Abstract
The administration of opioids by the epidural route pioneered by Behar et al.(1) has achieved great popularity as a means of providing postoperative analgesia. Although morphine has been the commonest opioid to be used by either intrathecal or epidural administration(2–7), other opioids such as pethidine, methadone, buprenorphine, fentanyl and diamorphine have also been used in a search for prolonged analgesia free of undesirable side effects. Although most authors have described the advantages and benefits of epidural or intrathecal opioids, there has been much concern about the wisdom of using such methods of postoperative pain relief on general hospital wards in view of case reports of profound ventilatory depression occurring either shortly after, or many hours after, drug administration(8–11).
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References
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© 1982 Springer-Verlag Berlin Heidelberg
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Cooper, G.M., Goodman, N.W., Prys-Roberts, C., Jacobson, L., Douglas, G.A., Dye, J. (1982). Ventilatory Effects of Epidural Diamorphine — A Comparison with Epidural Lignocaine. In: Prys-Roberts, C., Vickers, M.D. (eds) Cardiovascular Measurement in Anaesthesiology. European Academy of Anaesthesiology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68690-0_8
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DOI: https://doi.org/10.1007/978-3-642-68690-0_8
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