Abstract
Two previous studies on the effect of i.v. diazepam on the lower oesophageal sphincter pressure showed that, with a dose of 2.5–10 mg, a decrease occurred(1), but that with a dose of 20 mg, sphincter pressure increased(2). In view of these conflicting data and the fact that diazepam is generally administered orally for premedication, a randomized double-blind study has been performed on nine healthy volunteers receiving either diazepam 10 mg orally or placebo. Measurements were made of gastric pressure, sphincter pressure and barrier pressure (sphincter — gastric pressure) from 45 to 75 min after ingestion of the capsules.
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References
Hall AW, Moussa AR, Clark J, Cooley GR and Skinner DB (1975) The effects of premedication drugs on the lower oesophageal high pressure zone and reflux status of Rhesus monkey and man. Gut 16; 347.
Weiruch TR, Forster CF, Kohler H, Ewe K and Kriebelstein J (1979) Effect of intravenous diazepam on human lower oesophageal sphincter pressure under controlled double blind crossover conditions. Gut 20; 64.
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© 1982 Springer-Verlag Berlin Heidelberg
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Smith, G., Cotton, B.R., Fell, D. (1982). Diazepam Reduces Lower Oesophageal Sphincter Pressure. In: Prys-Roberts, C., Vickers, M.D. (eds) Cardiovascular Measurement in Anaesthesiology. European Academy of Anaesthesiology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68690-0_12
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DOI: https://doi.org/10.1007/978-3-642-68690-0_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11719-3
Online ISBN: 978-3-642-68690-0
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