Skip to main content
SpringerLink
Log in

Die Bedeutung der Allopeptid-induzierten Expression von Fas-Ligand (FasL) im Parenchym allogener Herztransplantate als Ursache der spenderspezifischen Toleranzinduktion

The impact of allopeptide induced expression of Fas-ligand in allogeneic cardiac grafts mediated by donor specific tolerance induction

  • Conference paper
Chirurgisches Forum ’98

Part of the book series: Langenbecks Archiv für Chirurgie ((FORUMBAND,volume I/98))

  • 36 Accesses

Zusammenfassung

Die allogene Transplantatabstoßung bedient sich zweier unterschiedlicher Wege der Antigenerkennung, zum einen der direkten Präsentation allogener Haupthistokompatibilitätsantigene (MHC) auf Transplantatzielzellen an T-Lymphozyten und zum anderen der indirekten Präsentation immunogener Spenderantigene auf empfängereigenen antigenpräsentierenden Zellen (APCs) an Effektorzellen der Empfängerimmunantwort [1, 2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Shoskes DA, Wood KJ (1994) Indirect presentation of MHC antigens in transplantation. Immunol Today 15: 32–38

    Article  PubMed  CAS  Google Scholar 

  2. Sayegh MH, Watschinger B, Carpenter CB (1994) Mechanisms of T cell recognition of alloantigen. The role of peptides. Transplantation 57: 1295–1302

    Article  PubMed  CAS  Google Scholar 

  3. Fangmann J, Dalchau R, Priestley CA, Fabre JW (1992) T cell recognition of donor major histocompatibility complex class I peptides during allograft rejection. Eur J Immunol 22: 1525–1530

    Article  PubMed  CAS  Google Scholar 

  4. Ono K, Lindsey ES (1969) Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 57: 225–229

    PubMed  CAS  Google Scholar 

  5. Zavazava N, Fändrich F, Ott KAY, Freese A, Turnewitsch K (1996) Rat MHC class I peptides are immunogenic. Transplant Int 9: 337–339

    Article  Google Scholar 

  6. Cordell JL, Fallini B, Erber BN, Ghosh AK, Mason DY (1984) Immunoenzymatic labeling of monoclonal antibodies using immunocomplexes of alkaline posphatases and monoclonal anti-alkaline phosphatase ( APAAP complexes ). J Histochem Cytochem 32: 219–229

    Article  PubMed  CAS  Google Scholar 

  7. Sayegh MH, Perico N, Gallon L, Imberti O, Hancock WW, Remuzzi G, Carpenter CB (1994) Mechanisms of acquired thymic alloresponsiveness to renal allografts. Thymic recognition of immunodominant allo-MHC peptides induces peripheral cell anergy. Transplantation 58: 125–132

    PubMed  CAS  Google Scholar 

  8. Chowdury NC, Murphy B, Sayegh MH, Jin MX, Roy DK, Hardy MR, Oluwole SF (1996) Acquired systemic tolerance to rat cardiac allografts induced by intrathymic inoculation of synthetic polymorphic MHC class I allopeptides. Transplantation 62: 1878–1882

    Article  Google Scholar 

  9. Bellgrau D, Gold D, Selawry H, Moor J, Franzusoff A, Duke RC (1995) A role for CD95 ligand in preventing graft rejection. Nature 377: 630–632

    Article  PubMed  CAS  Google Scholar 

  10. Benichou G, Fedoseyeva EV, Olsen CA, Geysen HM, McMillan M, Sercarz EE (1994) Disruption of the determant hierarchy on a self-MHC peptide: Concomitant tolerance induction to the dominant determinant and priming to the cryptic self-determinant. Int Immunol 6: 131–138

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Allgemeine und Thoraxchirurgie, Christian-Albrechts-Universität zu Kiel, Deutschland

    B. Dreßke, J. Schröder, B. Kremer & F. Fändrich

  2. Institut für Immunologie, Christian-Albrechts-Universität zu Kiel, Deutschland

    N. Zavazava

Authors
  1. B. Dreßke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Schröder
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Zavazava
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. Kremer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Fändrich
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Chirurgischen Universitätsklinik Zentrum für Chirurgie, Kirschnerstr. 1 (INF 110), 69120, Heidelberg, Deutschland

    Ch. Herfarth (Geschäftsführender Direktor) (Geschäftsführender Direktor)

  2. Zentrum Operative Medizin I, Philipps-Universität, Baldingerstraße, 35043, Marburg, Deutschland

    M. Rothmund (Leiter der Klinik für Allgemeinchirurgie) (Leiter der Klinik für Allgemeinchirurgie)

  3. Deutschen Gesellschaft für Chirurgie, Steinhölzle 16, 89198, Westerstetten, Deutschland

    W. Hartel (Generalsekretär) (Generalsekretär)

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Dreßke, B., Schröder, J., Zavazava, N., Kremer, B., Fändrich, F. (1998). Die Bedeutung der Allopeptid-induzierten Expression von Fas-Ligand (FasL) im Parenchym allogener Herztransplantate als Ursache der spenderspezifischen Toleranzinduktion. In: Herfarth, C., Rothmund, M., Hartel, W. (eds) Chirurgisches Forum ’98. Langenbecks Archiv für Chirurgie, vol I/98. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72182-3_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72182-3_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64277-0

  • Online ISBN: 978-3-642-72182-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation