Skip to main content

Efficacy and duration of action of three doses of Zatebradine (ULFS 49 CL) in patients with chronic angina pectoris compared to placebo

  • Conference paper
Sinus node inhibitors

Abstract

Zatebradine (ULFS 49 CL) is a member of a new class of drugs, the so-called sinus node inhibitors that specifically reduce the spontaneous rate of depolarization of the pacemaker cells in the sino-atrial node [5, 6], leading to a decrease in heart rate.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Balakumaran K, Jovanovic A, Fels Ph. W, van Es GA, Bokslag M, Lubsen J, Hugenholtz PG (1987) AT 567 (alinidine) in stable angina: a comparison with metoprolol. Eur Heart J 8 (Suppl L) 153–157.

    PubMed  Google Scholar 

  2. Ferro G, Spinelli L, Duilio C, Spadafora M, Cinquegrana G, Condorelli M (1990) Alinidine in chronic stable angina: The effect on diastolic perfusion time. Cardiology 77: 287–294.

    Article  PubMed  CAS  Google Scholar 

  3. Häuf DF, Rose P. Schnellbacher K. Roskamm H (1990) Effect of ULFS 49 CL in patients with stable angina pectoris. Z Kardiol 79 (Suppl 1): Abstr P556.

    Google Scholar 

  4. IndoM C, C, Guth BD, Miura T, Miyazaki S, Schulz R, Ross J Jr. (1989) Mechanism of improved ischemic regional dysfunction by bradycardia; Studies on ULFS 49 in swine. Circulation 80 No. 4: 983–993.

    Article  PubMed  CAS  Google Scholar 

  5. Lillie C, Kobinger W (1986) Investigations into the bradycardic efects of ULFS 49 CL in isolated guinea pig atria. J Cardiovasc Pharmacol 8: 791–797

    PubMed  CAS  Google Scholar 

  6. Van Ginneken ACG, Bouman LN, Jongsma HI, Duivenvoorden JJ, Opthof T, Giler WR (1987) Alinidine as a model of the mode of action of specific bradycardic agents on SA node activity. Eur Heart J 8 (Suppl L): 25–33.

    PubMed  Google Scholar 

  7. Van Woerkens LJ, van der Giessen WJ, Verdouw PD (1991) The selective bradycardic effects of ULFS 49 do not adversely affect left ventricular function in conscious pigs with chronic coronary artery occlusion. Cardiovasc Drugs Ther 5: 000–000 submitted for publication.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

About this paper

Cite this paper

Baiker, W., v. Czako, E., Keck, M., Nehmiz, G. (1991). Efficacy and duration of action of three doses of Zatebradine (ULFS 49 CL) in patients with chronic angina pectoris compared to placebo. In: Hjalmarson, Å., Remme, W.J. (eds) Sinus node inhibitors. Steinkopff. https://doi.org/10.1007/978-3-642-72458-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72458-9_6

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0861-3

  • Online ISBN: 978-3-642-72458-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics