Abstract
A powerful analgesic which had small effects on respiration would be invaluable to medical practice. In practice it is difficult to measure the respiratory depressing qualities of a drug in a way that relates to clinical practice. Carbon dioxide response curves are rarely undertaken in patients experiencing pain. The range of doses required to achieve comparable levels of analgesia is wide, commonly six or sevenfold(1,2).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Chakravarty K, Tucker W, Rosen M, Vickers MD (1979) Comparison of buprenor-phine and pethidine given intravenously on demand to relieve postoperative pain. Brit Med J 2; 895.
Slattery PJ, Harmer M, Rosen M, Vickers MD (1981) Intravenous meptazinol for postoperative analgesia. Brit J Anaesth 53; 927.
Hovell BS, Ward AE (1977) Pain relief in the postoperative period: a comparative trial of morphine and a new analgesic buprenorphine. J Int Med Res 5; 417.
Cowan A, Doxey JC, Harry EJR (1977) The animal pharmacology of buprenorphine, an oripavine analgesic agent. Brit J Pharmacol 60; 547.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Slattery, P.J., Harmer, M., Rosen, M., Vickers, M.D. (1982). Respiratory Depression with Buprenorphine: Onset Time and Reversal. In: Prys-Roberts, C., Vickers, M.D. (eds) Cardiovascular Measurement in Anaesthesiology. European Academy of Anaesthesiology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68690-0_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-68690-0_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-11719-3
Online ISBN: 978-3-642-68690-0
eBook Packages: Springer Book Archive