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Endometrial Carcinomas

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Gynecological Tumors

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 85))

Abstract

As with knowledge of tumors of all tissues of the body, so our knowledge of endometrial tumors is in constant need of revision. On the one hand, such a revision represents the recognition of new tumor types, which usually arise because of changes in the environment, whereas other types of tumor become less common. On the other hand, progress in diagnostic methods has enabled us to define much of the fine structure and histogenesis of tumors. From these developments we are able to draw inferences about prognosis and therapy of the tumors. With the purpose of this book in mind, I restrict myself only to new advances in our knowledge of endometrial tumors made during the last 10 years, eschewing a comprehensive review of endometrial tumors in general.

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References

  • Aguirre P, Scully RE, Wolfe HJ, De Lellis RA (1984) Endometrial carcinoma with argyrophil cells: a histochemical and immunohistochemical analysis. Hum Pathol 15:210–217

    Article  PubMed  CAS  Google Scholar 

  • Alberhasky RC, Connelly Pi, Christopherson WM (1982) Carcinoma of the endometrium. IV. Mixed adenosquamous carcinoma. A clinical-pathological study of 68 cases with long-term follow-up. Am J Clin Pathol 77:655–664

    PubMed  CAS  Google Scholar 

  • Aycock NR, Jollie WP, Dunn LJ (1979) An ultrastructural comparison of human endometrial adenocarcinoma with normal postmenopausal endometrium. Obstet Gynecol 53:565–571

    PubMed  CAS  Google Scholar 

  • Bannatyne P, Russell P, Wills EJ (1983) Argyrophilia and endometrial carcinoma. Int J Gynecol Pathol 2:235–254

    Article  PubMed  CAS  Google Scholar 

  • Berchuck A, Soisson AP, Clarke-Pearson DL et al. (1989) Immunohistochemical expression of CA 125 in endometrial adenocarcinoma: correlation of antigen expression with metastatic potential. Cancer Res 49:2091–2095

    PubMed  CAS  Google Scholar 

  • Bersch W, Wolfmiiller H, Raufelder W (1984) Beitrag zur Ichthyosis uteri mit and ohne maligne Neoplasie. Pathologe 5:148–152

    PubMed  CAS  Google Scholar 

  • Bjersing L (1977) Endometrial hyperplasia and carcinoma: histopathology and hormonal factors. Acta Obstet Gynecol Scand 65:83–88

    Article  CAS  Google Scholar 

  • Bokhman JV (1983) Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 15:10–17

    Article  PubMed  CAS  Google Scholar 

  • Burke TW, Heller PB, Woodward JE, Davidson SA, Hoskins WJ, Park RC (1990) Treatment failure in endometrial carcinoma. Obstet Gynecol 75:96–101

    PubMed  CAS  Google Scholar 

  • Chambers JT, Merino M, Kohorn ET et al. (1987) Uterine papillary serous carcinoma. Obstet Gynecol 69:109–113

    PubMed  CAS  Google Scholar 

  • Charles D (1965) Endometrial adenoacanthoma. Cancer 18:737–750

    Article  PubMed  CAS  Google Scholar 

  • Charpin C, Martin PA, Lavaut MN et al. (1986) Estrogen receptor immunocytochemical assay (ER-ICA) in human endometrium. Int J Gynecol Pathol 5:119–131

    PubMed  CAS  Google Scholar 

  • Christopherson WM, Alberhasky RC, Connelly PJ (1982) Carcinoma of the endometrium: I. A clinicopathologic study of clear-cell carcinoma and secretory carcinoma. Cancer 49:1511–1523

    Article  PubMed  CAS  Google Scholar 

  • Connelly PJ, Alberhasky RC, Christopherson WM (1982) Carcinoma of the endometrium. III. Analysis of 865 cases of adenocarcinoma and adenoacanthoma. Obstet Gynecol 59:569–575

    PubMed  CAS  Google Scholar 

  • Cowles TA, Magrina JF, Masterson BJ, Capen CV (1985) Comparison of clinical and surgical staging in patients with endometrial carcinoma. Obstet Gynecol 66:413–416

    PubMed  CAS  Google Scholar 

  • Creasmen WT (1990) Gradutate education. New gynecologic cancer staging. Obstet Gynecol 75:287–288

    Google Scholar 

  • Czernobilsky B, Katz Z, Lancet M, Gaton E (1980) Endocervical-type epithelium in endometrial carcinoma. Am J Surg Pathol 4:481–489

    Article  PubMed  CAS  Google Scholar 

  • Czernobilsky B, Moll R, Franke WW, Dallenbach-Hellweg G, Hohlweg-Majert P (1984) Interme­diate filaments of normal and neoplastic tissues of the female genital tract with emphasis on problems of differential tumor diagnosis. Pathol Res Pract 179:31–37

    Article  PubMed  CAS  Google Scholar 

  • Dabbs DJ, Geisinger KR, Norris HT (1986) Intermediate filaments in endocervical carcinomas: the diagnostic utility of vimentin patterns. Am J Surg Pathol 10:568–576

    Article  PubMed  CAS  Google Scholar 

  • Dallenbach-Hellweg G (1984) On the origin and histological structure of adenocarcinoma of the endocervix in women under 50 years of age. Pathol Res Pract 179:38–50

    Article  PubMed  CAS  Google Scholar 

  • Dallenbach-Hellweg G (1987) Histopathology of the endometrium. Springer, Berlin Heidelberg New York

    Book  Google Scholar 

  • Dallenbach-Hellweg G, Lang-Avérous G, Hahn U (1991) The value of immunohistochemistry in the differential diagnosis of endometrial carcinomas. APMISF 99:91–99

    Google Scholar 

  • Dallenbach-Hellweg G, Lang G (1991) Immunohistochemical studies on uterine tumors: invasive adeno-carcinomas of the endocervix and their precursors. Pathol Res Pract 187:36–43

    PubMed  CAS  Google Scholar 

  • Dallenbach-Hellweg G, Weber J, Stoll P, Velten CH (1971) Zur Differentialdiagnose adenomatöser Endometriumhyperplasien junger Frauen. Arch Gynäkol 210:303–320

    Article  PubMed  CAS  Google Scholar 

  • Dallenbach-Hellweg G, Dallenbach C, Lang G (1988) Zur Histogenese and Morphologie der Mukoepidermoiden Adenokarzinome des Corpusendometrium. Pathologe 9:351–357

    PubMed  CAS  Google Scholar 

  • Demopoulos RI, Dubin N, Noumoff J et al. (1986) Prognostic significance of squamous differentiation in stage 1 endometrial adenocarcinoma. Obstet Gynec 68:245–250

    PubMed  CAS  Google Scholar 

  • Eastwood J (1978) Mesonephroid (clear cell) carcinoma of the ovary and endometrium. A comparative prospective clinico-pathological study and review of literature. Cancer 41:1911–1928

    Article  PubMed  CAS  Google Scholar 

  • Ehrlich CE, Young PCM, Cleary RE (1981) Cytoplasmic progesterone and estradiol receptors in normal, hyperplastic, and carcinomatous endometria: therapeutic implications. Am J Obstet Gynecol 141:539–546

    PubMed  CAS  Google Scholar 

  • Eifel P, Hendrickson M, Ross J et al. (1982) Simulataneous presentation of carcinoma involving the ovary and the uterine corpus. Cancer 50:163–170

    Article  PubMed  CAS  Google Scholar 

  • Fanning J, Erang MC, Peters AJ, Samuel M, Harmon ER, Bates JS (1989) Endometrial adenocarcinoma histologic subtypes: clinical and pathologic profile. Gynecol Oncol 32:288–291

    Article  PubMed  CAS  Google Scholar 

  • Fechner RE, Kaufman RH (1974) Endometrial adenocarcinoma in Stein–Leventhal syndrome. Cancer 34:444–452

    Article  PubMed  CAS  Google Scholar 

  • Fornander T, Cedermark B, Mattsson A et al. (1989) Adjuvant tamoxifen in early breast cancer: occurrence of new primary cancers., Lancet I:117–120

    Article  Google Scholar 

  • Frauenhoffer EF, Zaino RJ, Wolff TV, Whitney CH (1987) Value of Endocervical curettage in the staging of endometrial carcinoma. Int J Gynecol Pathol 6:195–202

    Article  PubMed  CAS  Google Scholar 

  • Fu YS, Parks PJ, Reagen JW, Wentz WB, Storaasli JP (1979) The ultrastructure and factors relating to survival of endometrial cancers. Am J Diag Gynecol Obstet 1:55–56

    Google Scholar 

  • Hachisuga T (1986) Endometrial carcinoma. A histopathologic analysis of 155 cases with special reference to prognostic factors and background lesions. Fukuoka Igaku Zasshi 77:314–332

    PubMed  CAS  Google Scholar 

  • Hendrickson MR, Kempson RL (1980a) The differential diagnosis of endometrial adenocarcinoma. Some viewpoints concerning a diagnostic problem. Pathology 32:35–61

    Article  Google Scholar 

  • Hendrickson MR, Kempson RL (1980b) Endometrial epithelial metaplasias—proliferations frequently misdiagnosed as adenocarcinoma: report of 89 cases and proposed classification. Am J Surg Pathol 4:525–542

    Article  CAS  Google Scholar 

  • Hendrickson MR, Ross J, Eifel P et al. (1982) Uterine papillary serous carcinoma. Am J Surg Pathol 6:93–108

    Article  PubMed  CAS  Google Scholar 

  • Hertig AT, Gore H (1960) Tumors of the female sex organs, part 2. In: Atlas of tumor pathology, Sect. IX, fasc. 33. Armed Forces Institute of Pathology, Washington DC

    Google Scholar 

  • Horie A, Yasumoto K, Ueda H et al. (1977) Clear cell adenocarcinoma of the uterus—ultrastructural and hormonal study. Acta Pathol Jpn 27:907–915

    PubMed  CAS  Google Scholar 

  • Hustin J (1975) Effect of protein hormones and steroids on tissue cultures of endometrial carcinoma. Br J Obstet Gynaecol 82:493–500

    Article  PubMed  CAS  Google Scholar 

  • Kanbour A, Stock J (1978) Squamous cell carcinoma in situ of the endometrium and fallopian tube as superficial extension of invasive cervical carcinoma. Cancer 42:570–580

    Article  PubMed  CAS  Google Scholar 

  • Killakey MA, Hakes TB, Pierce VK (1985) Endometrial adenocarcinoma in breast cancer patients receiving antiestrogens. Cancer Treat Rep 69:237–238

    Google Scholar 

  • Kumar NB, Hart WR (1982) Metastases to the uterine corpus from extragenital cancers—a clinico-pathologic study of 63 cases. Cancer 50:2163–2169

    Article  PubMed  CAS  Google Scholar 

  • Kurman RJ, Norris HJ (1982) Evaluation of criteria for distinguishing atypical endometrial hyper­plasia from well-differentiated carcinoma. Cancer 49:2547–2559

    Article  PubMed  CAS  Google Scholar 

  • Kurman RJ, Norris HJ (1987) Endometrial carcinoma. In: Kurman RJ (ed) Blaustein’s pathology of the female genital tract. Springer, New York Berlin Heidelberg

    Google Scholar 

  • Kurman RJ, Scully RE (1976) Clear cell carcinoma of the endometrium. An analysis of 21 cases. Cancer 37:872–882

    Article  PubMed  CAS  Google Scholar 

  • Kurman RJ, Kaminski PF, Norris HJ (1985) The behavior of endometrial hyperplasia. A long-term study of “untreated” hyperplasia in 170 patients. Cancer 56:403–412

    Article  PubMed  CAS  Google Scholar 

  • Lang G, Lang M, Dallenbach-Hellweg G (1989) Immunhistochemische Rezeptorbefunde im Endometrium and therapeutische Konsequenzen bei endogenen and exogenen Funktionsstörungen and im Karzinom. Geburtshilfe Frauenheilkd 49:1025–1100

    Article  Google Scholar 

  • Lee KR, Scully RE (1989) Complex endometrial hyperplasia and carcinoma in adolescents and young women 15 to 20 years of age: a report of 10 cases. Int J Gynecol Pathol 8:201–219

    Article  PubMed  CAS  Google Scholar 

  • Liu CT (1972) A study of endometrial adenocarcinoma with emphasis on morphologically variant types. Am J Clin Pathol 57:562–573

    PubMed  CAS  Google Scholar 

  • Maes G, Fleuren GJ, Bara J, Nap M (1988) The distribution of mucins, carcinoembryonic antigen, and mucus-associated antigens in endocervical and endometrial adenocarcinomas. Int J Gynecol Pathol 7:112–122

    Article  PubMed  CAS  Google Scholar 

  • McNutt MA, Bolen JW, Gown AM et al. (1985) Coexpression of intermediate filaments in human epithelial neoplasms. Ultrastruct Pathol 9:31–43

    Article  PubMed  CAS  Google Scholar 

  • Melhem MF, Tobon H (1987) Mucinous adeno-carcinoma of the endometrium: a clinico-pathologi­cal review of 18 cases. Int J Gynecol Pathol 6:347–355

    Article  PubMed  CAS  Google Scholar 

  • Melin JR, Wanner L, Schulz DM, Cassel EE (1979) Primary squamous cell carcinoma of the endometrium. Obstet Gynecol 53:115–119

    PubMed  CAS  Google Scholar 

  • Mittal KR, Schwartz PE, Barwick KW (1988) Architectural (FIGO) grading, Nuclear grading, and other prognostic indicators in stage I endometrial adenocarcinoma with identification of high-risk and low-risk groups. Cancer 61:538–545

    Article  PubMed  CAS  Google Scholar 

  • Moll R, Levy R, Czernobilsky B et al. (1983) Cytokeratins of normal epithelia and some neoplasms of the female genital tract. Lab Invest 49:559–609

    Google Scholar 

  • Moukhtar M, Aleem FA, Hung HC et al. (1977) The reversible behavior of locally invasive endometrial carcinoma in a chromosomally mosaic (45, X/46, Xr (X)) young woman treated with Clomid. Cancer 40:2957–2966

    Article  PubMed  CAS  Google Scholar 

  • Mutch DG, Soper JT, Budwit-Novotny DA et al. (1987) Endometrial adenocarcinoma estrogen receptor content: association of clinicopathologic features with immunohistochemical analysis compared with standard biochemical methods. Am J Obstet Gynecol 157:924–931

    PubMed  CAS  Google Scholar 

  • Ng ABP, Reagan JW (1970) Incidence and prognosis of endometrial carcinoma by histologic grade and extent. Obstet Gynecol 35:437–443

    PubMed  CAS  Google Scholar 

  • Nordqvist S (1970) The synthesis of DNA and RNA in human carcinomatous endometrium in short-term incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 48:29–38

    Article  PubMed  CAS  Google Scholar 

  • Norris HJ, Tavassoli FA, Kurman RJ (1983) Endometrial hyperplasia and carcinoma. Am J Surg Pathol 7:839–847

    Article  PubMed  CAS  Google Scholar 

  • Nuovo MA, Nuovo GJ, McCaffrey M et al. (1989) Endometrial polyps in postmenopausal patients receiving tamoxifen. Int J Gynecol Pathol 8:125–131

    Article  PubMed  CAS  Google Scholar 

  • Olson N, Twiggs L, Sibley R (1982) Small-cell carcinoma of the endometrium: light microscopic and ultrastructural study of a case. Cancer 50:760–765

    Article  PubMed  CAS  Google Scholar 

  • Pertschuk LP, Beddoe AM, Gorelic LS, Shain SA (1986) Immunocytochemical assay of estrogen receptors in endometrial carcinoma with monoclonal antibodies. Cancer 57:1000–1004

    Article  PubMed  CAS  Google Scholar 

  • Piver MS, Barlow JJ, Lurrain JR, Blumenson LE (1980) Medroxyprogesterone acetate (Depo-Pro­vera) vs hydroxyprogesterone caproate (Delalutin) in women with metastatic endometrial ade­nocarcinoma. Cancer 45:268–272

    Article  PubMed  CAS  Google Scholar 

  • Puts JJG, Moesker O, Aldeweireldt J (1987) Application of antibodies to intermediate filament proteins in simple and complex tumors of the female genital tract. Int J Gyn Pathol 6:257–274

    Article  CAS  Google Scholar 

  • Robboy SJ, Bradley R (1979) Changing trends and prognostic features in endometrial cancer associated with exogenous estrogen therapy. Obstet Gynecol 54:269–277

    PubMed  CAS  Google Scholar 

  • Rodriquez J, Sen KK, Seski JC et al. (1979) Progesterone binding by human endometrial tissue during the proliferative and secretory phases of menstrual cycle and by hyperplastic and carcinomatous endometrium. Am J Obstet Gynecol 133:660–665

    PubMed  CAS  Google Scholar 

  • Ross JC, Eifel PJ, Cox RS et al. (1983) Primary mucinous adenocarcinoma of the endometrium. Am J Surg Pathol 7:715–729

    Article  PubMed  CAS  Google Scholar 

  • Sasano H, Comerfor J, Wilkinson DS et al. (1990) Serous papillary adenocarcinoma of the endometrium. Cancer 65:1545–1551

    Article  PubMed  CAS  Google Scholar 

  • Sato N, Mori T, Orenstein JM, Silverberg SG (1984) Ultrastructure of papillary serous carcinoma of the endometrium. Int J Gynecol Pathol 2:337–348

    Article  PubMed  CAS  Google Scholar 

  • Scully RE, Aguirre P, De Lellis RA (1984) Argyrophilla, serotonin, and peptide hormones in the female genital tract and its tumors. Int J Gynecol Pathol 3:51–70

    Article  PubMed  CAS  Google Scholar 

  • Segreti EM, Novotny DB, Soper JT et al. (1989) Endometrial cancer: histologic correlates of immunohistochemical localization of progesterone receptor and estrogen receptor. Obstet Gyne­col 73:780–785

    CAS  Google Scholar 

  • Simon A, Kopolovic J, Beyth Y (1988) Primary squamous cell carcinoma of the endometrium. Gynecol Oncol 31:454–461

    Article  PubMed  CAS  Google Scholar 

  • Simon WE, Hölzel F (1979) Hormone sensitivity of gynecological tumor cells in tissue culture. J Cancer Res Clin Oncol 94:307–323

    Article  PubMed  CAS  Google Scholar 

  • Sorvari TE (1969) A histochemical study of epithelial mucosubstances in endometrial and cervical adenocarcinomas with reference to normal endometrium and cervical mucosa. Acta Pathol Microbiol Scand [Suppl] 207:1–85

    Google Scholar 

  • Tavassoli F, Kraus FT (1978) Endometrial lesions in uteri resected for atypical endometrial hyperplasia. Am J Clin Pathol 70:770–779

    PubMed  CAS  Google Scholar 

  • Thom MH, Davies KJ, Senkus RJ et al. (1981) Scanning electron microscopy of the endometrial cell surface in postmenopausal women receiving oestrogen therapy. Br J Obstet Gynaecol 88:904–913

    Article  PubMed  CAS  Google Scholar 

  • Thrasher TV, Richart RM (1972) An ultrastructural comparison of endometrial adenocarcinoma and normal endometrium. Cancer 29:1713–1723

    Article  PubMed  CAS  Google Scholar 

  • Tiltman AJ (1980) Mucinous carcinoma of the endometrium. Obstet Gynecol 55:244–245

    PubMed  CAS  Google Scholar 

  • Tubiana M (1971) The kinetics of tumour cell proliferation and radiotherapy. Br J Radiol 44:325–1000

    Article  PubMed  CAS  Google Scholar 

  • Ueda G, Sato Y, Yamasaki M et al. (1977) Argyrophil cell adenocarcinoma of the endometrium. Acta Obstet Gynecol Jpn 29:1167–1168

    Google Scholar 

  • Ueda S, Tsubura A, Izumi H et al. (1983) Immunohistochemical studies on carcinoembryonic antigen in adenocarcinomas of the uterus. Acta Pathol Jpn 33:59–69

    PubMed  CAS  Google Scholar 

  • Ueda G, Yamasaki M, Inoue M et al. (1986) Immonohistochemical demonstration of HNK-1-defined antigen in gynecologic tumors with argyrophilia. Int J Gynecol Pathol 5:143–150

    PubMed  CAS  Google Scholar 

  • Ulbright TM, Roth IM (1985) Metastatic and independent cancers of the endometrium and ovary:a clinico-pathologic study of 34 cases. Hum Pathol 16:28–34

    Article  PubMed  CAS  Google Scholar 

  • Utaaker E, Iversen 0E, Skaarland E (1987) The distribution and prognostic implications of steroid receptors in endometrial carcinomas. Gynecol Oncol 28:89–100

    Article  PubMed  CAS  Google Scholar 

  • Vihko R, Jänne O, Kauppila A (1980) Steroid receptors in normal, hyperplastic and malignant human endometria. Ann Clin Res 12:208–215

    PubMed  CAS  Google Scholar 

  • Wahlström T, Korhonen M, Lindgren J, Markku S (1979) Distinction between endocervical and endometrial adenocarcinoma with immunoperoxidase staining of carcinoembryonic antigen in routine histologic tissue sections. Lancet II:1159–1160

    Article  Google Scholar 

  • Walker AM, Jick H (1979) Cancer of the corpus uteri: increasing incidence in the United States. Am J Epidemiol 110:47–51

    PubMed  CAS  Google Scholar 

  • Walker AM, Jick H (1980) Declining rates of endometrial cancer. Obstet Gynecol 56:733–736

    PubMed  CAS  Google Scholar 

  • Weiner J, Bigelow B, Demopoulos RI et al. (1980) The value of endocervical sampling in the staging of endometrial carcinoma. Diagn Gynecol Obstet 2:265–268

    PubMed  CAS  Google Scholar 

  • Welch WR, Scully RE (1977) Precancerous lesions of the endometrium. Hum Pathol 8:503–512

    Article  PubMed  CAS  Google Scholar 

  • Yamashina M, Kobara TY (1986) Primary squamous cell carcinoma with its spindle cell variant in the endometrium. Cancer 57:340–345

    Article  PubMed  CAS  Google Scholar 

  • Young PCM, Ehrlich CE, Cleary RE (1976) Progesterone binding in human endometrial carcinomas. Am J Obstet Gynecol 125:353–360

    PubMed  CAS  Google Scholar 

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© 1992 Springer-Verlag Berlin Heidelberg

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Dallenbach-Hellweg, G. (1992). Endometrial Carcinomas. In: Sasano, N. (eds) Gynecological Tumors. Current Topics in Pathology, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75941-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-75941-3_1

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