Abstract
As with knowledge of tumors of all tissues of the body, so our knowledge of endometrial tumors is in constant need of revision. On the one hand, such a revision represents the recognition of new tumor types, which usually arise because of changes in the environment, whereas other types of tumor become less common. On the other hand, progress in diagnostic methods has enabled us to define much of the fine structure and histogenesis of tumors. From these developments we are able to draw inferences about prognosis and therapy of the tumors. With the purpose of this book in mind, I restrict myself only to new advances in our knowledge of endometrial tumors made during the last 10 years, eschewing a comprehensive review of endometrial tumors in general.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aguirre P, Scully RE, Wolfe HJ, De Lellis RA (1984) Endometrial carcinoma with argyrophil cells: a histochemical and immunohistochemical analysis. Hum Pathol 15:210–217
Alberhasky RC, Connelly Pi, Christopherson WM (1982) Carcinoma of the endometrium. IV. Mixed adenosquamous carcinoma. A clinical-pathological study of 68 cases with long-term follow-up. Am J Clin Pathol 77:655–664
Aycock NR, Jollie WP, Dunn LJ (1979) An ultrastructural comparison of human endometrial adenocarcinoma with normal postmenopausal endometrium. Obstet Gynecol 53:565–571
Bannatyne P, Russell P, Wills EJ (1983) Argyrophilia and endometrial carcinoma. Int J Gynecol Pathol 2:235–254
Berchuck A, Soisson AP, Clarke-Pearson DL et al. (1989) Immunohistochemical expression of CA 125 in endometrial adenocarcinoma: correlation of antigen expression with metastatic potential. Cancer Res 49:2091–2095
Bersch W, Wolfmiiller H, Raufelder W (1984) Beitrag zur Ichthyosis uteri mit and ohne maligne Neoplasie. Pathologe 5:148–152
Bjersing L (1977) Endometrial hyperplasia and carcinoma: histopathology and hormonal factors. Acta Obstet Gynecol Scand 65:83–88
Bokhman JV (1983) Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 15:10–17
Burke TW, Heller PB, Woodward JE, Davidson SA, Hoskins WJ, Park RC (1990) Treatment failure in endometrial carcinoma. Obstet Gynecol 75:96–101
Chambers JT, Merino M, Kohorn ET et al. (1987) Uterine papillary serous carcinoma. Obstet Gynecol 69:109–113
Charles D (1965) Endometrial adenoacanthoma. Cancer 18:737–750
Charpin C, Martin PA, Lavaut MN et al. (1986) Estrogen receptor immunocytochemical assay (ER-ICA) in human endometrium. Int J Gynecol Pathol 5:119–131
Christopherson WM, Alberhasky RC, Connelly PJ (1982) Carcinoma of the endometrium: I. A clinicopathologic study of clear-cell carcinoma and secretory carcinoma. Cancer 49:1511–1523
Connelly PJ, Alberhasky RC, Christopherson WM (1982) Carcinoma of the endometrium. III. Analysis of 865 cases of adenocarcinoma and adenoacanthoma. Obstet Gynecol 59:569–575
Cowles TA, Magrina JF, Masterson BJ, Capen CV (1985) Comparison of clinical and surgical staging in patients with endometrial carcinoma. Obstet Gynecol 66:413–416
Creasmen WT (1990) Gradutate education. New gynecologic cancer staging. Obstet Gynecol 75:287–288
Czernobilsky B, Katz Z, Lancet M, Gaton E (1980) Endocervical-type epithelium in endometrial carcinoma. Am J Surg Pathol 4:481–489
Czernobilsky B, Moll R, Franke WW, Dallenbach-Hellweg G, Hohlweg-Majert P (1984) Intermediate filaments of normal and neoplastic tissues of the female genital tract with emphasis on problems of differential tumor diagnosis. Pathol Res Pract 179:31–37
Dabbs DJ, Geisinger KR, Norris HT (1986) Intermediate filaments in endocervical carcinomas: the diagnostic utility of vimentin patterns. Am J Surg Pathol 10:568–576
Dallenbach-Hellweg G (1984) On the origin and histological structure of adenocarcinoma of the endocervix in women under 50 years of age. Pathol Res Pract 179:38–50
Dallenbach-Hellweg G (1987) Histopathology of the endometrium. Springer, Berlin Heidelberg New York
Dallenbach-Hellweg G, Lang-Avérous G, Hahn U (1991) The value of immunohistochemistry in the differential diagnosis of endometrial carcinomas. APMISF 99:91–99
Dallenbach-Hellweg G, Lang G (1991) Immunohistochemical studies on uterine tumors: invasive adeno-carcinomas of the endocervix and their precursors. Pathol Res Pract 187:36–43
Dallenbach-Hellweg G, Weber J, Stoll P, Velten CH (1971) Zur Differentialdiagnose adenomatöser Endometriumhyperplasien junger Frauen. Arch Gynäkol 210:303–320
Dallenbach-Hellweg G, Dallenbach C, Lang G (1988) Zur Histogenese and Morphologie der Mukoepidermoiden Adenokarzinome des Corpusendometrium. Pathologe 9:351–357
Demopoulos RI, Dubin N, Noumoff J et al. (1986) Prognostic significance of squamous differentiation in stage 1 endometrial adenocarcinoma. Obstet Gynec 68:245–250
Eastwood J (1978) Mesonephroid (clear cell) carcinoma of the ovary and endometrium. A comparative prospective clinico-pathological study and review of literature. Cancer 41:1911–1928
Ehrlich CE, Young PCM, Cleary RE (1981) Cytoplasmic progesterone and estradiol receptors in normal, hyperplastic, and carcinomatous endometria: therapeutic implications. Am J Obstet Gynecol 141:539–546
Eifel P, Hendrickson M, Ross J et al. (1982) Simulataneous presentation of carcinoma involving the ovary and the uterine corpus. Cancer 50:163–170
Fanning J, Erang MC, Peters AJ, Samuel M, Harmon ER, Bates JS (1989) Endometrial adenocarcinoma histologic subtypes: clinical and pathologic profile. Gynecol Oncol 32:288–291
Fechner RE, Kaufman RH (1974) Endometrial adenocarcinoma in Stein–Leventhal syndrome. Cancer 34:444–452
Fornander T, Cedermark B, Mattsson A et al. (1989) Adjuvant tamoxifen in early breast cancer: occurrence of new primary cancers., Lancet I:117–120
Frauenhoffer EF, Zaino RJ, Wolff TV, Whitney CH (1987) Value of Endocervical curettage in the staging of endometrial carcinoma. Int J Gynecol Pathol 6:195–202
Fu YS, Parks PJ, Reagen JW, Wentz WB, Storaasli JP (1979) The ultrastructure and factors relating to survival of endometrial cancers. Am J Diag Gynecol Obstet 1:55–56
Hachisuga T (1986) Endometrial carcinoma. A histopathologic analysis of 155 cases with special reference to prognostic factors and background lesions. Fukuoka Igaku Zasshi 77:314–332
Hendrickson MR, Kempson RL (1980a) The differential diagnosis of endometrial adenocarcinoma. Some viewpoints concerning a diagnostic problem. Pathology 32:35–61
Hendrickson MR, Kempson RL (1980b) Endometrial epithelial metaplasias—proliferations frequently misdiagnosed as adenocarcinoma: report of 89 cases and proposed classification. Am J Surg Pathol 4:525–542
Hendrickson MR, Ross J, Eifel P et al. (1982) Uterine papillary serous carcinoma. Am J Surg Pathol 6:93–108
Hertig AT, Gore H (1960) Tumors of the female sex organs, part 2. In: Atlas of tumor pathology, Sect. IX, fasc. 33. Armed Forces Institute of Pathology, Washington DC
Horie A, Yasumoto K, Ueda H et al. (1977) Clear cell adenocarcinoma of the uterus—ultrastructural and hormonal study. Acta Pathol Jpn 27:907–915
Hustin J (1975) Effect of protein hormones and steroids on tissue cultures of endometrial carcinoma. Br J Obstet Gynaecol 82:493–500
Kanbour A, Stock J (1978) Squamous cell carcinoma in situ of the endometrium and fallopian tube as superficial extension of invasive cervical carcinoma. Cancer 42:570–580
Killakey MA, Hakes TB, Pierce VK (1985) Endometrial adenocarcinoma in breast cancer patients receiving antiestrogens. Cancer Treat Rep 69:237–238
Kumar NB, Hart WR (1982) Metastases to the uterine corpus from extragenital cancers—a clinico-pathologic study of 63 cases. Cancer 50:2163–2169
Kurman RJ, Norris HJ (1982) Evaluation of criteria for distinguishing atypical endometrial hyperplasia from well-differentiated carcinoma. Cancer 49:2547–2559
Kurman RJ, Norris HJ (1987) Endometrial carcinoma. In: Kurman RJ (ed) Blaustein’s pathology of the female genital tract. Springer, New York Berlin Heidelberg
Kurman RJ, Scully RE (1976) Clear cell carcinoma of the endometrium. An analysis of 21 cases. Cancer 37:872–882
Kurman RJ, Kaminski PF, Norris HJ (1985) The behavior of endometrial hyperplasia. A long-term study of “untreated” hyperplasia in 170 patients. Cancer 56:403–412
Lang G, Lang M, Dallenbach-Hellweg G (1989) Immunhistochemische Rezeptorbefunde im Endometrium and therapeutische Konsequenzen bei endogenen and exogenen Funktionsstörungen and im Karzinom. Geburtshilfe Frauenheilkd 49:1025–1100
Lee KR, Scully RE (1989) Complex endometrial hyperplasia and carcinoma in adolescents and young women 15 to 20 years of age: a report of 10 cases. Int J Gynecol Pathol 8:201–219
Liu CT (1972) A study of endometrial adenocarcinoma with emphasis on morphologically variant types. Am J Clin Pathol 57:562–573
Maes G, Fleuren GJ, Bara J, Nap M (1988) The distribution of mucins, carcinoembryonic antigen, and mucus-associated antigens in endocervical and endometrial adenocarcinomas. Int J Gynecol Pathol 7:112–122
McNutt MA, Bolen JW, Gown AM et al. (1985) Coexpression of intermediate filaments in human epithelial neoplasms. Ultrastruct Pathol 9:31–43
Melhem MF, Tobon H (1987) Mucinous adeno-carcinoma of the endometrium: a clinico-pathological review of 18 cases. Int J Gynecol Pathol 6:347–355
Melin JR, Wanner L, Schulz DM, Cassel EE (1979) Primary squamous cell carcinoma of the endometrium. Obstet Gynecol 53:115–119
Mittal KR, Schwartz PE, Barwick KW (1988) Architectural (FIGO) grading, Nuclear grading, and other prognostic indicators in stage I endometrial adenocarcinoma with identification of high-risk and low-risk groups. Cancer 61:538–545
Moll R, Levy R, Czernobilsky B et al. (1983) Cytokeratins of normal epithelia and some neoplasms of the female genital tract. Lab Invest 49:559–609
Moukhtar M, Aleem FA, Hung HC et al. (1977) The reversible behavior of locally invasive endometrial carcinoma in a chromosomally mosaic (45, X/46, Xr (X)) young woman treated with Clomid. Cancer 40:2957–2966
Mutch DG, Soper JT, Budwit-Novotny DA et al. (1987) Endometrial adenocarcinoma estrogen receptor content: association of clinicopathologic features with immunohistochemical analysis compared with standard biochemical methods. Am J Obstet Gynecol 157:924–931
Ng ABP, Reagan JW (1970) Incidence and prognosis of endometrial carcinoma by histologic grade and extent. Obstet Gynecol 35:437–443
Nordqvist S (1970) The synthesis of DNA and RNA in human carcinomatous endometrium in short-term incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 48:29–38
Norris HJ, Tavassoli FA, Kurman RJ (1983) Endometrial hyperplasia and carcinoma. Am J Surg Pathol 7:839–847
Nuovo MA, Nuovo GJ, McCaffrey M et al. (1989) Endometrial polyps in postmenopausal patients receiving tamoxifen. Int J Gynecol Pathol 8:125–131
Olson N, Twiggs L, Sibley R (1982) Small-cell carcinoma of the endometrium: light microscopic and ultrastructural study of a case. Cancer 50:760–765
Pertschuk LP, Beddoe AM, Gorelic LS, Shain SA (1986) Immunocytochemical assay of estrogen receptors in endometrial carcinoma with monoclonal antibodies. Cancer 57:1000–1004
Piver MS, Barlow JJ, Lurrain JR, Blumenson LE (1980) Medroxyprogesterone acetate (Depo-Provera) vs hydroxyprogesterone caproate (Delalutin) in women with metastatic endometrial adenocarcinoma. Cancer 45:268–272
Puts JJG, Moesker O, Aldeweireldt J (1987) Application of antibodies to intermediate filament proteins in simple and complex tumors of the female genital tract. Int J Gyn Pathol 6:257–274
Robboy SJ, Bradley R (1979) Changing trends and prognostic features in endometrial cancer associated with exogenous estrogen therapy. Obstet Gynecol 54:269–277
Rodriquez J, Sen KK, Seski JC et al. (1979) Progesterone binding by human endometrial tissue during the proliferative and secretory phases of menstrual cycle and by hyperplastic and carcinomatous endometrium. Am J Obstet Gynecol 133:660–665
Ross JC, Eifel PJ, Cox RS et al. (1983) Primary mucinous adenocarcinoma of the endometrium. Am J Surg Pathol 7:715–729
Sasano H, Comerfor J, Wilkinson DS et al. (1990) Serous papillary adenocarcinoma of the endometrium. Cancer 65:1545–1551
Sato N, Mori T, Orenstein JM, Silverberg SG (1984) Ultrastructure of papillary serous carcinoma of the endometrium. Int J Gynecol Pathol 2:337–348
Scully RE, Aguirre P, De Lellis RA (1984) Argyrophilla, serotonin, and peptide hormones in the female genital tract and its tumors. Int J Gynecol Pathol 3:51–70
Segreti EM, Novotny DB, Soper JT et al. (1989) Endometrial cancer: histologic correlates of immunohistochemical localization of progesterone receptor and estrogen receptor. Obstet Gynecol 73:780–785
Simon A, Kopolovic J, Beyth Y (1988) Primary squamous cell carcinoma of the endometrium. Gynecol Oncol 31:454–461
Simon WE, Hölzel F (1979) Hormone sensitivity of gynecological tumor cells in tissue culture. J Cancer Res Clin Oncol 94:307–323
Sorvari TE (1969) A histochemical study of epithelial mucosubstances in endometrial and cervical adenocarcinomas with reference to normal endometrium and cervical mucosa. Acta Pathol Microbiol Scand [Suppl] 207:1–85
Tavassoli F, Kraus FT (1978) Endometrial lesions in uteri resected for atypical endometrial hyperplasia. Am J Clin Pathol 70:770–779
Thom MH, Davies KJ, Senkus RJ et al. (1981) Scanning electron microscopy of the endometrial cell surface in postmenopausal women receiving oestrogen therapy. Br J Obstet Gynaecol 88:904–913
Thrasher TV, Richart RM (1972) An ultrastructural comparison of endometrial adenocarcinoma and normal endometrium. Cancer 29:1713–1723
Tiltman AJ (1980) Mucinous carcinoma of the endometrium. Obstet Gynecol 55:244–245
Tubiana M (1971) The kinetics of tumour cell proliferation and radiotherapy. Br J Radiol 44:325–1000
Ueda G, Sato Y, Yamasaki M et al. (1977) Argyrophil cell adenocarcinoma of the endometrium. Acta Obstet Gynecol Jpn 29:1167–1168
Ueda S, Tsubura A, Izumi H et al. (1983) Immunohistochemical studies on carcinoembryonic antigen in adenocarcinomas of the uterus. Acta Pathol Jpn 33:59–69
Ueda G, Yamasaki M, Inoue M et al. (1986) Immonohistochemical demonstration of HNK-1-defined antigen in gynecologic tumors with argyrophilia. Int J Gynecol Pathol 5:143–150
Ulbright TM, Roth IM (1985) Metastatic and independent cancers of the endometrium and ovary:a clinico-pathologic study of 34 cases. Hum Pathol 16:28–34
Utaaker E, Iversen 0E, Skaarland E (1987) The distribution and prognostic implications of steroid receptors in endometrial carcinomas. Gynecol Oncol 28:89–100
Vihko R, Jänne O, Kauppila A (1980) Steroid receptors in normal, hyperplastic and malignant human endometria. Ann Clin Res 12:208–215
Wahlström T, Korhonen M, Lindgren J, Markku S (1979) Distinction between endocervical and endometrial adenocarcinoma with immunoperoxidase staining of carcinoembryonic antigen in routine histologic tissue sections. Lancet II:1159–1160
Walker AM, Jick H (1979) Cancer of the corpus uteri: increasing incidence in the United States. Am J Epidemiol 110:47–51
Walker AM, Jick H (1980) Declining rates of endometrial cancer. Obstet Gynecol 56:733–736
Weiner J, Bigelow B, Demopoulos RI et al. (1980) The value of endocervical sampling in the staging of endometrial carcinoma. Diagn Gynecol Obstet 2:265–268
Welch WR, Scully RE (1977) Precancerous lesions of the endometrium. Hum Pathol 8:503–512
Yamashina M, Kobara TY (1986) Primary squamous cell carcinoma with its spindle cell variant in the endometrium. Cancer 57:340–345
Young PCM, Ehrlich CE, Cleary RE (1976) Progesterone binding in human endometrial carcinomas. Am J Obstet Gynecol 125:353–360
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Dallenbach-Hellweg, G. (1992). Endometrial Carcinomas. In: Sasano, N. (eds) Gynecological Tumors. Current Topics in Pathology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75941-3_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-75941-3_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75943-7
Online ISBN: 978-3-642-75941-3
eBook Packages: Springer Book Archive