Abstract
The knowledge of the pharmacokinetic profile of a drug is one essential for its rational dosing. Kinetic parameters such as total clearance, volumes of distribution and half life are commonly determined from drug concentrations after single bolus administration. The advantage of this procedure is that pharmacokinetic data can be easily derived from the resultant blood levels. But some disadvantages are associated with this procedure; Firstly, blood levels due to a bolus injection often decay very rapidly. As a consequence, the overall sampling time is limited by the precision of the chemical estimation method, and this may lead to estimation errors in the terminal half-life. Secondly, a single bolus is frequently not the usual way the drug is used to achieve the desired pharmacodynamic effect. This, in turn, often leads to small series for the determination of mean kinetic data. The problem of estimating the pharmacokinetic data from drug concentration and the known administration scheme is commonly referred to as the deconvolution problem. In recent years several methods for special administration schemes have been pub-lished (1–5) but little has been worked out for arbitrary administration schemes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Colbrun WA, Shen D, Gilbaldi M (1976) Pharmacokinetic analysis of drug concentration data obtained during repetitive drug administration. J Pharm Biopharm 4; 469.
Colbrun WA, Gilbaldi M (1977) Pharmacokinetic analysis of drug concentration data obtained during repetitive drug administration. J Pharm Sci 66; 530.
Cutler JD (1978) Numerical Deconvolution by least squares: use of prescribed input functions. J Pharmacokin Biopharm 6; 227.
Cutler JD (1978) Numerical Deconvolution by least squares: use of polynomials to represent the input function. J Pharmacokin Biopharm 6; 243.
von Hattingberg HM, Brockmeier D (1980) Drug concentration control and pharmacokinetic analysis during long term therapy with desk top computers. In: Pharmacokinetics. A 25 year old discipline. Eds: E Gladtke, G Hermann, Gustav Fischer, Stuttgart New York.
Schwilden H (1981) A general method for calculating the dosage scheme in linear pharmacokinetics. Eur J Clin Pharmacol 20; 387.
Schüttler J (1981) Klinische Pharmakokinetik von Fentanyl unter besonderer Berücksichtigung eines respiratorischen Rebound — Phänomens Thesis, University of Bonn.
Krüger-Thiemer E (1968) Continuous intravenous infusion and multicompartment accumulation. Eur J Clin Pharmacol 4; 317.
Lauven PM, Stoeckel H, Schwilden H (1982) Ein pharmacokinetisch begründetes Infusionsmodell für Midazolam. Eine mikroprozessor gesteuerte Applikationsform zur Erreichung konstanter Plasmaspiegel. Anästhesist — in press.
Schwilden H, Stoeckel H, Schüttler H, Lauven PM (1981) Pharmacokmetik haloge-nierter Anästhetika. Proceed Zentraleurop Anästhesiekongress, Berlin, Sept. 1981.
Mapleson WW (1981) Volatile and gaseous anaesthetics. Abstracts of the Association of Anaesthetists of Great Britain and Ireland. Anglo-American Meeting, Sept. 1980, London.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Schwilden, H., Stoeckel, H., Schüttler, J., Lauven, P.M. (1982). Pharmacokinetic Data of Fentanyl, Midazolam and Enflurane as Obtained by a New Method for Arbitary Schemes of Administration. In: Prys-Roberts, C., Vickers, M.D. (eds) Cardiovascular Measurement in Anaesthesiology. European Academy of Anaesthesiology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68690-0_3
Download citation
DOI: https://doi.org/10.1007/978-3-642-68690-0_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11719-3
Online ISBN: 978-3-642-68690-0
eBook Packages: Springer Book Archive