Abstract
Since the introduction of nalidixic acid in 1962, several compounds of this class (4-quinolones and in particular the fluoroquinolones), have been synthesized. These molecules have been shown to display an increased antibacterial potency and a broader spectrum. However, concerning potential direct interaction with the host defense system — in particular polymorphonuclear neutrophils (PMNs) — few data have been reported [3, 4, 8] and they do not indicate a significant increase in PMN function. On the contrary, several authors have shown that low concentrations of quinolones may alter bacteria in such a manner that these altered pathogens are significantly more sensitive than control ones to PMN killing [8, 9, 13]. The aim of our work was to analyze the effects of a low concentration of 4-quinolones on Pseudomonas aeruginosa, a strain which has lately emerged as an important pathogen with increasing resistance to antimicrobial agents.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cohen J, Mc Connell JS (1986) Release of endotoxin from bacteria exposed to ciprofloxacin and its prevention with polymyxin B. Eur J Clin Microbiol 5(1): 13–17
Diver JM, Wise R (1986) Morphological and biochemical changes in Escherichia coli after exposure to ciprofloxacin. J Antimicrob Chemother 18 [Suppl D]:31–41
Duncker D, Ulimann U (1984) Einfluß von Ciprofloxacin, Enoxacin und Norfloxacin auf die Phagozytose humaner neutrophiler Granulozyten, gemessen mit der Chemilumineszenz. FAC 3–5:633–635
Forsgren A, Bergkvist PI (1985) Effect of ciprofloxacin on phagocytosis. Eur J Clin Microbiol 4(6):575–577
Labro MT, Babin-Chevaye C, Hakim S (1987a) Ceftriaxone-induced alteration of Pseudomonas aeruginosa in relation to the bactericidal function of human neutrophils. Proceedings of the 15th ICC Istanbul, July 19–24, vol 1. Berkada B, Kuemmerle HP (eds) pp 782–784
Labro MT, Babin-Chevaye C, Hakim S (1988) Influence of subinhibitory concentrations of ceftriaxone on opsonization and killing of pseudomona aeruginosa by human neutrophils. J Antimicrob Chemother 22:341–352
Modrzakowski MC, Dosch-Meier D, Hodinka RL (1983) Effect of rat polymorphonuclear leukocyte granule components on the growth and survival of Pseudomonas aeruginosa and Salmonella typhimurium. Can J Microbiol 29:1339–1343
Pulverer G, Peters G (1986) Investigations on ofloxacin: antibacterial activity and influence on the immune system. Infection 14 [Suppl 4] 245–247
Roskowski W, Ciborowski P, Ko HL, Schumacher-Perdreau F, Rozkowski K, Jeljaszewicz J, Pulverer G (1985) The effect of subinhibitory concentrations of selected antibiotics on bacteria-phagocyte interaction. In: Adam D, Hahn H, Opferkuch W (eds) The influence of antibiotics on the host-parasite relationship, II. Springer, Berlin Heidelberg New York, pp 179–186
Shen LL, Pernet AG (1985) Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drug is DNA. Proc Natl Acad Sci USA 82:307–311
Smith JT (1984) Awakening the slumbering potential of the 4-quinolones antibacterials. Pharm J 233:299–305
Watanabe Y, Tawara S, Mine Y, Kikuchi H (1986) Synergism of cephalosporins at subinhibitory concentrations and polymorphonuclear leukocytes on phagocytic killing of Escherichia coli and its mode of action. J Antibiot (Tokyo) 39:294–303
Williams P (1987) Sub MICs of cefuroxime and ciprofloxacin influence interaction of complement and immunoglobulins with Klebsiella pneumoniae. Antimicrob Agents Chemother 31(5):758–762
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Labro, M.T., Bryskier, A., Babin-Chevaye, C., Hakim, J. (1989). Pseudomonas aeruginosa: Alterations Induced by Low Concentrations of 4-Quinolones. In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-73653-7_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73655-1
Online ISBN: 978-3-642-73653-7
eBook Packages: Springer Book Archive