Abstract
The pharmacokinetic characteristics of alfentanil were compared with those of fentanyl in seven healthy volunteers. Each subject was given 170 μg of each drug simultaneously as a 2.5 min i.v. infusion. Venous blood samples were taken over the period 0–360 min and the plasma separated and stored at —20°C until assay. Each sample was assayed in triplicate for fentanyl and alfentanil content, by independent radio-immunoassays. The molar ratio of cross-reactivity of each drug in assay for the other was less than 10−4 in both cases.
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References
Bower S (1981) Plasma protein binding of fentanyl. J Pharm Pharmacol 33; 507.
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© 1982 Springer-Verlag Berlin Heidelberg
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Hull, C.J., Bower, S. (1982). Comparative Pharmacokinetics of Fentanyl and Alfentanil. In: Prys-Roberts, C., Vickers, M.D. (eds) Cardiovascular Measurement in Anaesthesiology. European Academy of Anaesthesiology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68690-0_2
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DOI: https://doi.org/10.1007/978-3-642-68690-0_2
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