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Growth Rate, Iron Depletion, and a Sub-Minimal Inhibitory Concentration of Penicillin G Affect the Surface Hydrophobicity of Staphylococcus aureus

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The Influence of Antibiotics on the Host-Parasite Relationship III

Abstract

The surface composition of bacteria is important in interactions with the host [6, 11, 50] and with antibiotics [7, 8]. The surface is altered by the growth environment [6, 16, 50] so that bacteria become typical of it. Thus bacteria grown in vitro and in vivo reflect both genotypic and phenotypic changes [6, 14, 20, 51]. More attention to in vivo characteristics would enhance understanding of infectious processes, and in vitro design should account for this. We report on batch-culture conditions that approximate to in vivo conditions and that alter surface hydrophobicity (SH).

This work was partly supported by grants from the Medical Research Council and the Cystic Fibrosis Research Trust. PAGD was supported by a grant from the Science and Engineering Research Council.

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Author notes

  1. P. A. G. Domingue

    Present address: Department of Biology, University of Calgary, 2500 University Drive N. W., Calgary, Alberta, Canada, T2N 1N4

Authors and Affiliations

  1. Microbiology Research Group, Pharmaceutical Sciences Institute, Department of Pharmaceutical Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK

    P. A. G. Domingue & M. R. W. Brown

  2. Sandoz Research Institute, Brunner Str. 59, 1235, Vienna, Austria

    E. Schwarzinger

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  1. P. A. G. Domingue
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Editors and Affiliations

  1. Institut für Medizinische Mikrobiologie der Medizinischen Fakultät der RWTH Aachen, Pauwelsstrasse, D-5100, Aachen, Germany

    Günther Gillissen

  2. Abteilung für Theoretische und Klinische Medizin Lehrstuhl für Medizinische Mikrobiologie, Ruhr-Universität Bochum, Universitätsstrasse 150, D-4630, Bochum, Germany

    Wolfgang Opferkuch

  3. Hygiene-Institut der Universität zu Köln, Goldenfelsstrasse 19-21, D-5000, Köln 41, Germany

    Georg Peters  & Gerhard Pulverer  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Domingue, P.A.G., Schwarzinger, E., Brown, M.R.W. (1989). Growth Rate, Iron Depletion, and a Sub-Minimal Inhibitory Concentration of Penicillin G Affect the Surface Hydrophobicity of Staphylococcus aureus . In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_7

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  • DOI: https://doi.org/10.1007/978-3-642-73653-7_7

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