Abstract
Human neutrophils have been shown to concentrate radioactively labeled clindamycin approximately 12-fold compared with its concentration in the medium [1]. This concentrating effect was shown in this study to be dependent upon cellular energy at 37 °C. The amount of radioactively labeled clindamycin associated with formalin-fixed neutrophils was about twice the concentration of the medium and was interpreted by the authors to represent the binding of the antibiotic to the surface of the neutrophils.
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Reference
Hand WL, King-Thompson NL, Steinberg TH (1983) Interactions of antibiotics and phagocytes. J Antimicrob Chemother 12 [Suppl C]:1
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© 1989 Springer-Verlag Berlin Heidelberg
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Amaral, L., Lorian, V. (1989). Enzymatic Conversion of [3H]Clindamycin by the Human Neutrophil. In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_13
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DOI: https://doi.org/10.1007/978-3-642-73653-7_13
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