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Clearance of Virus by T Lymphocytes Mediating Delayed Type Hypersensitivity

  • Conference paper
Arenaviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 134))

Abstract

The mammalian defense system against invading microorganisms has been investigated for more than a hundred years, with the ultimate goal, therapeutically and prophylactically. to overcome human disease caused by infectious agents. Not surprisingly, at present such experimentation focuses considerably on viruses, since these agents do not to any noteworthy degree respond to antibiotics or chemotherapy. In spite of this research, however, it is still uncertain by which mechanisms exactly viruses are cleared from the infected host, and how virus-induced, cell-mediated pathology develops. Although the phenomenon of delayed type hypersensitivity (DTH) — of all the immunologically specific mechanisms believed to be important in virus elimination — was the first to be discovered, it is still far from fully understood.

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  1. Institute of Medical Microbiology, Copenhagen University, Juliane Maries Vej 22, 2100, Copenhagen Ø, Denmark

    O. Marker & A. R. Thomsen

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  1. O. Marker
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  1. Department of Immunology, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Michael B. A. Oldstone M.D.

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Marker, O., Thomsen, A.R. (1987). Clearance of Virus by T Lymphocytes Mediating Delayed Type Hypersensitivity. In: Oldstone, M.B.A. (eds) Arenaviruses. Current Topics in Microbiology and Immunology, vol 134. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71726-0_7

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