Abstract
The polymer utilized in diffusion-controlled release devices or systems plays a relatively passive role. It serves simply as a carrier and retards the rate at which the active agent is delivered to the target. Nevertheless, some polymeric carriers are designed to play a more active role in the release process. These polymers undergo chemical reactions at the target site, thereby enabling the active agent to be delivered. Such chemically activated systems fall into two broad categories (Langer, 1980; Baker, 1987):
-
i.
Physical immobilization systems, also called erodible or (bio)degradable systems in each of which the active agent, physically immobilized within the polymer network, is released by erosion of this network (Fig. 3.1a)
-
ii.
Chemical immobilization systems, in each of which the active agent is either chemically bonded to the polymer carrier backbone (pendant chain) or is part of the backbone itself (polyagents). Release occurs by hydrolytic or enzymatic degradation of the appropriate bonds (Fig. 3.1b).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allan, G. G., Beer, J. W., Cousin, M. J., Mikels, R. A.: The Biodegradative Controlled Release of Pesticides from Polymeric Substrates, pp. 7–62. In: Controlled Release Technologies: Methods, Theory, and Applications, Vol. II, A. F. Kydonieus (Ed.), CRC Press, Boca Raton, Florida (1980)
Baker, R. W.: Controlled Release of Biologically Active Agents, pp. 84–131, John Wiley and Sons, New York (1987)
Baker, R. W., Lonsdale, H. K.: Erodible Controlled Release Systems. In: Preprints of papers presented at the 171st meeting, ACS, Division of Organic Coatings and Plastics Chemistry 36 (1), 235–242 (1976)
Batz, H.-G.: Polymeric Drugs, Adv. in Pol. Sci. 23, 25–53 (1977)
Cooney, D. O.: Effect of Geometry on the Dissolution of Pharmaceutical Tablets and Other Solids: Surface Detachment Kinetics Controlling, AIChE J. 18, 446–449 (1972)
Duncan, R., Cable, H. C., Lloyd, J. B., Rejmanova, P., Kopecek, J.: Polymers Containing Enzymatically Degradable Bonds, 7. Design of Oligopeptide Side-Chains in Poly [n-(2-hydroxypropyl)methacrylamide] Copolymers to Promote Efficient Degradation by Lysosomal Enzymes, Makromol. Chem. 184, 1997–2008 (1983)
Duncan, R., Kopecek, J.: Soluble Synthetic Polymers as Potential Drug Carriers, Adv. in Pol. Sc. 57, 51–101 (1984)
Franzmann, G., Ringsdorf, H.: Pharmakologisch Aktive Polymere, 12. Depotformen von Chlorambucil durch Kovalente Bindung an Polymere, Makromol. Chem. 177, 2547–2552 (1977)
Harris, F. W.: Polymers Containing Pendent Pesticide Substituents, pp. 63–82. In: Controlled Release Technologies: Methods, Theory, and Applications, Vol. II, A. F. Kydonieus (Ed.), CRC Press, Boca Raton, Florida (1980)
Harris, F. W., Aulabaugh, A. E., Case, R. D., Dykes, M. K., Feld, W. A.: Polymers Containing Pendent Herbicide Substituents: Preliminary Hydrolysis Studies. In: Controlled Release Polymeric Formulations, D. R. Paul and F. W. Harris (Eds.), ACS Symposium Series 33, 222–230(1976)
Harris, F. W., Dykes, M. R., Baker, J. A., Aulabaugh, A. E.: Polymers Containing Pendant Herbicide Substitutes: Hydrolysis Studies II. In: Controlled Release Pesticides, H. B. Scher (Ed.), ACS Symposium Series 53, 102–111 (1977)
Heller, J.: Controlled Release of Biologically Active Compounds from Bioerodible Polymers, Biomaterials 1, 51–57 (1980)
Heller, J., Baker, R. W., Gale, R. M., Rodin, J. O.: Controlled Drug Release by Polymer Dissolution. I. Partial Esters of Maleic Anhydride Copolymers — Properties and Theory, J. Appl. Polym. Sci. 22, 1991–2009 (1978)
Heller, J., Baker, R. W.: Theory and Practice of Controlled Drug Delivery from Bioerodible Polymers, pp. 1–17. In: Controlled Release of Bioactive Materials, R. W. Baker (Ed.), Academic Press, New York (1980)
Heller, J., Trescony, P. V.: Controlled Drug Release by Polymer Dissolution. II: Enzyme-Mediated Delivery Device, J. Pharm. Sci. 68, 919–921 (1979)
Hoffman, V., Ringsdorf, H., Seganova, A.: Pharmakologisch-Aktiv Polymere, 19. Polymere mit Kovalent Gebundenem Streptomycinsulfat, Makromol. Chem. 180, 837–841 (1979)
Hopfenberg, H. B.: Controlled Release from Erodible Slabs, Cylinders, and Spheres. In: Preprints of papers presented at the 171st meeting, ACS, Division of Organic Coatings and Plastics Chemistry 36 (1) 229–234 (1976)
Kopecek, J.: Controlled Biodegradability of Polymers — A Key to Drug Delivery Systems, Biomaterials 5, 19–25 (1984)
Langer, R.: Polymeric Delivery Systems for Controlled Drug Release, Chem. Eng. Commun. 6, 1–48 (1980)
Langer, R., Peppas, N.: Chemical and Physical Structure of Polymers as Carriers for Controlled Release of Bioactive Agents: A Review:, J. Macromol. Sci. — Rev. Macromol. Chem. Phys. C23, 61–126 (1983)
Lee, P. I.: Diffusional Release of a Solute from a Polymeric Matrix — Approximate Analytical Solutions, J. Membrane Sci. 7, 255–275 (1980)
Lee, P. I.: Controlled Drug Release from Polymeric Matrices Involving Moving Boundaries, pp. 39–48. In: Controlled Release of Pesticides and Pharmaceuticals, D. H. Lewis (Ed.), Plenum Publishing Corp., New York (1981)
McCormick, C. L., Fooladi, M.: Synthesis, Characterization, and Release Mechanisms of Polymers Containing Pendant Herbicides. In: Controlled Release Pesticides, H. B. Scher (Ed.), ACS Symposium Series 53, 112–125 (1977)
Neogi, A. N., Allan, G. G.: Controlled-Release Pesticides: Concepts and Realization, pp. 195–224. In: Controlled Release of Biologically Active Agents, A. C. Tanquary and R. E. Lacey (Eds.), Plenum Press, New York (1974)
Petersen, R. V., Andersen, C. G., Fang, S.-M., Gregonis, D. E., Kim, S. W., Feijen, J., Anderson, J. M., Mitra, S.: Controlled Release of Progestins from Poly (α-Amino Acid) Carriers, pp. 45–60. In: Controlled Release of Bioactive Materials, R. Baker (Ed.), Academic Press, New York (1980)
Pitt, C. G., Schindler, A.: The Design of Controlled Drug Delivery Systems Based on Biodegradable Polymers, pp. 17–30. In: Biodegradables and Delivery Systems for Contraception, E. S. I. Hafez and W. A. A. van Os (Eds.), MTP Press, Lancaster, England (1980)
Pitt, C. G., Schindler, A.: Biodegradation of Polymers, pp. 53–80. In: Controlled Drug Delivery, Vol. I, Basic Concepts, S. D. Bruck (Ed.), CRC Press, Boca Raton, Florida (1983)
Pittman, Jr., C. U., Lawyer, K. R., Ramachandran, K. S.: Polymer-Bound Fungicides for Paints. In: Biological Activities of Polymers, C. E. Carraher, Jr. and C. G. Gebelein (Eds.), ACS Symposium Series 186, 35–53 (1982)
Rejmanova, P., Kopecek, J., Pohl, J., Baudys, M., Kostka, V.: Polymers Containing Enzymatically Degradable Bonds. 8. Degradation of Oligopeptide Sequences in N-(2-hydroxypropyl)methacrylamide Copolymers by Bovine Spleen Cathepsin B, Makromol. Chem. 184, 2009–2020 (1983)
Ringsdorf, H.: Structure and Properties of Pharmacologically Active Polymers, J. Polym. Sci. Polym. Symp. 51, 135–153 (1975)
Ringsdorf, H.: Synthetic Polymeric Drugs, pp. 197–223. In: Polymeric Delivery Systems, R. J. Kostelnik (Ed.), Gordon and Breach Science Publishers, New York (1978)
Schindler, A., Jeffcoat, R., Kimmel, G. L., Pitt, C. A., Wall, M. E., Zweidinger, R.: Biodegradable Polymers for Sustained Drug Delivery, pp. 251–286. In: Contemporary Topics in Polymer Science, Vol. 2, E. M. Pearce and J. R. Schaefgen (Eds.), Plenum Press, New York (1977)
Thombre, A. G.: Mechanism and Kinetics of Release from Two Controlled Drug Delivery Devices, pp. 9–106, PhD Dissertation, University of Kansas, Lawrence, Kansas (1985)
Thombre, A. G., Himmelstein, K. J.: Modelling of Drug Release Kinetics from a Laminated Device having an Erodible Drug Reservoir, Biomaterials 5, 250–254 (1984)
Tojo, K., Miyanami, K., Fan, L. T.: Mathematical Simulation of Membrane-Moderated Controlled Release, Powder Technology 35, 89–96 (1983)
Torchilin, V. P., Tischenko, E. G., Smirnov, V. N., Chazov, E. L: Immobilization of Enzymes on Slowlv Soluble Carriers, J. Biomed. Mater. Res. 11, 223–235 (1977)
Wise, D. L., Schwope, A. D., Harrigan, S. E., McCarthy, D. A., Howes, J. F.: Sustained Delivery of a Narcotic Antagonist from Lactic/Glycolic Acid Copolymer Implants, pp. 75–86. In: Polymeric Delivery Systems, R. J. Kostelnik (Ed.), Gordon and Breach Science Publishers, New York (1978)
Yaacobi, Y., Lotan, N., Sideman, S.: A Hybrid System for Zero Order Drug Delivery Regimen, Polym. Sci. Technol. 34, 379–386 (1986)
Yolles, S., Eldridge, J., Leafe, T., Woodland, J. H. R., Blake, D. R., Meyer, F.: Long-Acting Delivery Systems for Narcotic Antagonists, pp. 177–193. In: Controlled Release of Biologically Active Agents, A. C. Tanguary and R. E. Lacey (Eds.), Plenum Press, New York (1974)
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag, Berlin Heidelberg
About this chapter
Cite this chapter
Fan, Lt., Singh, S.K. (1989). Chemical Reaction Controlled Release. In: Controlled Release. Polymers, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74507-2_3
Download citation
DOI: https://doi.org/10.1007/978-3-642-74507-2_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74509-6
Online ISBN: 978-3-642-74507-2
eBook Packages: Springer Book Archive