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Antiischemic, antianginal, and hemodynamic effects of ULFS 49 CL (a new heart-rate-reducing agent) in patients with angiographically proven CAD

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Sinus node inhibitors

Abstract

ULFS 49 CL, a so-called sinus node inhibitor, does not affect β-adrenergic or muscarinic receptors at therapeutical plasma concentrations in man. The compound’s underlying mechanism of action to decrease heart rate can be explained by an inhibition of the if-current, which seems to be responsible for the spontaneous depolarization of the pacemaker cells in the sino-atrial node [1, 2]. Like β-blockers, the substance is expected to produce a reduction in heart rate. Through this mechanism ULFS 49 CL may result in antianginal and/or antiischemic efficacy in patients with angina pectoris. At present, no data are available on its antiischemic potential. The aim of the present multicenter trial was to investigate the antianginal, antiischemic, and hemodynamic effects of ULFS 49 CL, a new heart-rate-reducing compound, in patients with stable angina pectoris.

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References

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Author information

Authors and Affiliations

  1. Kerckhoff-Klinik of the Max-Planck Society, Benekestraße 2, 6350, Bad Nauheim, Germany

    Dr. H. F. Pitschner, E. Muno, F. Vens-Cappel, B. Schulte & M. Schlepper

  2. Dept. of Medicine, Cardiology, Boehringer Ingelheim, Ingelheim, Germany

    V. de Moura-Sieber

  3. Dept. of Medicine, Cardiology, Dr. Karl Thomae GmbH, Biberach, Germany

    W. Baiker

Authors
  1. Dr. H. F. Pitschner
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  2. E. Muno
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  3. F. Vens-Cappel
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  4. B. Schulte
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  5. M. Schlepper
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  6. V. de Moura-Sieber
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  7. W. Baiker
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Editor information

Editors and Affiliations

  1. Wallenberg Laboratory for Cardiovascular Research Sahlgren’s Hospital, Gothenburg University, S-41345, Gothenburg, Sweden

    Å. Hjalmarson (Professor of Cardiology) (Professor of Cardiology)

  2. Cardiovascular Research Foundation, STICARES, Valkeniersweg 79, NL-3075 AZ, Rotterdam, The Netherlands

    W. J. Remme

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© 1991 Dr. Dietrich Steinkopff Verlag GmbH & Co. KG, Darmstadt

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Pitschner, H.F. et al. (1991). Antiischemic, antianginal, and hemodynamic effects of ULFS 49 CL (a new heart-rate-reducing agent) in patients with angiographically proven CAD. In: Hjalmarson, Å., Remme, W.J. (eds) Sinus node inhibitors. Steinkopff. https://doi.org/10.1007/978-3-642-72458-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-72458-9_5

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0861-3

  • Online ISBN: 978-3-642-72458-9

  • eBook Packages: Springer Book Archive

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