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Nebenwirkungen der topischen Therapie

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Pharmakologie dermatologischer Externa

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Zusammenfassung

In den vorausgegangenen Kapiteln wurde bereits eine Anzahl von Nebenwirkungen der dermatologischen Lokaltherapie besprochen. Im folgenden sollen die irritierende, sensibilisierende, phototoxische, photoallergische und kanzerogene Wirkung diskutiert werden.

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Literatur

  • Ackermann BA (1978) Histologie diagnosis of inflammatory skin diseases - a method of pattern analysis. Lea & Febiger, Philadelphia

    Google Scholar 

  • Andersen KE, Maibach HI (1980) Allergic reactions to drugs used topically. Clin Toxicol 16: 415–465

    PubMed  CAS  Google Scholar 

  • Aronson SB (1975) The role of ocular irritation in evaluation of dermatotoxicity. In: Maibach H (ed) Animal Models in Dermatology. Churchill Livingstone, Edinburg London New York, S23–35

    Google Scholar 

  • Bandmann HJ, Calnan CD, Cronin E, Fregert S, Hjorth N, Magnusson B, Maibach H, Malten KE, Meneghini CL, Pirilä V, Wilkinson DS (1972) Dermatitis from applied medicaments. Arch Derm 106: 335–337

    PubMed  CAS  Google Scholar 

  • Bell M, Holmes PM, Nisbet RM, Uttley M, van Abbe NJ (1979) Evaluating the potential eye irritancy of shampoos. Int J Cosm Sci 1: 123–131

    CAS  Google Scholar 

  • Bickers DR (1981) The carcinogenicity and mutagenicity of therapeutical coal tar - a perspective. J invest Derm 77: 173–174

    PubMed  CAS  Google Scholar 

  • Björnberg A (1968) Skin reactions to primary irritants in patients with hand eczema. Oscar Isacsons Tryckeri AB, Gothenburg

    Google Scholar 

  • Björnberg A (1975) Skin reactions to primary irritants in men and women. Acta derm-venereol 55: 191–194

    PubMed  Google Scholar 

  • Blank IH (1969) Action of soaps and detergents on the skin. Practitioner 202: 147–151

    PubMed  CAS  Google Scholar 

  • Blohm SG (1957) The connection between skin-irritating and protein-denaturing effects of some surface active agents. Acta derm-venereol 37: 269–275

    PubMed  CAS  Google Scholar 

  • Buehler EV, Griffith JF (1975) Experimental skin sensitization in the guinea pig and man. In: Maibach H (ed) Animal Models in Dermatology. Churchill Livingstone, Edinburgh London New York, S 56–66

    Google Scholar 

  • Coenraads PJ, Bleumink E, Nater JP (1975) Susceptibility to primary irritants. Age dependence and relation to contact allergic reactions. Cont Derm 1: 377–381

    Google Scholar 

  • Czerwinska-Dihm I, Rudzki E (1981) Skin reactions to primary irritants. Cont Derm 7: 315–319

    CAS  Google Scholar 

  • Dahl MV, Trancik RJ (1977) Sodium lauryl sulfate irritant patch tests: Degree of inflammation at various times. Cont Derm 3: 263–266

    Google Scholar 

  • Draize HJ (1959) Appraisal of the safety of chemicals in foods, drugs, and cosmetics. Assoc Food Drug Officials US

    Google Scholar 

  • Ebner H, Lindemayr H (1977) Ulcus cruris und allergisches Kontaktekzem–Untersuchungen über die Häufigkeit lokaltherapeutisch induzierter Kontaktallergien. Wien klin Wschr 89: 184–188

    Google Scholar 

  • Elder RL (1980) Cosmetic ingredients-their safety assessment. Pathotox, Park Forest South Illinois

    Google Scholar 

  • Epstein HJ, Wuepper KD, Maibach HI (1968) Photocontact dermatitis to halogenated salicyl- anilides and related compounds. Arch Derm 97: 236–244

    PubMed  CAS  Google Scholar 

  • Faucher JA, Goddard ED ( 1978 a) Interaction of keratinous substrates with sodium lauryl sulfate: I. Sorption. J Soc cosm Chem 29: 323–337

    Google Scholar 

  • Faucher JA, Goddard ED ( 1978 b) Interaction of keratinous substrates with sodium lauryl sulfate: II.Permeation through stratum corneum. J Soc cosm Chem 29: 339–352

    Google Scholar 

  • Finkelstein P, Laden K, Miechowski W (1963) New methods for evaluating cosmetic irritancy. J invest Derm 40:11 –14

    Google Scholar 

  • Fisher AA (1977) Contact urticaria due to polyethylene glycol. Cutis 19: 409–412

    PubMed  CAS  Google Scholar 

  • Forbes PD, Davies RE, Urbach F (1976) Phototoxicity and photocarcinogenesis: comparative effects of anthracene and 8-methoxypsoralen in the skin of mice. Food Cosm Toxicol 14: 303–306

    CAS  Google Scholar 

  • Fräki JE, Peltonen L, Hopsu-Havu VK (1979) Allergy to various components of topical preparations in stasis dermatitis and leg ulcer. Cont Derm 5: 97–100

    Google Scholar 

  • Freeman RG, Knox JM (1968) The action spectrum of photocontact dermatitis caused by halogenated salicylanilide and related compounds. Arch Derm 97: 130–136

    PubMed  CAS  Google Scholar 

  • Fregert S et al. (1969) Epidemiology of contact dermatitis. Transact St John’s Hosp Derm Soc (London) 55: 17–35

    CAS  Google Scholar 

  • Frosch PJ (1981) Hautverträglichkeitstestungen für neue kosmetische und dermatologische Stoffe mittels Epicutan Testungen (Duhring Kammer Tests). Akt Derm 7: 166–170

    Google Scholar 

  • Frosch PJ, Kligman AM (1976) The chamber-scarification test for irritancy. Cont Derm 2: 314–324

    CAS  Google Scholar 

  • Futami T, Nakamura J, Hayashi S (1973) Primary irritation of surfactant. I. Primary irritation of alkyldimethylbenzylammoniumchloride ( Alkyl DBAC) (cationic surfactant ). J pharm Soc Jap 93: 1445–1451

    Google Scholar 

  • Gershbein LL, McDonald JE (1977) Evaluation of the corneal irritancy of test shampoos and detergents in various animal species. Fd Cosm Toxicol 15: 131–134

    CAS  Google Scholar 

  • Gloor M, Schnyder UW (1977) Vererbung funktioneller Eigenschaften der Haut. Hautarzt 28: 231–234

    PubMed  CAS  Google Scholar 

  • Gloor M, Strack R, Geissler H, Friederich HC (1972) Quantity and composition of skin surface lipids and alkaline resistance in subjects with contact allergy and in healthy controls. Arch Derm Forsch 245: 184–190

    CAS  Google Scholar 

  • Götte E (1966) Synthetische Tenside in medizinisch-kosmetischen Bädern. Ästhet Med 15: 313–319

    Google Scholar 

  • Götz H, Deichmann B, Zabel M (1978) Zur Frage der iatrogenen Karzinomprovokation durch Teeranwendung in der Dermatologie. Z Hautkr 53: 751–755

    PubMed  Google Scholar 

  • Goldemberg RL (1979) Antiirritants. J Soc cosm Chem 30: 415–427

    CAS  Google Scholar 

  • Goodwin BFJ, Crevel RWR, Johnson AW (1981) A comparison of three guinea pig sensitization procedures for the detection of 19 reported human contact sensitizers. Cont Derm 7: 248–258

    CAS  Google Scholar 

  • Greither A, Gisbertz C, Ippen H (1967) Teerbehandlung und Krebs. Z Haut-Geschl Kr 42: 631–635

    CAS  Google Scholar 

  • Guillot JP, Martini MC, Giauffret JY (1977) Safety evaluation of cosmetic raw materials. J Soc cosm Chem 28: 377–393

    CAS  Google Scholar 

  • Guillot JP, Giauffret JY, Martini MC, Gönnet JF, Soule G (1980) Safety evaluation of cosmetic raw materials: results obtained with 160 samples from various origin. IFREB Lancaster CED Bericht, Lyon

    Google Scholar 

  • Hannuksela M (1979) Allergic and toxic reactions caused by cream bases in dermatologic patients. Int J Cosm Sei 1: 257–263

    CAS  Google Scholar 

  • Hannuksela M, Kousa M, Pirilä V (1976) Contact sensitivity to emulsifiers. Cont Derm 2: 201 - 204

    CAS  Google Scholar 

  • Harber LC (1981) Current status of mammalian and human models for predicting drug photo-sensitivity. J invest Derm 77:65– 70

    Google Scholar 

  • Harber LC, Shalita AR (1975) The guinea pig as an effective model for the demonstration of immunologically mediated contact photosensitivity. In: Maibach H (ed) Animal Models in Dermatology. Churchill Livingstone, Edinburg London New York, p 90–102

    Google Scholar 

  • Hardy J (1973) Allergy, hypersensitivity and cosmetics. J Soc cosm Chem 24: 423–468

    CAS  Google Scholar 

  • Hassing JH, Nater JP, Bleumink E (1982) Irritancy of low concentrations of soap and synthetic detergents as measured by skin water loss. Dermatologica 164: 314–321

    PubMed  CAS  Google Scholar 

  • Hilfrich J, Mohr U (1972) Vergleichende Untersuchungen zur carcinogenen Wirkung des herkömmlichen Steinkohlenteers und einer neuen synthetischen Teermischung. Arch Derm Forsch 242: 176–178

    CAS  Google Scholar 

  • Hirohata T, Masuda Y, Horie A, Kuratsune M (1973) Carcinogenicity of tar-containing skin drugs: animal experiment and chemical analysis. Gann 64: 323–330

    PubMed  CAS  Google Scholar 

  • HönigsmannH, Wolff K, Gschnait F, Brenner W, Jaschke E (1980) Keratoses and non melanoma skin tumors in long-term photochemotherapy ( PUVA ). J Amer Acad Derm 3: 406–414

    Google Scholar 

  • Holst R, Möller J (1975) One hundred twin pairs patch tested with primary irritants. Brit J Derm 93: 145–149

    PubMed  CAS  Google Scholar 

  • Horio T (1981) Evaluation of drug phototoxicity by photosensitization of Trichophyton menta-grophytes. Brit J Derm 105: 365–370

    PubMed  CAS  Google Scholar 

  • Ichikawa H, Armstrong RR, Harber LC (1981) Photoallergy contact dermatitis in guinea pigs: improved induction technique using Freund’s adjuvant. J invest Derm 76: 498–501

    PubMed  CAS  Google Scholar 

  • Illig L, Paul E, Eyer P, Weger N, Born W (1979) Die Behandlung der Psoriasis vulgaris mit Schwefel-Lost extern unter besonderer Berücksichtigung ihres möglichen Carcinogeneserisi- kos - 3. Mitteilung: Klinisch experimentelle Untersuchungen über das Ausmaß der percuta- nen und inhalativen Aufnahme von Schwefel-Lost. Z Hautkr 54: 941-951

    Google Scholar 

  • Jacobi O (1949) Methode zur objektiven Prüfung der Reinigungswirkung von Waschmitteln auf der menschlichen Haut. Arch Derm Syph 188: 197–201

    Google Scholar 

  • Jacobi O (1951) Physiologische Reaktion der Haut und ihre Beeinflussung durch Seifen. Hautarzt 2: 109–114

    Google Scholar 

  • Jensen O, Petersen SH, Vesterager L (1980) Contact sensitization to benzoyl peroxide following topical treatment of chronic leg ulcers. Cont Derm 6: 179–182

    CAS  Google Scholar 

  • Jolly M, Swan AG (1980) The effects on rat skin of prolonged exposure to water. Brit J Derm 103: 387–395

    PubMed  CAS  Google Scholar 

  • Jung EG (1966) Experimentelle Untersuchung und klinische Erprobung eines neuen Teer-Öl- Hautbades. Praxis 55: 1077–1082

    PubMed  CAS  Google Scholar 

  • Jung EG, Bohnert E (1979) Lichtbiologie der Haut. In: Handbuch der Haut- und Geschlechtskrankheiten, Ergänzungswerk Bd 1, Teil 4A, Springer, Berlin Heidelberg New York S 459–540

    Google Scholar 

  • Jung EG, Hardmeier T (1967) Zur Histologie der photoallergischen Testreaktion. Dermatolo- gica 135: 243–252

    CAS  Google Scholar 

  • Kästner W (1977) Zur Speziesabhängigkeit der Hautverträglichkeit von Kosmetikgrundstoffen. J Soc cosm Chem 28: 741–754

    Google Scholar 

  • Kästner W, Frosch PJ (1981) Hautirritationen verschiedener anionenaktiver Tenside im Duhring-Kammer-Test am Menschen im Vergleich zu in vitro- und tierexperimentellen Methoden. Fette-Seifen-Anstrichmittel 83: 33–46

    Google Scholar 

  • Kaidbey KH, Allen H (1981) Photocontact allergy to benzocaine. Arch Derm 117: 77–79

    PubMed  CAS  Google Scholar 

  • Kaidbey KH, Kligman AM (1977) Clinical and histological study of coal tar phototoxicity in humans. Arch Derm 113: 592–595

    PubMed  CAS  Google Scholar 

  • Kaidbey KH, Kligman AM (1978) Identification of topical photosentizing agents in humans. J invest Derm 70: 149–151

    PubMed  CAS  Google Scholar 

  • Kaidbey KH, Kligman AM (1980) Photomaximization test for identifying photoallergy contact sensitizers. Cont Derm 6: 161–169

    CAS  Google Scholar 

  • Kaidbey KH, Kligman AM (1981) Photosensitization by coumaren derivates. Arch Derm 117: 258–263

    PubMed  CAS  Google Scholar 

  • Kassis V, Mortensen T, Sondergaard J (1981) Prostaglandin in suction-separated human epidermal tissue in primary irritant dermatitis. Acta derm venereol (Stockh.) 61: 459–461

    Google Scholar 

  • Kero M, Hannuksela M (1980) Guinea pig maximization test, open epicutaneous test and chamber test in induction of delayed contact hypersensivity. Cont Derm 6: 341–344

    CAS  Google Scholar 

  • Klecak G, Geleick H, Frey JR (1977) Screening of flagrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods. J Soc cosm Chem 28: 53–64

    Google Scholar 

  • Kligman AM (1966) The identification of contact allergens by human assay I - III. J invest Derm 47:369–374, 375–392, 393–409

    Google Scholar 

  • Kligman AM, Epstein W (1975) Updating the maximization test for identifying contact allergens. Cont Derm 1: 231–239

    CAS  Google Scholar 

  • Kligman AM, Wooding WM (1967) A method for the measurement and evaluation of irritants on human skin. J invest Derm 49: 78–94

    PubMed  CAS  Google Scholar 

  • Korhevar IE (1981) Phototoxicity mechanisms: chlorpromazine photosentized damage to DNA and cell membranes. J invest Derm 76: 59–64

    Google Scholar 

  • Lassus A, Reunala T, Idänpää-Heikkilä J, Juvakoski T, Salo O (1981) PUVA treatment and skin cancer: a follow-up study. Acta derm-venereol 61: 141–145

    PubMed  CAS  Google Scholar 

  • LeydenJJ, Kligman AM (1979) Contact dermatitis to neomycin sulfate. J Amer med Ass 242: 1276–1278

    Google Scholar 

  • Ludwig E (1976) Möglichkeiten und Grenzen der Prüfung von Kosmetika auf Verträglichkeit am Menschen. J Soc cosm Chem 27: 345–349

    Google Scholar 

  • McMillan FSK, Rafft RR, Elvers WB (1975) A comparison of the skin irritation produced by cosmetic ingredients and formulations in the rabbit, guinea pig, and beagle dog to that observed in the human. In: Maibach H (ed) Animal Models in Dermatology. Churchill Livingstone, Edinburgh London New York, p 12–22

    Google Scholar 

  • Magnusson B, Kligman AM (1969) The identification of contact allergens by animal assay. The guinea pig maximization test. J Invest Derm 52: 268–276

    Google Scholar 

  • Maguire HC (1975) Estimation of the allergenicity of prospective human contact sensitizers in the guinea pig. In: Maibach HI (ed) Animal Models in Dermatology. Churchill Livingstone, Edinburgh London New York, p 67–75

    Google Scholar 

  • Maguire HC (1980) Allergic contact dermatitis in the hamster. J invest Derm 75: 166–169

    PubMed  CAS  Google Scholar 

  • Maibach HI, Johnson HL (1975) Contact urticaria syndrome-contact urticaria to diethyltolu- amide (immediate type hypersensitivity). Arch Derm 111: 726–730

    PubMed  CAS  Google Scholar 

  • Maibach HI, Marzulli FN (1975) Phototoxicity (photoirritation) from topical agents In: Maibach HI (ed) Animal Models in Dermatology. Churchill Livingstone, Edinburgh London New York, p 84–89

    Google Scholar 

  • Malten KE, Thiele FAJ (1973) Some theoretical aspects of “orthergic” (= irritant) dermatitis. Arch Belg Derm 28: 9–22

    Google Scholar 

  • Marzulli FN, Maibach HI (1973) Antimicrobials: Experimental contact sensitization in man. J Soc cosm Chem 24: 399–421

    Google Scholar 

  • Marzulli FN, Maibach HI (1974) The use of graded concentrations in studying skin sensitizers: experimental contact sensitization in man. Fd Cosm Toxicol 12: 219–227

    CAS  Google Scholar 

  • Marzulli FN, Maibach HI (1976) Contact allergy: predictive testing in man. Cont Derm 2: 1–17

    CAS  Google Scholar 

  • Mathias CGT, Maibach HI (1978) Dermatotoxicology monographs. I. Cutaneous irritation: Factors influencing the response to irritants. Clin Toxicol 13: 333–346

    Google Scholar 

  • Maughan WZ, Muller SA, Perry HO, Pittelkow MR, O’Brien PC (1980) Incidence of skin cancers in patients with atopic dermatitis treated with coal tar - a 25 year follow-up study. J Amer Acad Derm 3: 612–615

    CAS  Google Scholar 

  • Maurer Th, Thomann P, Weirich EG, Hess R (1975) The optimization test in the guinea pig. A method for the predictive evaluation of the contact allergenic!ty of chemicals. Agents Actions 5: 174–179

    Google Scholar 

  • Maurer Th, Thomann P, Weirich EG, Hess R (1978) Predictive evaluation in animals of the contact allergenic potential of medically important substances. 1. Comparison of different methods of inducing and measuring cutaneous sensitiziation. Cont Derm 4: 321–333

    Google Scholar 

  • Maurer Th, Thomann P, Weirich EG, Hess R (1979) Predicitve evaluation in animals of the contact allergenic potential of medically important substances. 2. Comparison of different methods of cutaneous sensitization with “weak” allergens. Cont Derm 5: 1–10

    Google Scholar 

  • Maurer Th, Weirich EG, Hess R (1980) The optimization test in the guinea pig in relation to other predictive sensitization methods. Toxicology 15: 163–171

    PubMed  CAS  Google Scholar 

  • McOsker DE, Beck LW (1967) Characteristics of accomodated (hardened) skin. J invest Derm 48: 372–383

    PubMed  CAS  Google Scholar 

  • Mezei M (1970) Dermatitic effect of nonionic surfactants. V. The effect of nonionic surfactants on rabbit skin as evaluated by radioactive tracer techniques in vivo. J invest Derm 54: 510–517

    PubMed  CAS  Google Scholar 

  • Osteroth D, Heers W (1971) Hautschützende Zusätze zu Seifen. Seifen-Fette-Wachse 97: 495–497

    Google Scholar 

  • Pittelkow MR, Perry HO, Muller SA, Maughan WZ, O’Brien PC (1981) Skin cancer in patients with psoriasis treated with coal tar. Arch Derm 117: 465–468

    PubMed  CAS  Google Scholar 

  • Polak L (1980) Current concept of allergic skin reactions. Int J cosm Sci 2: 251–261

    CAS  Google Scholar 

  • Prottey C, Ferguson T (1975) Factors which determine the skin irritation potential of soaps and detergents. J Soc cosm Chem 26: 29–46

    CAS  Google Scholar 

  • Rajka G (1975) Atopic dermatitis. WB Saunders, London Philadelphia Toronto

    Google Scholar 

  • Reitamo S, Tolvanen E, Konttinen YT, Käyhkö K, Förström L, Salo OP (1981) Allergic and toxic contact dermatitis: inflammatory cell subtypes in epicutaneous test reactions. Brit J Derm 105: 521–527

    PubMed  CAS  Google Scholar 

  • Rietschel RL (1978) Photocontact dermatitis to hydrocortisone. Cont Derm 4: 334–337

    CAS  Google Scholar 

  • Röckl H, Müller E, Holtermann W (1966) Zum Aussagewert positiver Epicutantests bei Säuglingen und Kindern. Arch klin exp Derm 226: 407–419

    PubMed  Google Scholar 

  • Roenigk HH (1980) Skin cancer in the PUVA-48 cooperative study of psoriasis. J invest Derm 74: 250

    Google Scholar 

  • Rudner EJ, Clendenning WE, Epstein E, Fischer AA, Jillson OF, Jordan WP, Kanof N, Larsen W, Maibach HI, Mitchell JC, O’Quinn SE, Schorr WF, Sulzberger MB (1975) The frequency of contact sensitivity in North America 1972–74. Cont Derm 1: 277–280

    Google Scholar 

  • RudzkiE, GrzywaZ, BruoWS (1976) Sensitivity to 35 essential oils. Cont Derm 2: 196–200

    Google Scholar 

  • SatoY, KatsumuraY, Ichikawa H, KobayashiT, KozukaT, Morikawa F, Ohta S (1981) A modified technique of guinea pig testing to identify delayed hypersensitivity allergens. Cont Derm 7: 225–237

    Google Scholar 

  • SchaafF (1969) Probleme dermatologischer Grundlagenforschung. AHüthig, Heidelberg Schmähl D ( 1977 ) Iatrogenic carcigonenesis. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Schmähl D (1981) Maligne Tumoren - Entstehung, Wachstum, Chemotherapie. 3. Auflage, Editio Cantor, Aulendorf

    Google Scholar 

  • Schmähl D, Bertram B (1981) Chemische Carcinogene und ihre Bedeutung für die Krebsentstehung beim Menschen unter besonderer Berücksichtigung dermatologischer Aspekte. Dermatosen 29: 75–79

    Google Scholar 

  • Schneider W (1953) Hautschädigungen durch Seifen und Waschmittel. Fette-Seifen 55: 309–312

    Google Scholar 

  • Schulz KH, Rose G (1957) Untersuchungen über die Reizwirkung von Fettsäuren und Alkylsulfaten definierter Kettenlänge auf die menschliche Haut. Arch klin exp Derm 205: 254–260

    PubMed  CAS  Google Scholar 

  • Shelanski HA, Shelanski MV (1953) A new technique of human patch test. Proc Sei Sect Toil Goods Ass 19: 46–49

    Google Scholar 

  • Shellow WVR, Rapaport M J (1981) Comparison testing of soap irritancy using aluminium chamber and standard patch methods. Cont Derm 7: 77–79

    CAS  Google Scholar 

  • Shubik P (1975) Skin carcinogenesis. In: Maibach HI (ed) Animal Models in Dermatology. Churchill Livingstone, Edinburgh London New York, p 147–155

    Google Scholar 

  • Smeenk G (1969) The influence of detergents on the skin (a clinical and biochemical study). Arch klin exp Derm 235: 180–191

    PubMed  CAS  Google Scholar 

  • Steinberg M, Akers WA, Weeks M, McCreesh AH, Maibach HI (1975) A comparison of test techniques based on rabbit and human skin responses to irritants with recommendations regarding the evaluation of mildly or moderately irritating compounds. In: Maibach HI (ed) Animal Models in Dermatology. Churchill Livingstone, Edinburgh London New York, p 1–11

    Google Scholar 

  • Stern RS, Thibodequ LA, Kleinerman RA, Parrish JA, Fitzpatrick TB (1979) Risk of cutaneous carcinoma in patients treated with oral methoxosalen photochemotherapy for psoriasis. New Engl J Med 300: 809

    PubMed  CAS  Google Scholar 

  • Stern RS, Zierler S, Parrish JA (1980) Skin carcinoma in patients with psoriasis treated with topical tar and artificial ultraviolet radiation. Lancet I: 732–735

    Google Scholar 

  • Stern RS, Parrish JA, Bleich HL, Fitzpatrick TB (1981) PUVA (psoralen and ultraviolet A) and squamous cell carcinoma in patients with psoriasis. J invest Derm 76: 311

    Google Scholar 

  • Stillman MA, Maibach HI, Shalita AR (1975) Relative irritancy of free acids of different chain length. Cont Derm 1: 65–69

    CAS  Google Scholar 

  • Stott CW, Stasse J, Bonomo R, Campbell AH (1970) Evaluation of the phototoxic potential of topically applied agents using long-wave ultraviolet light. J invest Derm 55: 335–338

    PubMed  CAS  Google Scholar 

  • Sugai T, Higashi J (1975) Hypersensitivity to hydrogenated lanolin. Cont Derm 1: 146–157

    CAS  Google Scholar 

  • Tronnier H (1965) Zur Standardisierung von Wasch versuchen an der menschlichen Haut. Fette-Seifen-Anstrichmittel 67: 512–514

    Google Scholar 

  • Tronnier H, Schuster G, Modde H (1965) Zusammenhänge zwischen Wascheffekt und Hautverträglichkeit anionenaktiver Tenside. Arch klin exp Derm 221: 232–249

    PubMed  CAS  Google Scholar 

  • Uttley M, van Abbé NJ (1973) Primary irritation of the skin: mouse ear test and human patch test procedures. J Soc cosm Chem 24, 217–227

    Google Scholar 

  • Valér M (1969) Die vergleichende Untersuchung der Reizwirkung von Waschmitteln auf die menschliche Haut. 2. Die Untersuchung von anionenaktiven bzw. nichtionogenen Detergen- zien und alkalischen Waschmitteln. Die Untersuchung des Zusammenhanges zwischen dem pH-Wert und der Reizwirkung. Berufsdermatosen 17: 136–162

    PubMed  Google Scholar 

  • Warshaw TG, Herrmann F (1952) Studies of skin reactions to propylene glycol. J invest Derm 19: 423–429

    PubMed  CAS  Google Scholar 

  • Weigand DA, Gaylor JR (1974) Irritant reaction in negro and caucasian skin. South med J 67: 548–552

    PubMed  CAS  Google Scholar 

  • Weinberg EH, Springer ST (1981) The evaluation in vitro of flagrance materials for phototoxic activity. J Soc cosm Chem 32: 303–315

    CAS  Google Scholar 

  • Wendt H (1977) Untersuchungen zur phototoxischen und photoallergischen Wirkung von Fluocortin-butylester-Creme, -Salbe und-Fettsalbe. Arzneimittel-Forsch 27: 2238 - 2240

    CAS  Google Scholar 

  • Willis I, Kligman AM (1968) The mechanism of photoallergic contact dermatitis. J invest Derm 51: 378–384

    PubMed  CAS  Google Scholar 

  • Wiskemann A, Hoyer H (1971) Zur Phototoxizität von Teerpräparaten. Hautarzt 22: 257–258

    PubMed  CAS  Google Scholar 

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  1. Moltkestraße 18, D-7500, Karlsruhe 1, Germany

    Prof. Dr. med. Max Gloor (Direktor der Hautklinik am Klinikum der Stadt Karlsruhe)

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  1. Prof. Dr. med. Max Gloor
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Gloor, M. (1982). Nebenwirkungen der topischen Therapie. In: Pharmakologie dermatologischer Externa. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68681-8_10

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