Article  PubMed  CAS  Google Scholar 

  • Gaffney EF, Majmudar B, Hertzler GL, Zane R, Furlong B, Breding E (1983). Ovarian granulosa cell tumors—immunohistochemical localization of estradiol and ultrastructure, with functional correlations. Obstet Gynecol 61: 311–318

    PubMed  CAS  Google Scholar 

  • Gagnon S, Tetu B, Silva EG, McCaughey WTE (1989). Frequency of a-fetoprotein production by Sertoli–Leydig cell tumors of the ovary: an immunohistochemical study of eight cases. Mod Pathol 2: 63–67

    PubMed  CAS  Google Scholar 

  • Garcia-Villaneuva M, Figuerola NB, del Arbol LR, Ortiz MJH (1990) Zollinger–Ellison syndrome due to a borderline mucinous cystadenoma of the ovary. Obstet Gynecol 75: 549–551

    Google Scholar 

  • Hameed H (1972) Brenner tumor of the ovary with Leydig cell hyperplasia. A histologic and ultrastructural study. Cancer 30: 945–952

    Article  PubMed  CAS  Google Scholar 

  • Hart WR, Kumar N, Crissman JD (1980) Ovarian neoplasms resembling sex cord tumors with annular tubules. Cancer 45: 2352–2363

    Article  PubMed  CAS  Google Scholar 

  • Hayes MC, Scully RE (1987a) Ovarian steroid cell tumor (not otherwise specified): a clinicopathological analysis of 63 cases. Am J Surg Pathol 11: 835–845

    Article  PubMed  CAS  Google Scholar 

  • Hayes MC, Scully RE, (1987b) Stromal luteoma of the ovary: a clinicopathological analysis of 25 cases. Int J Gynecol Pathol 6: 313–321

    Article  PubMed  CAS  Google Scholar 

  • Herrington JB, Scully RE (1983) Endocrine aspects of germ cell tumors. In: Damjanov I, Knowles B, Solter D (eds) The human teratomas. Humana, Clifton, New Jersey, pp 215–229

    Chapter  Google Scholar 

  • Heyd J, Livni N, Herbert D, Mor-Yosef S, Glaser B (1989) Gastrin-producing ovarian cystadeno-carcinoma: sensitivity to secretin and SMS 201–995. Gastroenterology 97: 464–467

    PubMed  CAS  Google Scholar 

  • Hughesdon PE (1983) Lipid cell thecomas of the ovary. Histopathology 7: 681–692

    Article  PubMed  CAS  Google Scholar 

  • Ishikura H, Scully RE (1987) Hepatoid carcinoma of the ovary. A newly described tumor. Cancer 60: 2775–2784

    Google Scholar 

  • Jackson B, Valentine R, Wagner G (1986) Primary aldosteronism due to a malignant ovarian tumor. Aust NZ J Med 16: 69–71

    Article  CAS  Google Scholar 

  • Kallenberg GA, Pesce CM, Norman B, Ratner RE, Silverberg SG (1990) Ectopic hyperprolactinemia resulting from an ovarian teratoma. JAMA 263: 2472–2474

    Article  PubMed  CAS  Google Scholar 

  • Korzets A, Nouriel H, Steiner Z, Griffel B, Kraus L, Freund U, Klajman A (1986) Resistant hypertension associated with a renin-producing ovarian Sertoli cell tumor. Am J Clin Pathol 85: 242–247

    PubMed  CAS  Google Scholar 

  • Kronke E, Parade GW (1938) Morbus Cushing bei ovarial Teratoma. Z Klin Med 134: 698–718

    Google Scholar 

  • Kulkarni JN, Mistry RC, Kamat MR, Chinoy R, Lotlikar RG (1990) Autonomous aldosterone-secreting ovarian tumor. Gynecol Oncol 37: 284–289

    Article  PubMed  CAS  Google Scholar 

  • Kurman RJ, Andrade D, Goebelsmann U, Taylor CR (1978) An immunohistological study of steroid localization in Sertoli–Leydig tumors of the ovary and testis. Cancer 42: 1772–1783

    Article  PubMed  CAS  Google Scholar 

  • Kurman RJ, Goebelsmann U, Taylor CR (1979) Steroid localization in granulosa–theca tumors of the ovary. Cancer 43: 2377–2384

    Article  PubMed  CAS  Google Scholar 

  • Lack EE, Perez-Atayde AR, Murthy ASK, Goldstein DP, Grigler JF, Vawter GF (1981) Granulosa theca cell tumors in premenarchal girls. A clinical and pathologic study of ten cases. Cancer 48: 1846–1854

    Google Scholar 

  • Long TI’, Barton TK, Draffin R, Reeves WJ, McCarty KS (1980) Conservative management of the Zollinger–Ellison Syndrome. Ectopic gastrin production by an ovarian cystadenoma. JAMA 243: 1837–1839

    Google Scholar 

  • Marieb HJ, Spangler S, Kashgarian M, Heiman A, Schwartz ML, Schwartz PE (1983) Cushing’s syndrome secondary to ectopic cortisol production by an ovarian carcinoma. J Clin Endocrinol Metab 57: 737–740

    Article  PubMed  CAS  Google Scholar 

  • Matias-Guiu X, Prat J (1990) Ovarian tumors with functioning stroma. An immunohistochemical study of 100 cases with human chorionic gonadotropin monoclonal and polyclonal antibodies. Cancer 65: 2001–2005

    Article  PubMed  CAS  Google Scholar 

  • Maton PN, Mackern SM, Norton JA, Gardner JD, O’Dorisio TM, Jensen RT (1989) Ovarian carcinoma as a cause of Zollinger–Ellison syndrome. Gastroenterology 97: 468–471

    PubMed  CAS  Google Scholar 

  • McMahon JT, Hart WR (1988) Ultrastructural analysis of small cell carcinomas of the ovary. Am J Clin Pathol 90: 523–529

    PubMed  CAS  Google Scholar 

  • Miettinen M, Talerman A, Wahlstrom T, Astengo-Osuna C, Virtanen I (1985) Cellular differentiation in ovarian sex-cord–stromal and germ-cell tumors studied with antibodies to intermediate-filament proteins. Am J Surg Pathol 9: 640–651

    Article  PubMed  CAS  Google Scholar 

  • Morgan DR, Wells A, MacDonald RC, Johnston D (1985) Zollinger–Ellison syndrome due to a gastrin secreting ovarian mucinous cystadenoma. Case report. Br J Obstet Gynecol 92: 867–869

    Google Scholar 

  • Nakashima N, Young RH, Scully RE (1984) Androgenic granulosa cell tumors of the ovary. A clinicopathological analysis of seventeen cases and review of the literature. Arch Pathol Lab Med 108: 786–791

    Google Scholar 

  • Palmer PE, Bogojavlensky S, Bhan AK, Scully RE (1990) Prolactinoma in wall of ovarian dermoid cyst with hyperprolactinemia. Obstet Gynecol 75: 540–543

    PubMed  CAS  Google Scholar 

  • Paoletti M, Pridjian G, Okagaki T, Talerman A (1987) A stromal Leydig cell tumor of the ovary occurring in a pregnant 15-year-old girl. Ultrastructural findings. Cancer 60: 2806–2810

    Google Scholar 

  • Paraskevas M, Scully RE (1989) Hilus cell tumor of the ovary: a clinicopathological analysis of 12 Reinke-crystal-positive and 9 crystal-negative cases. Int J Gynecol Pathol 8: 299–310

    Article  PubMed  CAS  Google Scholar 

  • Prat J, Young RH, Scully RE (1982) Ovarian Sertoli—Leydig cell tumors with heterologous elements (ii) cartilage and skeletal muscle. A clinicopathologic analysis of twelve cases. Cancer 50: 2465–2475

    Google Scholar 

  • Primrose JN, Maloney M, Wells M, Bulgim O, Johnston D (1988) Gastrin-producing ovarian mucinous cystadenomas: a cause of the Zollinger—Ellison syndrome. Surgery 104: 830–833

    PubMed  CAS  Google Scholar 

  • Rome RM, Laverty CR, Brown JB (1973) Ovarian tumors in postmenopausal women. Clinicopathological features and hormonal studies. J Obstet Gynecol Br Commonw 80: 984–991

    Google Scholar 

  • Rome RM, Fortune DW, Quinn MA, Brown JB (1981) Functioning ovarian tumors in postmenopausal women. Obstet Gynecol 57: 705–710

    PubMed  CAS  Google Scholar 

  • Roth LM, Sternberg WH (1973) Ovarian stromal tumors containing Leydig cells. II. Pure Leydig cell tumor, non-hilar type. Cancer 32: 952–960

    Google Scholar 

  • Roth LM, Sternberg WH (1983) Partly luteinized theca cell tumor of the ovary. Cancer 51: 1697–1704

    Article  PubMed  CAS  Google Scholar 

  • Roth LM, Anderson MC, Govan ADT, Langley FA, Gowing NFC, Woodcock AS (1981) SertoliLeydig cell tumors. A clinicopathologic study of 34 cases. Cancer 48: 187–197

    Article  PubMed  CAS  Google Scholar 

  • Roth LM, Liban E, Czernobilsky B (1982) Ovarian endometrioid tumors mimicking Sertoli and Sertoli—Leydig cell tumors. Sertoliform variant of endometrioid carcinoma. Cancer 50: 1322–1331

    Google Scholar 

  • Roth LM, Slayton RE, Brady LW, Blessing JA, Johnson G (1985) Retiform differentiation in ovarian Sertoli—Leydig cell tumors. A clinicopathologic study of six cases from a gynecologic oncology study group. Cancer 55: 1093–1098

    Google Scholar 

  • Rubin DK, Frost JK (1963) The cytologic detection of ovarian cancer. Acta Cytol 7: 191–195

    PubMed  CAS  Google Scholar 

  • Rutgers J, Scully RE (1986) Functioning ovarian tumors with peripheral steroid cell proliferation: a report of twenty-four cases. Int J Gynecol Pathol 5: 319–337

    Article  PubMed  CAS  Google Scholar 

  • Samaan NA, Smith JP, Rutledge FN, Schultz PN (1976) The significance of measurement of human placental lactogen, human chorionic gonadotropin, and carcinoembryonic antigen in patients with ovarian carcinoma. Am J Obstet Gynecol 126: 186–189

    PubMed  CAS  Google Scholar 

  • Sasano H, Sasano N (1989) What’s new in the localization of sex steroids in the human ovary and its tumors? Pathol Res Pract 185: 942–948

    Article  PubMed  CAS  Google Scholar 

  • Sasano H, Okamoto M, Mason JI, Simpson ER, Mendelson CR, Sasano N, Silverberg SG (1989) Immunohistochemical studies of steroidogenic enzymes (aromatase, 17-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord—stromal tumors of the ovary. Hum Pathol 20: 452–457

    Article  PubMed  CAS  Google Scholar 

  • Scully RE (1970) Sex cord tumor with annular tubules. A distinctive ovarian tumor of the Peutz—Jeghers syndrome. Cancer 25: 1107–1121

    Article  PubMed  CAS  Google Scholar 

  • Scully RE (1979) Tumors of the ovary and maldeveloped gonads. Atlas of tumor pathology; 2nd series, fascicle No. 16. Armed Forces Institute of Pathology, Washington, D.C.

    Google Scholar 

  • Scully RE (1987). Ovarian tumors with functioning stroma. In: Fox H (ed) Haines and Taylor’s gynaecological and obstetrical pathology, 3rd edn. Churchill Livingstone, Edinburgh, pp 724–736

    Google Scholar 

  • Scully RE, Richardson GS (1961) Luteinization of the stroma of metastatic cancer involving the ovary and its endocrine significance. Cancer 14: 827–840

    Article  PubMed  CAS  Google Scholar 

  • Scully RE, Dickersin GR (1989) Letter to the editor. Int J Gynecol Pathol 8: 196

    Google Scholar 

  • Scully RE, Aguirre P, DeLellis RA (1984) Argyrophilia, serotonin, and peptide hormones in the female genital tract and its tumors. Int J Gynecol Pathol 3: 51–70

    Article  PubMed  CAS  Google Scholar 

  • Serov SF, Scully RE, Sobin LH (1973) International histological classification of tumors, No. 9. Histological typing of ovarian tumors. World Health Organization, Geneva

    Google Scholar 

  • Shetty MR, Boghossian HM, Duffell D, Freel R, Gonzales JC (1982) Tumor-induced hypoglycemia: a result of ectopic insulin production. Cancer 49: 1920–1923

    Article  PubMed  CAS  Google Scholar 

  • Solh HM, Azoury RS, Najjar SS (1983) Peutz—Jeghers syndrome associated with precocious puberty. J Pediatr 103: 593–595

    Article  PubMed  CAS  Google Scholar 

  • Stenwig JT, Hazekamp JT, Beecham JB (1979) Granulosa cell tumors of the ovary. A clinicopathological study of 118 cases with long-term follow-up. Gynecol Oncol 7: 136–152

    Article  PubMed  CAS  Google Scholar 

  • Sternberg WH, Roth LM (1973) Ovarian stromal tumors containing Leydig cells. 1. Stromal—Leydig cell tumor and non-neoplastic transformation of ovarian stroma to Leydig cells. Cancer 32: 940–951

    Google Scholar 

  • Susil BJ, Sumithran E (1987) Sarcomatous change in granulosa cell tumor. Hum Pathol 18: 397–399

    Article  PubMed  CAS  Google Scholar 

  • Talerman A (1987) Ovarian Sertoli—Leydig cell tumor (androblastoma) with retiform pattern: a clinicopathologic study. Cancer 60: 3056–3064

    Article  PubMed  CAS  Google Scholar 

  • Talerman A, Hughesdon PE, Anderson MC (1982) Diffuse nonlobular ovarian androblastoma usually associated with feminization. Int J Gynecol Pathol 1: 155–171

    Article  PubMed  CAS  Google Scholar 

  • Tavassoli FA, Norris HJ (1980) Sertoli tumors of the ovary. A clinicopathologic study of 28 cases with ultrastructural observations. Cancer 46: 2281–2297

    Article  PubMed  CAS  Google Scholar 

  • Taylor HB, Norris HJ (1967) Lipid cell tumors of the ovary. Cancer 20: 1953–1962

    Article  PubMed  CAS  Google Scholar 

  • Tracy SL, Askin FB, Reddick RL, Jackson B, Kurman RJ (1985) Progesterone secreting Sertoli cell tumor of the ovary. Gynecol Oncol 22: 85–96

    Article  PubMed  CAS  Google Scholar 

  • Ulbright TM, Roth LM, Stehman FB, Talerman A, Senekjian EK (1987) Poorly differentiated (small cell) carcinoma of the ovary in young women: evidence supporting a germ cell origin. Hum Pathol 18: 175–184

    Article  PubMed  CAS  Google Scholar 

  • Vaitukaitis JL (1974) Human chorionic gonadotropin as a tumor marker. Ann Clin Lab Sci 4: 276–280

    PubMed  CAS  Google Scholar 

  • Waxman M, Vuletin JC, Urcuyo R, Belling CG (1979) Ovarian low-grade stromal sarcoma with thecomatous features: a critical reappraisal of the so-called “malignant thecoma.” Cancer 44: 2206–2217

    Article  PubMed  CAS  Google Scholar 

  • Waxman M, Damjanov I, Alpert L, Sardinsky T (1981) Composite mucinous ovarian neoplasms associated with Sertoli—Leydig and carcinoid tumors. Cancer 47: 2044–2052

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1982) Ovarian sex cord—stromal tumors. Recent progress. Int J Gynecol Pathol 1: 101–123

    Google Scholar 

  • Young RH, Scully RE (1983a) Ovarian Sertoli—Leydig cell tumors with a retiform pattern: a problem in histopathologic diagnosis. A report of 25 cases. Am J Surg Pathol 7: 755–771

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1983b) Ovarian sex cord—stromal tumors with bizarre nuclei. A clinicopathologic analysis of seventeen cases. Int J Gynecol Pathol 1: 325–335

    Google Scholar 

  • Young RH, Scully RE (1983c) Ovarian stromal tumors with minor sex cord elements: a report of seven cases. Int J Gynecol Pathol 2: 227–234

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1984a) Fibromatosis and massive edema of the ovary, possibly related entities. A report of 14 cases of fibromatosis and 11 cases of massive edema. Int J Gynecol Pathol 3: 153–178

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1984b) Ovarian Sertoli cell tumors. A report of ten cases. Int J Gynecol Pathol 2: 349–363

    Google Scholar 

  • Young RH, Scully RE (1984c) Ovarian sex cord—stromal tumors: recent advances and current status. Clin Obstet Gynecol 11: 93–134

    CAS  Google Scholar 

  • Young RH, Scully RE (1984d) Well-differentiated ovarian Sertoli—Leydig cell tumors. A clinico-pathological analysis of 23 cases. Int J Gynecol Pathol 3: 277–290

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1985) Ovarian Sertoli—Leydig cell tumors. A clinicopathological analysis of 207 cases. Am J Surg Pathol 9: 543–569

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1987a) Sex cord—stromal tumors, steroid cell tumors and other ovarian tumors with endocrine, paraendocrine and paraneoplastic manifestations. In: Kurman RJ (ed) Balustein’s pathology of the female genital tract. Springer, New York, pp 607–658

    Google Scholar 

  • Young RH, Scully (1987b) Ovarian steroid cell tumors associated with Cushing’s syndrome. A report of three cases. Int J Gynecol Pathol 6: 40–48

    Google Scholar 

  • Young RH, Scully RE (1987c) Oxyphilic clear cell carcinoma of the ovary. A report of nine cases. Am J Surg Pathol 11: 661–667

    Google Scholar 

  • Young RH, Scully RE (1989) Alveolar rhabdomyosarcoma metastatic to the ovary. A report of two cases and discussion of the differential diagnosis of small cell malignant tumors of the ovary. Cancer 64: 899–904

    Google Scholar 

  • Young RH, Scully RE (1990) Sarcomas metastatic to the ovary. Areport of 21 cases. Int J Gynecol Pathol 9: 231–252

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1991) Malignant melanoma metastatic to the ovary: A clinicopathologic analysis of 20 cases. Am J Surg Pathol, 15: 849–860

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Prat J, Scully RE (1982) Ovarian endometrioid carcinomas resembling sex cord—stromal tumors. A clinicopathological analysis of 13 cases. Am J Surg Pathol 6: 513–522

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Part J, Scully RE (1982b) Ovarian Sertoli—Leydig cell tumors with heterologous elements. (i) Gastrointestinal epithelium and carcinoid: a clinicopathologic analysis of thirty-six cases. Cancer 50: 2448–2456

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Welch WR, Dickersin GR, Scully RE (1982c) Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz—Jeghers syndrome and 4 with adenoma malignum of the cervix. Cancer 50: 1384–1402

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Dickersin GR, Scully RE (1983a) A distinctive ovarian sex cord—stromal tumor causing sexual precocity in the Peutz—Jeghers syndrome. Am J Surg Pathol 7: 223–243

    Google Scholar 

  • Young RH, Prat J, Scully RE (1983b) Endometrioid stromal sarcomas of the ovary. A clinicopathological analysis of twenty-three cases. Cancer 53: 1143–1155

    Google Scholar 

  • Young RH, Dickersin GR, Scully RE (1984a) Juvenile granulosa cell tumor of the ovary. A clinicopathologic analysis of 125 cases. Am J Surg Pathol 8: 575–596

    Article  PubMed  CAS  Google Scholar 

  • Young RH, Dudley AG, Scully RE (1984b) Granulosa cell, Sertoli—Leydig cell and unclassified sex cord—stromal tumors associated with pregnancy. A clinicopathological analysis of thirty-six cases. Gynecol Oncol 18: 181–205

    Google Scholar 

  • Young RH, Perez-Atayde AR, Scully RE (1984c) Ovarian Sertoli-Leydig cell tumor with retiform and heterologous components. Report of a case with hepatocytic differentiation and elevated serum a-fetoprotein. Am J Surg Pathol 8: 709–718

    Google Scholar 

  • Zaloudek C, Norris HJ (1982) Granulosa tumors of the ovary in children. A clinical and pathologic study of 32 cases. Am J Surg Pathol 6: 503–512

    Article  PubMed  CAS  Google Scholar 

  • Zaloudek C, Norris HJ (1984) Sertoli—Leydig tumors of the ovary. A clinicopathologic study of 64 intermediate and poorly differentiated neoplasms. Am J Surg Pathol 8: 405–418

    Article  PubMed  CAS  Google Scholar 

  • Zaloudek CJ, Tavassoli FA, Norris Hi (1981) Dysgerminoma with syncytiotrophoblastic giant cells. A histologically and clinically distinctive subtype of dysgerminoma. Am J Surg Pathol 5: 361–367

    Article  PubMed  CAS  Google Scholar 

  • Zhang J, Young RH, Arseneau J, Scully RE (1982) Ovarian stromal tumors containing lutein or Leydig cells (luteinized thecomas and stromal Leydig cell tumors). A clinicopathological analysis of fifty cases. Int J Gynecol Pathol 1: 270–285

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Young, R.H., Scully, R.E. (1992). Endocrine Tumors of the Ovary. In: Sasano, N. (eds) Gynecological Tumors. Current Topics in Pathology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75941-3_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75941-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75943-7

  • Online ISBN: 978-3-642-75941-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics