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Apoptosis and the Cytopathic Effects of Reovirus

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Reoviruses II

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 233/2))

Abstract

Reoviruses are cytolytic viruses which cause the death of infected cells in vitro and in vivo. The relationship between events involved in the production of virus and death of the infected cell is not clearly understood. Studies of virus-induced biochemical and morphological changes in cells, i.e., cytopathic effects, have begun to define both viral and cellular factors involved in virus-induced cell death. The description and definition of apoptosis as a mechanism of cell death distinct from necrosis has provided a framework for elucidating the roles of these viral and cellular factors in the cell death process. The demonstration that reovirus induces apoptosis in vitro and in vivo identifies apoptosis as an important component of reovirus-induced cytopathic effects and tissue injury. In this chapter we review the current data describing reovirus-induced apoptosis and propose that many of the previously described cytopathic effects of reovirus infection represent events which initiate or comprise steps in the apoptotic process.

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Authors and Affiliations

  1. Department of Neurology, University of Colorado Health Sciences Center, Denver, CO, 80262, USA

    S. M. Oberhaus

  2. Department of Microbiology and Immunology, East Carolina University School of Medicine, Greenville, NC, 27858, USA

    S. M. Oberhaus

  3. Departments of Pediatrics, and Microbiology and Immunology and Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA

    T. S. Dermody

  4. Departments of Neurology, and Microbiology, Immunology, and Medicine, University of Colorado Health Sciences Center, 4200 East 9th Ave., Denver, CO, 80262, USA

    K. L. Tyler

  5. Neurology Service, Denver Veterans Affairs Medical Center, 1055 Clermont St., Denver, CO, 80220, USA

    K. L. Tyler

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  1. S. M. Oberhaus
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Editors and Affiliations

  1. Health Sciences Center, Department of Neurology, University of Colorado, 4200 East 9th Avenue, Campus Box B-182, Denver, CO, 80262, USA

    Kenneth L. Tyler M.D.

  2. Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Oberhaus, S.M., Dermody, T.S., Tyler, K.L. (1998). Apoptosis and the Cytopathic Effects of Reovirus. In: Tyler, K.L., Oldstone, M.B.A. (eds) Reoviruses II. Current Topics in Microbiology and Immunology, vol 233/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72095-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-72095-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

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