Abstract
We have previously reported that ceftriaxone (CRO), an oxi-imino-amino 2 thiazolyl cephalosporin, does not significantly alter the functions of human polymorphonuclear neutrophils (PMNs) [6]. At subinhibitory concentrations, however, CRO alters Staphylococcus aureus and Klebsiella pneumoniae in such a way that these CRO-treated bacteria become more sensitive to PMN killing and in particular to a non-O2-dependent killing system [7], Since Bassler et al. [1] have reported that CRO cooperates with PMNs for the killing of Pseudomonas aeruginosa, it was of interest to analyze whether subinhibitory concentrations of CRO could alter this bacterial strain.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bassler M, Blaschke H, Just M, Daschner FD (1982) Effect of ceftriaxone on Pseudomonas aeruginosa and Staphylococcus aureus in broth, serum and in combination with human polymorphonuclear leukocytes. Chemotherapy 28:390–396
Gemmel CG (1984) Potentiation of phagocytosis of pathogenic bacteria by exposure to low concentrations of antibiotics. J Antimicrob Chemother 13:407–409
Grassi GG, Fietta A, Sacchi F, De Rose V (1984) Influence of ceftriaxone on natural defence system. Am J Med 77:37–41
Kadurugamuwa JL, Anwar H, Brown MRW, Zak O (1985 a) Protein antigens of encapsulated Klebsiella pneumoniae surface exposed after growth in the presence of subinhibitory concentrations of cephalosporins. Antimicrob Agents Chemother 28:195–199
Kadurugamuwa JL, Anwar H, Brown MRW, Zak O (1985 b) Exposure of protein antigens and reduction of siderophore production after growth of gram-negative bacteria in subinhibitory concentration of cephalosporins. In: Adam D, Hahn H, Opferkuch W (eds) The influence of antibiotics on the host parasite relationship. Springer, Berlin Heidelberg New York, pp 36–47
Labro MT, Babin-Chevaye C, Pochet Y, Hakim J (1987 a) Interaction of ceftriaxone with human polymorphonuclear neutrophil function. J Antimicrob Chemother 20:849–855
Labro MT, Babin-Chevaye C, Pochet Y, Hakim J (1987 b) Consequency of ceftriaxone-induced alterations of bacteria on neutrophil bactericidal function. J Antimicrob Chemother 20:857–869
Lorian V (1978) Effects of subinhibitory concentrations of antibiotics on bacteria. Curr Chemother 1:72–78
Lorian V (1985) Low concentrations of antibiotics. J Antimicrob Chemother 15 [Suppl A]:15–26
Lorian V (1986) Effect of low antibiotic concentration on bacteria: effects on ultrastructure, their virulence and susceptibility to immunodefenses. In: Lorian V (ed) Antibiotics in laboratory medicine. Williams and Wilkins, Baltimore, pp 596–668
Lorian V, Atkinson B (1984) Bactericidal effect of polymorphonuclear neutrophils on antibiotic-induced filaments of gram negative bacilli. J Infect Dis 149:719–727
Mychajlonka M, Mac Dowell TD, Shockman GD (1980) Inhibition of peptidoglycan, ribonucleic acid and protein synthesis in tolerant strains of Streptococcus mutans. Antimicrob Agents Chemother 17:572–582
Roszkowski W, Ciborowski P, Ko HKL, Schumacher-Perdreau F, Roszkowski K, Jeljaszewicz J, Pulverer G (1985) The effect of subinhibitory concentration of selected antibiotics on bacteria-phagocyte interaction. In: Adam D, Hahn H, Opferkuch W (eds) The influence of antibiotics on the host parasite relationship II. Springer, Berlin Heidelberg New York, pp 178–187
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Labro, M.T., Babin-Chevaye, C., Hakim, J. (1989). Influence of Subinhibitory Concentrations of Ceftriaxone on Opsonic Requirements of Pseudomonas aeruginosa . In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-73653-7_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73655-1
Online ISBN: 978-3-642-73653-7
eBook Packages: Springer Book Archive