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Traditional Chinese Medicines and Drugs in Relation to the Host-Defense Mechanism

  • Conference paper
The Influence of Antibiotics on the Host-Parasite Relationship III

Abstract

Pseudomonas aeruginosa infection is observed mostly under immunosuppressive conditions. We have clarified that the combined use of antibiotics and specific antibodies is effective against mouse P. aeruginosa infection in vivo [1–5]. From our previous experiments, traditional Chinese medicines and crude drugs are known to cause stimulation of the reticuloendothelial system [6]. Kiger et al. [7] found that P. aeruginosa treatment (108 killed organisms) had a capacity to induce release of tumor-necrotizing factor in the serum of bacille Calmette-Guérin (BCG)-pretreated mice to the same extent as lipopolysaccharide (LPS) treatment. Our experiments on tumor necrosis factor (TNF) have demonstrated the production of TNF as well as its associated severe toxicity [8–10]. Recently, recombinant human TNF has been mass produced and many actions of this factor have become clear. We have found that by employing traditional Chinese medicines as priming agents, the toxic symptoms after administration of LPS could be reduced.

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References

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Authors and Affiliations

  1. Department of Internal Medicine, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108, Japan

    N. Satomi, A. Sakurai & K. Haranaka

  2. Department of Biochemistry, Nihon University School of Medicine, 30-1, Ooyaguchi-Kamimachi, Itabashi-ku, Tokyo 173, Japan

    R. Haranaka

Authors
  1. N. Satomi
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  2. A. Sakurai
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  3. R. Haranaka
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  4. K. Haranaka
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Editor information

Editors and Affiliations

  1. Institut für Medizinische Mikrobiologie der Medizinischen Fakultät der RWTH Aachen, Pauwelsstrasse, D-5100, Aachen, Germany

    Günther Gillissen

  2. Abteilung für Theoretische und Klinische Medizin Lehrstuhl für Medizinische Mikrobiologie, Ruhr-Universität Bochum, Universitätsstrasse 150, D-4630, Bochum, Germany

    Wolfgang Opferkuch

  3. Hygiene-Institut der Universität zu Köln, Goldenfelsstrasse 19-21, D-5000, Köln 41, Germany

    Georg Peters  & Gerhard Pulverer  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Satomi, N., Sakurai, A., Haranaka, R., Haranaka, K. (1989). Traditional Chinese Medicines and Drugs in Relation to the Host-Defense Mechanism. In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-73653-7_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73655-1

  • Online ISBN: 978-3-642-73653-7

  • eBook Packages: Springer Book Archive

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