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Oncogenes in Gynecological Tumors

  • Chapter
Gynecological Tumors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 85))

Abstract

Recent scientific and technical advances in molecular biology have provided a new understanding of the basis of various diseases, especially malignant neoplasms. These techniques and knowledge are not only tools of medical research but are becoming increasingly utilized in the fields of clinical medicine, including both anatomic and clinical pathology.

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References

  • Baker SJ, Fearon ER, Nigro JM, et al. (1989) Chromosome 17 deletions and p53 gene mutations in colorectal carcinoma. Science 244: 217–221

    Article  PubMed  CAS  Google Scholar 

  • Baker VV, Hatch KD, Shingleton HM (1988) Amplification of c-myc proto-oncogene in cervical carcinoma. J Surg Oncol 39: 225–228

    Article  PubMed  CAS  Google Scholar 

  • Berchuck A, Kamel A, Whitaker R, Kerns B, Olt G, Kinney R, Soper JT, Dodge R, Clarke-Pearson

    Google Scholar 

  • DL, Marks P, McKenzie S, Yin S, Bast RC Jr (1990) Overexpression of HER-2/nev is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 50: 4087–4091

    PubMed  Google Scholar 

  • Black MM, Spear FD (1957) Nuclear structure in cancer tissues. Surg Gynecol Obstet 105: 97–102

    PubMed  CAS  Google Scholar 

  • Blumenfeld D, Braly PS, Ben-Ezra J, Klevecz RR (1987) Tumor DNA content as a prognostic feature in advanced epithelial carcinoma. Gynecol Oncol 27: 389–398

    Article  PubMed  CAS  Google Scholar 

  • Boltz EM, Kefford RF, Leary JA, Houghton CR, Friendlander ML (1989) Amplification of c-ras-ki oncogene in human ovarian tumors. Int J Cancer 43: 423–430

    Article  Google Scholar 

  • Brodeur GM (1987) The involvement of oncogenes and suppressor genes in human neoplasia. Adv Pediatr 34: 1–44

    PubMed  CAS  Google Scholar 

  • Buck KB, Liu ET, Larrick JW (1988) Oncogenes. Springer, New York Heidelberg Berlin

    Google Scholar 

  • DiLuca D, Costa S, Monini P et al. (1989) Search for human papilloma virus, herpes simplex virus and c-myc oncogene in human genital tumors. Int J Cancer•43: 570–577

    Google Scholar 

  • Durst M, Croce CM, Grissman L, Schwartz E, Huebner K (1987) Papilloma virus sequences integrate near cellular oncogenes in some cervical carcinomas. Proc Natl Acad Sci USA 84: 1070–1074

    Article  PubMed  CAS  Google Scholar 

  • Dyson N, Howley PM, Munger K, Harlow E (1989) The human papilloma virus-16E7 oncoprotein is able to bind to the retinoblastoma gene product. Scinece 243: 934–940

    Article  CAS  Google Scholar 

  • Ehlen T, Dubeau L (1990) Loss of heterozygosity on chromosomal segments 3p, 6q, and 1 l in human ovarian carcinomas. Oncogene 5: 219–224

    PubMed  CAS  Google Scholar 

  • Freifelder D (1985) Essentials of molecular biology. Jones and Bartlett, Boston

    Google Scholar 

  • Friedlander ML, Russell P, Taylor IW, Hedley DW, Tattersail MHN (1984) Flow cytometric analysis of cellular DNA content as an adjunct to the diagnosis of ovarian tumors of borderline malignancy. Pathology 16: 301–306

    Article  PubMed  CAS  Google Scholar 

  • Friend SH, Bernard SR, Rogelj S, Weinberg RA, Rapaport JM, Albert DM, Dryja TP (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323: 643–646

    Article  PubMed  CAS  Google Scholar 

  • Fukumoto M, Estensen RD, Sha L et al. (1989) Association of ki-ras with amplified DNA sequences detected in human ovarian carcinomas by a modified in-gel renaturation assay. Cancer Res 49: 1693–1697

    PubMed  CAS  Google Scholar 

  • Fung Y-KT, Murphree AL, T’Ang A, Qian J, Hinrichs SH, Benedict W (1987) Structural evidence for the authenticity of the human retinoblastoma gene. Science 244: 217–221

    Google Scholar 

  • Garrett CT (1986) Oncogenes. Clin Chim Acta 156: 1–40

    Article  CAS  Google Scholar 

  • Haas M, Isakov J, Howell SB (1987) Evidence against ras activation in human ovarian carcinomas. Mol Biol Med 4: 265–275

    PubMed  CAS  Google Scholar 

  • Haluska FG, Tsujimoto Y, Croce CM (1987) Oncogene activation by chromosome translocation in human malignancy. Ann Rev Genet 21: 321–345

    Article  PubMed  CAS  Google Scholar 

  • Harbour JW, Lai S-L, Wang-Peng J, Gazdar AF, Minna JD, Kaye FJ (1988) Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241: 353–357

    Article  PubMed  CAS  Google Scholar 

  • Haseltine WA, Sodroski J, Patarca R, Briggs D, Perkins D, Wang-Staal F (1984) Structure of 3’ terminal region of type II human T lymphotrophic virus; evidence for a new coding region. Science 225: 419–421

    Article  PubMed  CAS  Google Scholar 

  • Hendrickson M, Ross J, Eifel P, Martinez A, Kempson R (1982) Uterine papillary serous carcinoma. A highly malignant form of endometrial carcinoma. Am J Surg Pathol 6: 93–108

    Google Scholar 

  • Hendy-Ibbs P, Cox H, Evan GI, Watson JV (1987) Flow cytometric quantitation of DNA and c-myc oncoprotein in archival biopsies of uterine cervix neoplasia. Br J Cancer 55: 275–282

    Article  PubMed  CAS  Google Scholar 

  • Hughes RA, Neill WA, Norval M (1989) Papilloma virus and c-myc antigen expression in normal and neoplastic cervical epithelium. J clin Pathol 42: 46–51

    Article  PubMed  CAS  Google Scholar 

  • Hunter T (1984) Oncogenes and proto-oncogenes: How do they differ? JNCI 73: 773–786

    PubMed  CAS  Google Scholar 

  • Kacinski BM, Carter D, Mittal K et al. (1988) High level expression of fms proto-oncogene mRNA is observed in clinically aggressive human endometrial adenocarcinoma. Int J Radiat Oncol Biol Phys 15: 823–829

    Article  PubMed  CAS  Google Scholar 

  • Kaczmare KL, Hyland JK, Watt R, Rosenburg M, Baserga R (1985) Microinjected c-myc as a competence factor. Science 228: 1313–1315

    Article  Google Scholar 

  • Klein G (1987) The approaching era of the tumor suppression genes. Science 2338: 1539–1545

    Article  Google Scholar 

  • Lauchlon SC (1968) Conceptual unity of the müllerian tumor group: a histological study. Cancer 22: 601–610

    Article  Google Scholar 

  • Lee EY-HP, To H, Shew J-Y, Bookstein R, Scully P, WH (1988) Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science 241: 218–221

    Article  PubMed  CAS  Google Scholar 

  • Lee JH, Kavanagh JJ, Wharton JT, Wildrick KDM, Blick M (1989) Allele loss at the c-Ha-rosi locus in human ovarian cancer. Cancer Res 49: 1220–1222

    PubMed  CAS  Google Scholar 

  • Lee W-H, Bookstein R, Hong F, Young L-J, Shew J-Y, Lee EY-H (1987) Human retinoblastoma susceptibility gene: cloning, identification and sequence. Science 235: 1394–1399

    Article  PubMed  CAS  Google Scholar 

  • Long CA, O’Brien TJ, Sanders MM, Bard DS, Quirk JG Jr (1988) A ras oncogene is expressed in adenocarcinoma of the endometrium. Am J Obstet Gynecol 159: 1512–1515

    PubMed  CAS  Google Scholar 

  • Lynch HT, Albano WA, Lynch JF, Lynch PM, Campbell A (1982) Surveillance and management of patients at high genetic risk for advanced ovarian carcinoma. Obstet Gynecol 59: 589–596

    PubMed  CAS  Google Scholar 

  • Machotka SV, Garrett CT, Schwartz AM, Callahan R (1989) Amplification of the proto-oncogenes int-2, c-erbB-2 and c-myc in human breast cancer. Clin Chim Acta 184: 207–218

    Article  PubMed  CAS  Google Scholar 

  • Masuda H, Battifora H, Yokota J, Meltzer S, Cline MJ (1987) Specificity of proto-oncogene amplification in human malignant diseases. Mol Biol Med 4: 213–227

    PubMed  CAS  Google Scholar 

  • Merkel DE, Mcguire WL (1988) Oncogenes and cancer prognosis. In: Davis VT Jr, Hellman S, Rosenberg SA (eds) Important advances in oncology. J.B. Lippincott, Philadelphia, pp 103–117

    Google Scholar 

  • Ocadiz R, Sauceda R, Cruz M, Graef AM, Gariglio P (1987) High correlation between alterations of c-myc oncogene and carcinoma of the uterine cervix. Cancer Res 47: 4173–4177

    PubMed  CAS  Google Scholar 

  • Polacarz SV, Hey NA, Stephenson TJ, Hill AS (1989) c-myc oncogene product p62°-my` in ovarian mucinous neoplasms: immunohistochemical study correlated with malignancy. J Clin Pathol 42: 148–152

    Google Scholar 

  • Riou G, Barrois M, Le MG, George M, Le Doussal V, Haie C (1987) c-myc protooncogene expression and prognosis in early carcinoma of the uterine cervix. Lancet I (8536) 761–763

    Google Scholar 

  • Riou G, Barrois M, Sheng ZM, Duvillard P, Lhomme C (1988) Somatic deletion and mutations of c-Ha-ras gene in human cervical cancers. Oncogene 3: 329–333

    PubMed  CAS  Google Scholar 

  • Rodenburg CJ, Koelma IA, Nap M, Fleuren GJ (1988) Immunohistochemical detection of the ras oncogene product p21 in advanced ovarian cancer. Arch Pathol Lab Med 912: 151–154

    Google Scholar 

  • Sagae S, Kuzumaki N, Hisada T, Mugikura Y, Kudo R, Hashimoto M (1989) Ras oncogene expression and prognosis of invasive squamous carcinoma of the uterine cervix. Cancer 63: 1577–1582

    Google Scholar 

  • Sager R (1986) Genetic suppression of tumor formation: a new frontier in cancer research. Cancer Res 46: 1573–1580

    PubMed  CAS  Google Scholar 

  • Sager R (1989) Tumor suppressor genes: the puzzle and the promise. Science 246: 1406–1412

    Article  PubMed  CAS  Google Scholar 

  • Sasano H, Comerford J, Silverberg SG, Garrett CT (1990a) Analysis of abnormalities of the retinoblastoma gene in human ovarian and endometrial carcinoma. Cancer 66: 2150–2154

    Article  PubMed  CAS  Google Scholar 

  • Sasano H, Carrett CT, Wilkinson DS, Silverberg SG, Comerford J, Hyde J (1980b) Protooncogene amplification and tumor ploidy in human ovarian neoplasms. Hum Pathol 21: 382–391

    Article  Google Scholar 

  • Sasano H, Comerford J, Wilkinson DS, Schwartz A, Garrett GT (1990c) Serous papillary adenocar-cinoma of the endometrium: protooncogene amplification, flow cytometry, estrogen and proges-terone recepros and immunohistochemical analysis. Cancer 65: 1545–1551

    Article  PubMed  CAS  Google Scholar 

  • Silverberg SG (1989) Prognostic significance of pathologic features in ovarian carcinoma. Curr Top Pathol 78: 85–109

    Article  PubMed  CAS  Google Scholar 

  • Slamon DJ, de Kernion JB, Verma IM, Cline MJ (1984) Expression of cellular oncogenes in human malignancy. Science 224: 256–262

    CAS  Google Scholar 

  • Slamon DJ, Godolphin W, Jones LA et al. (1989) Studies of the HER-2/neu protooncogene in human breast and ovarian cancer. Science 244: 707–712

    Article  PubMed  CAS  Google Scholar 

  • Stanbridge EJ (1988) Genetic analysis of human malignancy using somatic cell hybrids and monochromosome transfer. Cancer Sury 7: 317–324

    CAS  Google Scholar 

  • van’t Veer LJ, Hermens R, van der Bakker LAM et al. (1988) ras oncogene activation in human ovarian carcinoma. Oncogene 2: 157–165

    Google Scholar 

  • Vogelstein B, Fearon ER, Hamilton SR et al. (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319: 525–532

    Article  PubMed  CAS  Google Scholar 

  • Vogelstein B, Fearon ER, Kern SE, Hamilton SR, Presinger AC, Nakamura Y, White R (1989) Allotype of colorectal carcinomas. Science 244: 207–211

    Article  PubMed  CAS  Google Scholar 

  • Watson JV, Curling OM, Munn CF, Hudson CN (1987) Oncogene expression in ovarian cancer: a pilot study of c-myc oncoprotein in serous papillary ovarian cancer. Gynecol Oncol 28: 137–150

    Article  PubMed  CAS  Google Scholar 

  • Williams CL, Fenoglio-Preiser CM (1987) Oncogenes, suppressor genes, and carcinogenesis. Hum Pathol 18: 895–902

    Article  Google Scholar 

  • Yavner D, Rice L, Weinberg D, Mendoza A, Lage J (1989) DNA analysis of borderline ( BL) ovarian tumors. Lab Invest 60: 107A

    Google Scholar 

  • Yoshida MA, Ohyashiki K, Piver SM, Sandberg AA (1986) Recurrent endometrial adenocarcinoma

    Google Scholar 

  • with rearrangement of chromosomes 1 and 11. Cancer Genet Gytogenet 20:218–220

    Google Scholar 

  • Yunis JJ, Boot AJM, Mayer MG, Bos JL (1989) Mechanism of ras mutation in myeolodysplastic syndrome. Oncogene 4: 609–614

    PubMed  CAS  Google Scholar 

  • Zang X, Silva E, Gershenson D, Hung M-C (1989) Amplification and rearrangement of c-erbproto-oncogenes in cancer of human female genital tract. Oncogene 4: 985–989

    Google Scholar 

  • Zhou DJ, Gonzalez-Cadavid N, Ahuva H, Battifora H, Moore GE, Cline MJ (1988) A unique pattern of proto-oncogene abnormalities in ovarian adenocarcinoma. Cancer 62: 1573–1576

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. H. Sasano
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  2. C. T. Garrett
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Editors and Affiliations

  1. Tohoku University School of Medicine, 3-6-12 Kuromatsu, Izumi-Ku, Sendai 981, Japan

    Nobuaki Sasano MD (Professor Emeritus) (Professor Emeritus)

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© 1992 Springer-Verlag Berlin Heidelberg

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Sasano, H., Garrett, C.T. (1992). Oncogenes in Gynecological Tumors. In: Sasano, N. (eds) Gynecological Tumors. Current Topics in Pathology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75941-3_12

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  • DOI: https://doi.org/10.1007/978-3-642-75941-3_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75943-7

  • Online ISBN: 978-3-642-75941-3

  • eBook Packages: Springer Book Archive

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