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Cervical Intraepithelial Neoplasia and Microinvasive Carcinoma of the Cervix

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Gynecological Tumors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 85))

Abstract

Various epithelial abnormalities may appear in the uterine cervix. Most are only benign changes, such as reserve cell hyperplasia, mature or immature squamous metaplasia, basal cell hyperplasia, ascending healing, and reactive proliferation for inflammation. However, a group of intraepithelial lesions with malignant potential known as dysplasia or carcinoma in situ (CIS) may also occur in the cervix.

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References

  • Abdul-Karim FW, Fu YS, Reagan JW, Wentz WB (1982) Morphometric study of intraepithelial neoplasia of uterine cervix. Obstet Gynecol 60: 210–214

    PubMed  CAS  Google Scholar 

  • Adelusi B, Osunkoya BO, Fabiyi A (1975) Antibodies to herpesvirus type 2 in carcinoma of the cervix uteri in Ibadan, Nigeria. Am J Obstet Gynecol 123: 758–761

    PubMed  CAS  Google Scholar 

  • Anderson MC (1982) Difficulties in colposcopic and histological interpretation. In: Anderson MC (ed) Proceedings of the fourth world congress for cervical pathology and colposcopy. Churchhill Livingstone, London

    Google Scholar 

  • Anderson MC (1987) Obstetrical and gynecological pathology. Churchill Livingstone, London

    Google Scholar 

  • Barron BA, Cahill MC, Richart RM (1978) A statistical model of the natural history of cervical neoplastic disease. The duration of carcinoma in situ. Gynecol Oncol 6: 196–205

    Article  PubMed  CAS  Google Scholar 

  • Bellina JH, Dunlop WP, Riopelle MA (1982) Reliability of histopathologic diagnosis of cervical intraepithelial neoplasia. South Med J 75: 6–8

    Article  PubMed  CAS  Google Scholar 

  • Benson WL, Norris HJ (1977) A critical review of the frequency of lymph node metastases and death from microinvasive carcinoma of the cervix. Obstet Gynecol 49: 632–638

    PubMed  CAS  Google Scholar 

  • Berkeley AS, LiVolsi VA, Schwartz PE (1980) Advanced squamous cell carcinoma of the cervix with recent normal Papanicolaou tests. Lancet 11: 375–376

    Article  Google Scholar 

  • Bibbo M, Dytch HE, Alenhhat E, Bartels PH, Wied G (1989) DNA ploidy profiles as prognostic indicators in CIN lesions. Am J Clin Pathol 92: 261–265

    PubMed  CAS  Google Scholar 

  • Boyes DA, Worth JA, Fidler HK (1970) The results of treatment of 4389 cases of preclinical cervical squamous carcinoma. J Obstet Gynaecol Br Commonw 77: 769–780

    Article  PubMed  CAS  Google Scholar 

  • Buckley CH, Butler EB, Fox H (1982) Cervical intraepithelial neoplasia. J Clin Pathol 35: 1–13

    Article  PubMed  CAS  Google Scholar 

  • Burghardt E (1973) Early histological diagnosis of cervical cancer. Friedman EA (ed) Major problems in obstetrics and gynecology, vol 6. Saunders, Philadelphia

    Google Scholar 

  • Burghardt E (1982) Diagnostic and prognostic criteria in cervical microcarcinoma. Clin Oncol 1: 323–333

    Google Scholar 

  • Burghardt E, Holzer E (1977) Diagnosis and treatment of microinvasive carcinoma of the cervix uteri. Obstet Gynecol 49: 641–653

    PubMed  CAS  Google Scholar 

  • Cocker J, Fox H, Langley FA (1968) Consistency in the histological diagnosis of epithelial abnormalities of the cervix uteri. J Clin Pathol 21: 67–70

    Article  PubMed  CAS  Google Scholar 

  • Cocks PS, Peel KR, Cartwright RA, Adib R (1980) Carcinoma of the penis and cervix (letter). Lancet 11: 855–856

    Article  Google Scholar 

  • Colgan TJ, Percy ME, Suri M, Shier RM, Andrews DR, Lickrish GM (1989) Human papillomavirus infection of morphologically normal cervical epithelium adjacent to squamous dysplasia and invasive carcinoma. Hum Pathol 20: 316–319

    Article  PubMed  CAS  Google Scholar 

  • Coppleson M, Reid B (1967) Preclinical carcinoma of the cervix uteri. Pergamon, Oxford

    Google Scholar 

  • Creasman WT, Fetter BF, Clarke-Pearson DL et al. (1985) Management of stage IA carcinoma of the cervix. Am J Obstet Gynecol 153: 164–172

    PubMed  CAS  Google Scholar 

  • Fettig O (1964) Zur morphologischen und klinischen Problematik des Makrocarzinoms (Kollum Carzinom Stadium Ia). Arch Gynäkologie 199: 571–608

    Article  CAS  Google Scholar 

  • Fidler HK, Boyes DA, Worth AI (1968) Cervical cancer detection in British Columbia. J Obstet Gynaecol Br Commonw 75: 392–404

    Article  PubMed  CAS  Google Scholar 

  • FIGO Cancer Committee (1986) Staging announcement. Gynecol Oncol 25: 383–385

    Article  Google Scholar 

  • Fox CH (1967) Biologic behaviour of dysplasia and carcinoma in situ. Am J Obstet Gynecol 99: 960–974

    PubMed  CAS  Google Scholar 

  • Fu YS, Regan JW, Richart RM (1981) Definition of procursors. Gynecol Oncol 12: S220 - S223

    Article  PubMed  CAS  Google Scholar 

  • Galloway DA, McDougall JK (1985) The oncogenic potential of herpes simplex viruses: evidence for a `hit-and-run’ mechanism. Nature 302: 21–24

    Article  Google Scholar 

  • Galvin GA, Jones HW, Te Linde RW (1955) The significance of basal cell hyperactivity in cervical biopsies. Am J Obstet Gynecol 70: 808–821

    PubMed  CAS  Google Scholar 

  • Graham S, Priore R, Graham M, Browne R, Burnett W, West D (1979) Genital cancer in wives of penile cancer patients. Cancer 44: 1870–1874

    Article  PubMed  CAS  Google Scholar 

  • Green GH, Donovan JW (1970) The natural history of cervical carcinoma in situ. J Obstet Gynaecol Br Commonw 77: 1–9

    Article  PubMed  CAS  Google Scholar 

  • Hall JE, Walton L (1968) Dysplasia of the cervix: a prospective study of 206 cases. Am J Obstet Gynecol 100: 662–671

    PubMed  CAS  Google Scholar 

  • Hamperl H (1959) Definition and classification of the so-called carcinoma in situ. Symposion Ciba Foundation study group No.3, “cancer of the cervix”, S. 2. Churchill, London.

    Google Scholar 

  • Harris RWC, Brinton LA, Cowdell RH et al. (1980) Characteristics of women with dysplasia or carcinoma in situ of the cervix uteri. Br J Cancer 42: 359–369

    Article  PubMed  CAS  Google Scholar 

  • Herrero R, Brinton LA, Reeves WC et al. (1990) Sexual behavior, venereal diseases, hygiene practice, and invasive cervical cancer in a high-risk population. Cancer 65: 380–386

    Article  PubMed  CAS  Google Scholar 

  • Holzer E (1982) Microinvasive carcinoma of the cervix: clinical aspects, treatment and follow-up. Clin Oncol 1: 315–322

    Google Scholar 

  • Ikeda M, Inoue T, Noda K (1988) On the new FIGO classification of the stage la of uterine cervix (in Japanese). Obstet Gynecol 55: 1647–1651

    Google Scholar 

  • International Committee on Histological Definition (1961) Acta Cytol 6: 235–236

    Google Scholar 

  • Ismail SM, Colclough AB, Dinnen JKS et al. (1989) Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia. Br Med J 298: 707–710

    Article  CAS  Google Scholar 

  • Iwasaka T, Yokoyama M, Hayashi Yet al. (1988) Combined herpes simplex virus type 2 and human pap. virus 16 or 18 leads to oncogenic transformation. Am J Obstet Gynecol 159: 1251–1255

    PubMed  CAS  Google Scholar 

  • Johnson LD, Nickerson RJ, Easterday CL, Stuart RS, Hertig AT (1968) Epidemiological evidence for the spectrum of change from dysplasia through carcinoma in situ to invasive cancer. Cancer 22: 901–914

    Article  PubMed  CAS  Google Scholar 

  • Jordan JA, Sharp F, Singer A (eds) (1982) Proceedings of the Ninth Study Group of the Royal College of Obstetricians and Gynaecologists. Royal College of Obstetricians and Gynaecologists, London, pp 299–300

    Google Scholar 

  • Josey WE, Nahmias Al, Naib ZM (1972) The epidemiology of type 2 (genital) herpes simplex virus infection. Obstet Gynecol Sury 27: 295–302

    Google Scholar 

  • Kinlen Li, Spriggs Al (1978) Women with positive cervical smears but without surgical intervention. Lancet 11: 463–465

    Article  Google Scholar 

  • Kirkland JA, Stanley MA, Cellier KM (1967) Comparative study of histologic and chromosomal abnormalities in cervical neoplasia. Cancer 20: 1934–1952

    Article  PubMed  CAS  Google Scholar 

  • Kolstad P, Abeler V, Iversen T, Kjorstad K (1982) Microinvasive carcinoma of the cervix: definition and treatment problems. Clin Oncol 1: 335–347

    Google Scholar 

  • Kurihara S (1975) On the stage la cancer of the uterine cervix (in Japanese). World Obstet Gynecol 27: 707–712

    Google Scholar 

  • Lohe KJ (1978) Early squamous cell carcinoma of the uterine cervix. 1. Definition and histology. Gynecol Oncol 6: 10–30

    Article  PubMed  CAS  Google Scholar 

  • McKenna JM, Davis FE (1966) Induction of neoantigen ( G) in human amnion (“WISH”) cells by herpes virus A. Nature 212: 1602–1603

    Google Scholar 

  • Melnick JL, Adam E, Rawls WE (1974) The causative role of herpes virus type II in cervical cancer. Cancer 34: 1375–1385

    Article  PubMed  Google Scholar 

  • Mestwerdt G (1947) Die Frühdiagnose des Kollumkarzinoms, Zbl. Gynäkologie 69: 198–203

    Google Scholar 

  • Moore JG (1961) Management of early carcinoma. Am J Obstet Gynecol 85: 1175–1182

    Google Scholar 

  • Nahmias AJ, Naib AM, Highsmith AK, Josey WE (1967) Experimental genital herpes simplex infection in the mouse. Pediatr Res 1: 209

    Article  Google Scholar 

  • Naib ZM, Nahmias AJ, Josey WE (1966) Cytology and histopathology of cervical herpes simplex infection. Cancer 19: 1026–1031

    Article  PubMed  CAS  Google Scholar 

  • Naib ZM, Nahmias AJ, Josey WE, Kramer JH (1969) Genital herpetic infection association with cervical dysplasia and carcinoma. Cancer 23: 940–945

    Article  PubMed  CAS  Google Scholar 

  • Nasiell K, Nasiell M, Vaclavinkova V (1983) Behavior of moderate cervical dysplasia during long-term follow-up. Obstet Gynecol 61: 609–614

    PubMed  CAS  Google Scholar 

  • National Cancer Institute Workshop (1989) The Bethesda system for reporting cervical/vaginal cytologic diagnosis. Acta Cytol 33: 567–574

    Google Scholar 

  • Noda K (1975) Diagnosis and treatment of la cancer of the cervix (in Japanese). Obstet Gynecol Ther 30: 268–272

    Google Scholar 

  • Noda K (1979) Dysplasia of the cervix. Gynecology and obstetrics. Proceedings of the I X World Congress of Gynecology and Obstetrics. Excerpta Medica, Tokyo

    Google Scholar 

  • Noda K, Yajima A, Higashiiwai H, Sato A, Teshima K (1976) Histopathologic criterion of dysplasia of the cervix and its biological nature. Acta Cytol 20: 224–228

    PubMed  CAS  Google Scholar 

  • Noda K, Taki I, Takeuchi S et al. (1979) A new proposal regarding criteria for stage la cancer in the uterine cervix, Gynecol Oncol 8: 353–369

    Article  Google Scholar 

  • Nuovo GJ, Cottral S, Richart RM (1989) Occult human papillomavirus infection of the uterine cervix in postmenopausal women. Am J Obstet Gynecol 160: 340–344

    PubMed  CAS  Google Scholar 

  • Ory HW, Jenkins RJ, Byrd JY, Nahmias AJ, Tyler CW Jr, Allen DT, Conger SB (1975) The epidemiology and interrelationship of cervical dysplasia and type 2 herpesvirus in a low-income housing project. Am J Obstet Gynecol 123: 269–274

    PubMed  CAS  Google Scholar 

  • Park IJ, Jones HW (1968) Glucose-6-phosphate dehydrogenase and the histogenesis of epidermoid carcinoma of the cervix. Am J Obstet Gynecol 102: 106–109

    PubMed  CAS  Google Scholar 

  • Poulsen HE, Taylor CW, Sobin LH (1975) Histological typing of female genital tract tumors. International histological classification of tumors, No. 13. World Health Organization, Geneva

    Google Scholar 

  • Prendiville W, Guillebaud J, Bamford P, Beilby J, Steel SJ (1980) Carcinoma of the cervix with recent normal Papanicolaou tests. Lancet 11: 835–854

    Google Scholar 

  • Rawls WE, Laurel D, Melnick JL, Glicksman JM, Kaufman RH (1968) A search for viruses in smegma, premalignant and early malignant cervical tissues. The isolation of herpesviruses with distinct antigenic properties. Am J Epidemiol 87: 647–655

    Google Scholar 

  • Rawls WE, Tompkins WAF, Melnick JL (1969) The association of herpesvirus type 2 and carcinoma of the uterine cervix. Am J Epidemiol 89: 547–554

    PubMed  CAS  Google Scholar 

  • Reagan JW, Hamonic MJ (1956) Dysplasia of the uterine cervix. Ann NY Acad Sci 63: 12361244

    Google Scholar 

  • Reagan JW, Seidemand IL, Saracusa Y (1953) The cellular morphology of carcinoma in situ and dysplasia or atypical hyperplasia of the uterine cervix. Cancer 6: 224–235

    Article  PubMed  CAS  Google Scholar 

  • Reid R, Fu YS, Herschman BR et al. (1984) Genital warts and cervical cancer. Am J Obstet Gynecol 150: 189–199

    PubMed  CAS  Google Scholar 

  • Richart RM (1963) A radioautographic analysis of cellular proliferation in dysplasia and carcinoma in situ of the uterine cervix. Am J Obstet Gynecol 86: 925–930

    PubMed  CAS  Google Scholar 

  • Richart RM (1967) Natural history of cervical intraepithelial neoplasia. Clin Obstet Gynecol 10: 748–784

    Article  Google Scholar 

  • Richart RM (1976) Cervical intraepithelial neoplasia and the cervicologist.. Can J Med Technol 38: 177

    Google Scholar 

  • Richart RM (1990) A modified terminology for cervical intraepithelial neoplasia. Obstet Gynecol 75: 131–132

    PubMed  CAS  Google Scholar 

  • Richart RM, Barron BA (1969) A follow-up study of patients with cervical dysplasia. Am J Obstet Gynecol 105: 386–393

    PubMed  CAS  Google Scholar 

  • Richart RM, Crum CP (1982) The role of infective agents in the genesis of cervical intraepithelial neoplasia. In: Anderson MC (ed) Proceedings of the fourth world congress for cervical pathology and colposcopy. Churchill Livingstone, London

    Google Scholar 

  • Richart RM, Lerch V, Barron BA (1967) A time-lapse cinematographic study in vitro of mitoses in normal human cervical epithelium, dysplasia and carcinoma in situ. JNCI 39: 571–577

    PubMed  CAS  Google Scholar 

  • Roche WD, Norris Hi (1975) Microinvasive carcinoma of the cervix. The significance of lymphatic invasion and confluent patterns of stromal growth. Cancer 36: 180–186

    Google Scholar 

  • Royston I, Aurelian L (1970) The association of genital herpesvirus with cervical atypia and carcinoma in situ. Am J Epidemiol 91: 531–538

    PubMed  CAS  Google Scholar 

  • Shingleton HM, Richard RM, Wiener J, Spiro D (1968) Human cervical intraepithelial neoplasia: fine structure of dysplasia and carcinoma in situ. Cancer Res 28: 695–706

    PubMed  CAS  Google Scholar 

  • Simon NL, Gore H, Shingleton HM, Soong SJ, Orr JW, Hatch KD (1986) Study of superficially invasive carcinoma of the cervix. Obstet Gynecol 68: 19–24

    PubMed  CAS  Google Scholar 

  • Smith JW, Townsend DE, Sparkes RS (1971) Genetic variants of glucose-6-phosphate dehydrogenese in the study of carcinoma of the cervix. Cancer 28: 529–532

    Article  PubMed  CAS  Google Scholar 

  • Spriggs AI, Bowey CE, Cowdell H (1971) Chromosomes of precancerous lesions of the cervix uteri. Cancer 27: 1239–1254

    Article  PubMed  CAS  Google Scholar 

  • Taki I (1979) The report of the Cancer Committee of the Japan Society of Obstetrics and Gynecology (in Japanese). Acta Obstet Gynaecol Jpn 30: 1755–1756

    Google Scholar 

  • Tanaka S, Southam CM (1965) Joint action of herpes simplex virus and 3-methylcholanthrene in production of papillomas in mice. JNCI 34: 441–451

    PubMed  CAS  Google Scholar 

  • Tsukamoto N, Kaku T, Matsukuma K, Matsuyama T, Kamura T, Saito T, Suenaga T (1989) The problem of stage la (FIGO 1985) carcinoma of the uterine cervix. Gynecol Oncol 34: 1–6

    Article  PubMed  CAS  Google Scholar 

  • van Nagell JR, Greenwell N, Powell DF, Donaldson ES, Hanson MB, Gay EC (1983) Microinvasive carcinoma of the cervix. Am J Obstet Gynecol 145: 981–991

    PubMed  Google Scholar 

  • Wigle DT, Mao Y, Grace M (1980) Re: `Smoking and cancer of the uterine cervix: hypothesis’ (letter). Am J Epidemiol 111: 125–127

    PubMed  CAS  Google Scholar 

  • Willbanks GD, Richart RM, Terner JY (1967) DNA content of cervical intraepithelial neoplasia studied by two-wave length Feulgen cytophotometry. Am J Obstet Gynecol 98: 792–799

    Google Scholar 

  • Willett GD, Kurman RJ, Reid R, Greenberg M, Jenson AB, Lorincz AT (1989) Correlation of the histologic appearance of intraepithelial neopolasia of the cervix with human papillomavirus types. Emphasis on low-grade lesions including so-called flat condyloma. Int J Gynecol Pathol 8: 18–25

    Google Scholar 

  • Winkelstein W (1986) Cigarette smoking and cancer of the uterine cervix. Banbury Report 23: 329–341

    Google Scholar 

  • Winkelstein W Jr (1977) Smoking and cancer of the uterine cervix: hypothesis. Am J Epidemiol 106: 257–259

    PubMed  Google Scholar 

  • Woodworth CD, Bowden PE, Doniger J, Pirisi L, Barnes W, Lancaster WD, DiPaolo JA (1988) Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus types 16 and 18 DNA. Cancer Res 48: 4620–4628

    PubMed  CAS  Google Scholar 

  • World Health Organization/International Agency for Research on Cancer (1986) Epidemiological studies of cancer in humans. In: IARC monograph on the evaluation of the carcinogenic risk of chemicals to humans: tobacco smoking. International Agency for Research on Cancer, Lyon, pp 199–308

    Google Scholar 

  • Yajima H, Noda T, de Villiers EM, Yajima A, Yamamoto K, Noda K, Ito Y (1988) Isolation of a new type of human papillomavirus (HPV52b) with a transforming activity from cervical cancer tissue. Cancer Res 48: 7164–7172

    CAS  Google Scholar 

  • Yamabe T (1974) Histological criteria of la cancer of the cervix (in Japanese). Acta Obstet Gynaecol Jpn 26: 641–644

    Google Scholar 

  • Zur Hausen H (1982) Human genital cancer: synergism between two virus infections or synergism between a virus infection and an initiating agent. Lancet 11: 1370–1372

    Article  Google Scholar 

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  1. K. Noda
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Editors and Affiliations

  1. Tohoku University School of Medicine, 3-6-12 Kuromatsu, Izumi-Ku, Sendai 981, Japan

    Nobuaki Sasano MD (Professor Emeritus) (Professor Emeritus)

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Noda, K. (1992). Cervical Intraepithelial Neoplasia and Microinvasive Carcinoma of the Cervix. In: Sasano, N. (eds) Gynecological Tumors. Current Topics in Pathology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75941-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-75941-3_3

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